ID A0A3Q0GR08_ALLSI Unreviewed; 1044 AA.
AC A0A3Q0GR08;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Signal peptide, CUB and EGF-like domain-containing protein 3 isoform X1 {ECO:0000313|RefSeq:XP_025061832.1};
GN Name=SCUBE3 {ECO:0000313|RefSeq:XP_025061832.1};
OS Alligator sinensis (Chinese alligator).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Crocodylia; Alligatoridae; Alligatorinae;
OC Alligator.
OX NCBI_TaxID=38654 {ECO:0000313|Proteomes:UP000189705, ECO:0000313|RefSeq:XP_025061832.1};
RN [1] {ECO:0000313|RefSeq:XP_025061832.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR RefSeq; XP_025061832.1; XM_025206047.1.
DR AlphaFoldDB; A0A3Q0GR08; -.
DR STRING; 38654.A0A3Q0GR08; -.
DR KEGG; asn:102369913; -.
DR InParanoid; A0A3Q0GR08; -.
DR OrthoDB; 5477406at2759; -.
DR Proteomes; UP000189705; Unplaced.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR CDD; cd00041; CUB; 1.
DR CDD; cd00054; EGF_CA; 3.
DR Gene3D; 2.10.25.10; Laminin; 9.
DR Gene3D; 2.60.120.290; Spermadhesin, CUB domain; 1.
DR Gene3D; 2.10.50.10; Tumor Necrosis Factor Receptor, subunit A, domain 2; 3.
DR InterPro; IPR026823; cEGF.
DR InterPro; IPR000859; CUB_dom.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR024731; EGF_dom.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR035914; Sperma_CUB_dom_sf.
DR InterPro; IPR011641; Tyr-kin_ephrin_A/B_rcpt-like.
DR PANTHER; PTHR24046; SIGNAL PEPTIDE, CUB AND EGF-LIKE DOMAIN-CONTAINING; 1.
DR PANTHER; PTHR24046:SF2; SIGNAL PEPTIDE, CUB AND EGF-LIKE DOMAIN-CONTAINING PROTEIN 3; 1.
DR Pfam; PF12662; cEGF; 1.
DR Pfam; PF00431; CUB; 1.
DR Pfam; PF12947; EGF_3; 1.
DR Pfam; PF07645; EGF_CA; 2.
DR Pfam; PF07699; Ephrin_rec_like; 3.
DR Pfam; PF14670; FXa_inhibition; 4.
DR PRINTS; PR00907; THRMBOMODULN.
DR SMART; SM00042; CUB; 1.
DR SMART; SM00181; EGF; 10.
DR SMART; SM00179; EGF_CA; 7.
DR SMART; SM01411; Ephrin_rec_like; 4.
DR SUPFAM; SSF57196; EGF/Laminin; 3.
DR SUPFAM; SSF57184; Growth factor receptor domain; 3.
DR SUPFAM; SSF49854; Spermadhesin, CUB domain; 1.
DR PROSITE; PS00010; ASX_HYDROXYL; 5.
DR PROSITE; PS01180; CUB; 1.
DR PROSITE; PS01186; EGF_2; 4.
DR PROSITE; PS50026; EGF_3; 4.
DR PROSITE; PS01187; EGF_CA; 3.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Reference proteome {ECO:0000313|Proteomes:UP000189705};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 65..105
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 148..184
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 329..369
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 370..408
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 855..967
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DISULFID 374..384
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 1044 AA; 115836 MW; E0365359FED0C88D CRC64;
MCPAISSRWF LVINVLYVRK YSSWALRNQE ASQFLRSAER SGCRAFIPRD SGAFTSRWQQ
LFITDVDECI EGTDNCHIDA ICQNTPRSYK CICKSGFSGD GKHCKDVDEC ERDDNAGCVH
ECVNIPGNYR CTCYDGFRLA QDGHNCLDLD ECSVGNGGCQ QTCINMMGSY ECHCREGFFL
SDNQHTCIQR PEEGMNCMNK NHGCAHICRE TPKGGIACEC RPGFELTKNQ RDCKLTCNYG
NGGCQHTCDD TDQGPKCGCH VKFVLFSDGK TCIGERHLQQ HATSQTFSNE TCAVNNGGCE
NKCQDAATGV QCSCPMGFTL QVDRKTCKDI DECGQNNGGC DHICRNTVGS FECSCRKGYK
LLINERTCQD IDECSFDRTC DHICINTPGS FHCLCHTGYT LYGVTHCGDI DECSINRGGC
KFGCINTPGS YECTCPAGCK LHWNKKDCIA SACRPSELVK CLVGSASHRA TLSCNKNGKK
DSCSLTCTSK ARFLPESDSS YTVSCGTPIQ RQGAQQRPGN SSHHCVETVA APIKQKASFK
IKDAKCHLHP RAKGKQDESG RPGAPGGVAP CLDCQVTFVN LKCDSSRKGK GRRARNPSNK
EVTRITLEFE AEIKPEEITA SCNMNCLRQR VEKKLKSAIK ALKKSINQER FLIRFAGMEY
EVARKLSMAL ERQESCGPGQ QRVGSKCVSC SQGTYYHGQM EQCVPCPPGT YQEKEGQLSC
DHCPRGDAYG PAGATNVTSC AGQCLPGQHS VDGFKPCQPC PRGSYQPEVG RALCFSCGGG
LTTKHEGAFS FQDCDTKVQC SPGHYYNTSV HRCIRCAVGT YQPDFRQNYC IACPGNTTTD
FDGSTSVSQC KNRQCGGELG EYTGYIESPN YPGNYPANIE CTWNINPPPK RKILIVVPEI
FLPSEDECGD VLVMRKNSSP SSITTYETCQ TYERPIAFTA RSRKLWINFK TSEANSAKGF
QIPYVTYDED YEQLVEDIVR DGRLYASENH QEILKDKKLI KAFFDVLAHP QNYFKYTEKH
KEMLPRSFIK LLRSKVTSFL RPYK
//
