ID A0A3Q0GTH2_ALLSI Unreviewed; 1409 AA.
AC A0A3Q0GTH2;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=Zona pellucida sperm-binding protein 1 {ECO:0000313|RefSeq:XP_025062727.1};
GN Name=ZP1 {ECO:0000313|RefSeq:XP_025062727.1};
OS Alligator sinensis (Chinese alligator).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Crocodylia; Alligatoridae; Alligatorinae;
OC Alligator.
OX NCBI_TaxID=38654 {ECO:0000313|Proteomes:UP000189705, ECO:0000313|RefSeq:XP_025062727.1};
RN [1] {ECO:0000313|RefSeq:XP_025062727.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004251};
CC Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004251}.
CC Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane
CC protein {ECO:0000256|ARBA:ARBA00004479}. Zona pellucida
CC {ECO:0000256|ARBA:ARBA00024183}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00779}.
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DR RefSeq; XP_025062727.1; XM_025206942.1.
DR STRING; 38654.A0A3Q0GTH2; -.
DR KEGG; asn:102370478; -.
DR InParanoid; A0A3Q0GTH2; -.
DR OrthoDB; 4608020at2759; -.
DR Proteomes; UP000189705; Unplaced.
DR GO; GO:0035805; C:egg coat; IEA:UniProtKB-SubCell.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0007338; P:single fertilization; IEA:UniProtKB-KW.
DR CDD; cd00111; Trefoil; 2.
DR Gene3D; 2.60.40.4100; Zona pellucida, ZP-C domain; 2.
DR Gene3D; 2.60.40.3210; Zona pellucida, ZP-N domain; 2.
DR InterPro; IPR000519; P_trefoil_dom.
DR InterPro; IPR044913; P_trefoil_dom_sf.
DR InterPro; IPR042235; ZP-C.
DR InterPro; IPR001507; ZP_dom.
DR InterPro; IPR017977; ZP_dom_CS.
DR PANTHER; PTHR23343; ZONA PELLUCIDA SPERM-BINDING PROTEIN; 1.
DR PANTHER; PTHR23343:SF41; ZONA PELLUCIDA SPERM-BINDING PROTEIN 1; 1.
DR Pfam; PF00100; Zona_pellucida; 2.
DR SMART; SM00018; PD; 2.
DR SMART; SM00241; ZP; 2.
DR SUPFAM; SSF57492; Trefoil; 2.
DR PROSITE; PS51448; P_TREFOIL_2; 2.
DR PROSITE; PS00682; ZP_1; 2.
DR PROSITE; PS51034; ZP_2; 2.
PE 4: Predicted;
KW Cleavage on pair of basic residues {ECO:0000256|ARBA:ARBA00022685};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Extracellular matrix {ECO:0000256|ARBA:ARBA00022530};
KW Fertilization {ECO:0000256|ARBA:ARBA00023279};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000189705};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}; Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..21
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 22..1409
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5018271812"
FT TRANSMEM 550..570
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 591..616
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 177..217
FT /note="P-type"
FT /evidence="ECO:0000259|PROSITE:PS51448"
FT DOMAIN 222..498
FT /note="ZP"
FT /evidence="ECO:0000259|PROSITE:PS51034"
FT DOMAIN 1053..1093
FT /note="P-type"
FT /evidence="ECO:0000259|PROSITE:PS51448"
FT DOMAIN 1098..1374
FT /note="ZP"
FT /evidence="ECO:0000259|PROSITE:PS51034"
FT REGION 133..158
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 765..904
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 933..988
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1379..1409
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 765..805
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 813..844
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 858..876
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 886..904
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 945..982
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1409 AA; 156669 MW; D5C2FF4A3E5955F3 CRC64;
MRLGYRCLVA LVLFFLRTAR SQDAFLRISF SVLQHRYDCG DYGMQLVVYP SQGYTIHFKV
MDEFGTSFEV TNCSICLHWI TTGWDGAVVF STGYDGCHVL KKDGRNYLRV HVEELQSTGE
IATTLNVNMI CPKPTEHDSS SEENVHSLPR PSLQHPAPPP GLVRLVPSNI GSHLTWQQCQ
VPAGKIPCAD TPGRTACLQA GCCYNEMDRV TPCYYGNTAT VQCLMDGHFI LVVSREMSEY
PIKLDTVRLA YAQAECNPIH VTEAFVMFRF PFTQCGTTVQ LTRSKLIYEN QLISSIDVKN
GPYGGITRDS IFILHARCIF NTSNFLPVQA EVSLPPSLPP VSEAGPLLLE LRIATDETYS
TYYVDGEYPV VKVLKDPVYV EVRTLERTDP SLVLVLEKCW ATPSANPLEQ PQWPILVNGC
PFMGDNYRTQ LVPTGSASSE LPFPTHYQRF VISTFAFVDT ASTVALGGPV YLFCSASACH
PSQLEPCRPI CSNPQLDRVR RYLNTNNGTE KPLDLVSSHG PVIFQGIHEP RRERVYENED
VVSRTHPSPV FLGALALLVV TLLIALLLLY RRRGGMMTRT QSWLQNQASV FYCPAISAMW
LGCRCFIALV LIISLGRTHG QLDFHRVTHS FLQYKYDCGD YTMQLLVFPS WGHTIQFKVL
DEFGTPFEVS NCSICRHWIS SGEGGAVIFS AGYDGCRVLK KDGRHHLRVR VEELLSTGII
MASYDVNMTC PKLIEYDSTL EDNLRSVSPP SLVHLVPQPQ PGLMRPMPQP QPGLAYPVPQ
PQPGLLRPVP QPQPLPQPLP GLVHSVPQPH PGVVRPVLQP QPHPGVVRPA LQPQPQPQPQ
PLPGLVHPVL QYQPGLVRPV PRPQPQPLPG LVHPIPQSLP QPGLVHPVHH PRPQPLPGLV
YPVPQPQPQP GLVYSAYQPQ PGLVHLNSQL QPQPGLVYPA PQTQPGLMHP VPQPQPQPQP
GLAHPIPQNQ PQPQPPSRIR PIVQPQPGLD QPIPGLLRPV PRPQPLPGLV HPIPQPQHGF
VHPMLQPQPH PSLVRPVPLF YTSTQAGAQL TWEQCRVAAG KIPCGTTPGR AACLQAGCCY
DEMDRMTPCY YGNTATVQCL MDGQFILVIS RHMSEYPINL DSVRIAYAQA GCDPIRMTEA
FVMFQFPFTQ CGTTVQVIGD KLVYENQLIS SIEVRTGPRG SITRDSTYIL HARCIYNASD
FLPLQVEVLM PPTQASVAQF GPLRLQLRIA TDETYSGYYV DREYPVVKVL RDPIYVEVRI
LQRTDPSLVL ALHQCWATPT TNPMEHPQWP ILVDGCPFSG DNYRTQLVPM GSATAELPFP
NHYQRFIIST FTFVDTASYA ALKGEVYIFC SASICHLSQP EPCRPTCQSG ATARARRSLR
TNKEKEKHPN LVNSHGRVIL RGSPGTSRE
//
