ID A0A3Q0GTM6_ALLSI Unreviewed; 2758 AA.
AC A0A3Q0GTM6;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE SubName: Full=Neurobeachin-like protein 2 isoform X8 {ECO:0000313|RefSeq:XP_025063136.1};
GN Name=NBEAL2 {ECO:0000313|RefSeq:XP_025063136.1};
OS Alligator sinensis (Chinese alligator).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Crocodylia; Alligatoridae; Alligatorinae;
OC Alligator.
OX NCBI_TaxID=38654 {ECO:0000313|Proteomes:UP000189705, ECO:0000313|RefSeq:XP_025063136.1};
RN [1] {ECO:0000313|RefSeq:XP_025063136.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_025063136.1; XM_025207351.1.
DR Proteomes; UP000189705; Unplaced.
DR CDD; cd06071; Beach; 1.
DR CDD; cd01201; PH_BEACH; 1.
DR Gene3D; 1.10.1540.10; BEACH domain; 1.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR000409; BEACH_dom.
DR InterPro; IPR036372; BEACH_dom_sf.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR046851; NBCH_WD40.
DR InterPro; IPR031570; NBEA/BDCP_DUF4704.
DR InterPro; IPR046852; Neurobeachin_a-sol.
DR InterPro; IPR023362; PH-BEACH_dom.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR13743; BEIGE/BEACH-RELATED; 1.
DR PANTHER; PTHR13743:SF111; NEUROBEACHIN-LIKE PROTEIN 2; 1.
DR Pfam; PF02138; Beach; 1.
DR Pfam; PF15787; DUF4704; 1.
DR Pfam; PF16057; DUF4800; 1.
DR Pfam; PF20426; NBCH_WD40; 1.
DR Pfam; PF20425; Neurobeachin; 1.
DR Pfam; PF14844; PH_BEACH; 1.
DR SMART; SM01026; Beach; 1.
DR SMART; SM00320; WD40; 3.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF81837; BEACH domain; 1.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS50197; BEACH; 1.
DR PROSITE; PS51783; PH_BEACH; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 2.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000189705};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW ProRule:PRU00221}.
FT DOMAIN 1943..2043
FT /note="BEACH-type PH"
FT /evidence="ECO:0000259|PROSITE:PS51783"
FT DOMAIN 2056..2348
FT /note="BEACH"
FT /evidence="ECO:0000259|PROSITE:PS50197"
FT REPEAT 2501..2534
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 2552..2593
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REGION 1428..1493
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1428..1447
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1460..1493
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2758 AA; 309546 MW; 47A70EBF64D6107C CRC64;
MNFEKIITVQ SLEPRRPEDS VSEIPLLPRD VLHVLSQQLT HCVAQISCEE AAEAGLSQAL
LLIKFFIIIC RNLENVQTDK TPGFIHEVLR LLVACTDKLK STQEQCVSRS QLEHVTTYAL
HLYECLFDPY QTWRRQLSGE IISMQEKSKY KFPPPALPLE FGAFFQGSFQ DSGQLPEALQ
LRLIHLFGAV LSGAKQNALL VITPAAVETL MLVLLRWCSP GDSAPQDPRL LQLTLKSLVG
MIHVLHASSP GQRKVEIRAI LDSYFKVLNS DQPMAALEGA AAACWEDRLI TLRVNMLDAI
PEMLNCGDRP VLQAIFLSNN CFEHIIRLIQ NSKLYVSNKR EAEELGSDLA MRLLTEIDVR
KVFSSSSDAI AVHAIGVLSS IMSNSPSAKE VFKERIGYSH LYEVLKSQSQ PTRTLLQELL
NMAVEGDHSS FPIRLIRNEQ PLLILIAWLP DLMSRDLQVF LSDWLKRICS ASPQSRLTCV
KAGMVSCLLD VLGAEQALDR KCSENLIDLL QVLGSLSIRP GELRQLIKLL WTESGSGAHP
YATQVIRALS GMARKDRPER ALQYFDLTPS MAGIMVPPIQ KWPGSGFAFH AWVCLNEEPR
DNMEQGARLK RKQLYSFFTA SGTGFEAFFT TEGMLVVAVC TKKEYMTVTL PEFPFNDSAW
HCIDIAHIMG RRPFGQNLVN IYTDGQLRKV AQLRFPSLNE SFTSCCIGSA GHRTTTTSTL
CSLPSHSPDL TFSTHPSLCR SQSFPASLGT HAWTPGAIQP LREGLVSTTA AGSQDMEWGT
PTSLEGHLGL VSIFYEALQP AQVKVLFSAG PNVTSPFKPE SDFLELNSKL LLFYTPQACN
NNICLDLSPN HFFDGRLTGH KVVNWDVKDV VNCIGGMGVL LPLLEQVAAK KKETEENQET
HDLVGPELTS SRNAQGMLIP LGKSSEGRLE RNSVAAFLLL VKNFIRRHPV NQESLVQCHG
PAIIGALLQK VSSLMMDMNV LMASQVLMEQ VASESNGLLL HLLYQYLLFD FRIWRNSDFA
VRLGHIQYLS SILKDHKQRI RKKYGVQYIL DSIRMHYGAR REKPITADDV KTVQTSLFSL
VKDFLSRNFS ADEMQSALNY LAGVHDEHQV SGALEVIHGL LKGAPSQDQL YAFLFETGNV
EVFFSLLVQK KFSDEVRERV FKILYKMLKY EKVHERSRHR LKLKDIGYEG LIANLNDVPV
SMLLFRCLLE QVLGSDSPNY KDLVAVVYLS HRAELTVRLD ICRKLFHLIY SQQDMVRQLA
KLVGWQDTLT KLYVKESYES RQHSLSSSGG GGCLDLLKFS EPPGKDLGPE AGKELLDSIG
PASTDLQDLD VFLPLGFEAS DQELSEGFSD HSISPAGRTK SFHSYNFKSF DSLDRTSHSS
SSNTIDIPGQ GDGPHIDALP FDGIYHPLSP FSMSPFDLGL ELGSTSSVTT VESGNQTPGS
QPGTPSPLEN FKPFPGMRAR KSSSLSNVLD ESSYQETLPS DDISNTSNPQ QTPEEELCNL
LTNIIFSVTW RGVEGWDDTA WKERGQVFSV LTKLGTACEL VRPPDEIKRS LLEMMLESAF
TDLKELAPAA LPSLTQNALK LLRLLQDFLF SEGHNNQALW SEKIYEGMNS LLDKLGVWYH
LANGTSDLKE MAQIGLRVLI GYIMLEDTQL HSLAYVKLHS LLQTASAPKK EEACYLLGKL
EMPLRLSLLS KAETFSWLVS IIRTLMDQCY DTLQLQHFLP SLPPTNGSPT FYEDFQLFCT
TPEWRVFIEK HVQPTMAQFE MDTFAKSHDH MSNFWNSCYD ALMSSSLRRE QEKAESRKKF
QELVLEPVLK RSKYENIRHA NVLKQITNHH STVLKQWKSL RRLLTSQRSA WATRDLPQMH
WKLSSAETYS RMRLKLVPNY NFDCHQEASA LRDNLGADHL QTSAESLPLA VAKEAKVSEL
EDDQLAEEDL AILDNHAEPK EQSQREKLVI SEDCELITTV AVIQGRLEVT TQHIYFYDGS
SEKEETEEGI GYDFKRPLSH LREVHLRRYN LRRSALEFFF IDQGNYFVNF KKKVRNKVYS
SILGLHPPNQ IYFGSRSPQE LLKASGLTQK WVYREISNFE YLMQLNTIAG RTYNDLSQYP
VFPWILQDYI SEMLDLNNPA VFRDLSKPIG VANEKHAKDV KEKYESFEDP TGMIDKFHYG
THYSNAAGVM HYMIRTEPFT TLHIQLQSGR FDCSDRQFHS VPAAWQARME NPVDVKELIP
EFFYFSEFLE NQNGFDLGSL QLSNDKVTDV VLPKWACSRE DFISKHRKAL ESEYVSAHLH
EWIDLIFGYK QRGPAAVEAL NVFYYCTYEG AVDLDAIADE TQRKALEGII SNFGQTPCQL
LKEPHPARLS AENAARRLAR LDTYSPNVFE NLGQLKSFFA EGISDGIPLV QAVVPKNQAH
SFITQGSPDV LVTVSANGLL GTHGWLPYDK NISNYFSFTK DPTVSNTKTQ RFLCGPFAPG
VDLSSKTLSI SHDGKLLFSG GHWDNSLQVT SLSKGKVIGH ITRHIDVVTC LALDLCGIYL
ISGSRDTTCM VWQVLQQGGF SCGLASKPVQ VLYGHDNEVT CVAISTELDM AVSGSKDSTI
IIHTIRRGLF MRSIKPPCES SLPATISNLT VGLEGQIVIQ TTVEGRSSLK DQFALHLYSV
NGKHLASVSL DEEITSMCVT EEFVVLGTMQ CSLQIRDLQN LQAAMPPMPM KVPVHSVSVT
KEKSHILVGL EDGKLIVVGA GQPSEVRTGQ FHRRLWRSTR RISQVSSGET EYNPPESK
//
