ID A0A3Q0GUK4_ALLSI Unreviewed; 4669 AA.
AC A0A3Q0GUK4;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=Protocadherin Fat 1 isoform X1 {ECO:0000313|RefSeq:XP_025063449.1};
GN Name=FAT1 {ECO:0000313|RefSeq:XP_025063449.1};
OS Alligator sinensis (Chinese alligator).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Crocodylia; Alligatoridae; Alligatorinae;
OC Alligator.
OX NCBI_TaxID=38654 {ECO:0000313|Proteomes:UP000189705, ECO:0000313|RefSeq:XP_025063449.1};
RN [1] {ECO:0000313|RefSeq:XP_025063449.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR RefSeq; XP_025063449.1; XM_025207664.1.
DR STRING; 38654.A0A3Q0GUK4; -.
DR InParanoid; A0A3Q0GUK4; -.
DR OrthoDB; 2961370at2759; -.
DR Proteomes; UP000189705; Unplaced.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0007156; P:homophilic cell adhesion via plasma membrane adhesion molecules; IEA:InterPro.
DR CDD; cd11304; Cadherin_repeat; 33.
DR CDD; cd00054; EGF_CA; 4.
DR CDD; cd00110; LamG; 1.
DR Gene3D; 2.60.120.200; -; 1.
DR Gene3D; 2.60.40.60; Cadherins; 34.
DR Gene3D; 2.10.25.10; Laminin; 4.
DR InterPro; IPR039808; Cadherin.
DR InterPro; IPR002126; Cadherin-like_dom.
DR InterPro; IPR015919; Cadherin-like_sf.
DR InterPro; IPR020894; Cadherin_CS.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR001791; Laminin_G.
DR PANTHER; PTHR24027; CADHERIN-23; 1.
DR PANTHER; PTHR24027:SF448; FAT ATYPICAL CADHERIN 2; 1.
DR Pfam; PF00028; Cadherin; 29.
DR Pfam; PF00008; EGF; 1.
DR Pfam; PF07645; EGF_CA; 1.
DR Pfam; PF02210; Laminin_G_2; 1.
DR PRINTS; PR00205; CADHERIN.
DR SMART; SM00112; CA; 34.
DR SMART; SM00181; EGF; 5.
DR SMART; SM00179; EGF_CA; 4.
DR SMART; SM00282; LamG; 1.
DR SUPFAM; SSF49313; Cadherin-like; 34.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR SUPFAM; SSF57196; EGF/Laminin; 4.
DR PROSITE; PS00010; ASX_HYDROXYL; 1.
DR PROSITE; PS00232; CADHERIN_1; 12.
DR PROSITE; PS50268; CADHERIN_2; 33.
DR PROSITE; PS00022; EGF_1; 4.
DR PROSITE; PS01186; EGF_2; 2.
DR PROSITE; PS50026; EGF_3; 5.
DR PROSITE; PS01187; EGF_CA; 1.
DR PROSITE; PS50025; LAM_G_DOMAIN; 1.
PE 4: Predicted;
KW Calcium {ECO:0000256|ARBA:ARBA00022837, ECO:0000256|PROSITE-
KW ProRule:PRU00043}; Cell adhesion {ECO:0000256|ARBA:ARBA00022889};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000189705};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 20..43
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 4211..4231
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 64..178
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 179..286
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 397..492
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 493..598
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 606..700
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 747..851
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 852..956
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 957..1063
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1072..1168
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1169..1274
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1275..1386
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1388..1485
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1486..1591
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1592..1696
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1697..1794
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1795..1908
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1909..2008
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2009..2110
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2111..2211
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2212..2312
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2313..2419
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2420..2521
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2522..2625
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2626..2732
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2733..2838
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2839..2947
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2948..3052
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 3053..3154
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 3155..3259
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 3260..3364
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 3365..3469
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 3470..3574
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 3590..3683
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 3819..3856
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 3858..4038
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DOMAIN 4042..4079
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 4081..4117
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 4118..4154
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 4156..4192
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT REGION 4332..4356
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4512..4558
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4645..4669
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4513..4533
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4645..4661
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 3828..3845
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 4069..4078
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 4107..4116
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 4144..4153
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 4182..4191
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 4669 AA; 516421 MW; 1C69639AC2BA9734 CRC64;
MPESVRGSSA LGKRSGKSSW SGYLITAIME RYLTMLLLLL LLVQHFGNCE GNQRPHHASP
MQFTKVQYNA TVYENSAAKT YVGHPVKMGI YIRNPLWDIR YKIISGDNEN LFKAEEYVLG
NFCFLRIRTK GGNTAILNRE VKDHYILTVK AVEKHTNTEA RTKVRVQVLD TNDLRPLFSP
TSYSVSLPEN TAIRTSIARV SATDADIGTN GEFYYSFKER TDMFAIHPTS GVVVLTGRLD
YSEAKLYEME ILAVDRGMKL YGSSGISSMA RLTVHIEQAN EHAPVITAVA LASSESDKDP
TYAVVTVEDS DQGSNGEIAS LSIVAGDPLQ QFKTLRSVPG GKEYKIKAVG HIDWESQPFG
YNLTLQAKDK GYPPRFSSVK VIHVTSPQFK SGPVRFEKDV YRAEISEFAP PNTPVIMVKA
LPSYPHSKYT FKNTPGKIRF NINPHTGLIT ILEKIKAQHA SHLEVEVMTS DRKASAKVLI
KVVSMNSNPP EFMQTSYKAS FDENVPVGTS VMRVSAKDPD EGENGYVTYS IANLNPLPFV
INHFSGIIST SEDLDYELMP RVYNLRIRAS DWGTPYRREV EVPVTITLNN LNDNIPLFEK
INCEGTIPRD LGVGEQITTV SAIDADELQL VRYQIESGNQ LDLFSLNPNS GVLSLKQPLI
DGLGAKVSFH SLRITATDGE NFARPLYINI TIAASRKPVD LQCEETGVAK MLAEKLLQAN
KLHSRGEIED AFFDTHSVNM HPPQFRRTLP TSVEIREDEP VGSSIILVNA TDLDTGFNGK
LVYAISGGND DSHFIVDMET GMLKILSPLD REVRDAYTLN ITVYDLGIPQ KSAWRLLDVK
ILDANDNRPE FLQNSYFVEV SESKELNSDI IQIEAIDRDL GPNGEVKYFL LTDTDIFTID
SVTGVVKVVG ALDREIQHVH FLKIEARDQP NEEPQLFSTV LLKLSLEDIN DNPPQFIPSN
YHVKIREDLP EGTIITWLEA YDPDLGQSSQ VRYSLLDNGD GTFDVDKLSG AIRIVQRLDF
ERKQVYNLTV RAKDKGKPVS LSSTSYVEVE VVDVNENLHP PQFSIFADKG LVKEDAPIGS
SVMTISAYDE DGGRDGEIKY SIRDGSGVGV FRIDEEKGII ETADRLDRET TSHYWLTVYA
TDQGIVPLSS FIEIYIEVGD VNDNAPQTTE PVYHPEVMEN SPKDVSVIQI EAYDPDSSSN
EKLTYKITSG NPQGFFSINP RTGLIATTSR RLDREQQEEH ILEVTVTDNG IPAKSTIARV
IIKVLDENDS KPQFLQKFYK IRLPERDKPE RERTAKREPI YRVIAADKDE GPNAEISYSI
EDGDEQGKFF IEPKTGVVSS KKFSAAGEYD ILSIKAVDNG RPQKSSTTRL HIEWISKPIP
PTEPIFFEEM FFSFTVMESD PVAHMIGVIA VEPLGAPLWF DITGGNYDSR FDVDKGTGTI
IVARPLDAEQ KSNYNLTVEA TDGTRSISTQ VYIKVIDTNN HRPQFSTSKY EVVISEDTVP
ETEILQVTAT DRDEKNKLIY TMQSSTDPIS LKKFRLDPGT GSLYTSEKLD HEAMHQHILI
VMVRDQDVPV KRNYARIVIN VSDTNDHTPW FTSSSYEGRV YESAAVGSAV LQVTALDKDK
GKNAEIVYSI ESGNIGNYFI IDPILGTVKI AKELDRSSRE EYNLMVKATD KGNPPLSEVT
SVHIFVTVSD NAAPKFTSKE YSTEISEGTG IGSFVGMVTA YSQSSVVYEI KDGNIGDAFD
INPNSGVVTS QKILDFETLP VYTLTVQGTN MAGLSTNNTV LVHLQDENDN VPVFTQAEYI
GLVSESASIN SVVLTDKNIP LVIRATDADK DSNALLVYQI VEPSVHKYFA IDSSTGAIRT
VTSLDYEETN IFHFSVQVHD MGAPRLFAEY AANVTIYVID INDCPPVFSK DLYETSILVP
TYKGVQVITV NATDADSGAF SQLIYSITEG NIGEKFSIDS KTGVITIQNT TQLRSRYELA
VRASDGRFAS TASVKINVKE TKASPLKFTQ SSYSAVVQEN STEAKTIAVV TAIGNQMNEP
LFYHILNPDS RFKISYTSGV LSTTGIPFDR EQQESFDVVV EVTGEHKPSV VAHVVVKVTV
EDINDNAPIF VNLPYYAVVK VDSEVGHIVR RVTAVDKDMG KNGEVHYYLK EHHEHFQIGP
TGEISLKKPF ELDTLNKEYL VTVMAKDGGD PAFSAEVIVP ITVMNKAMPV FEKPFYSAEI
PENIQLHSPV VHIQANSPEG LKVFYSITDG DPFNQFTINF NTGVINVVAP LDFEAHPAYK
LSVRATDSLT GVHAEVFVDI IVEDINDNPP LFKKQSYSAA LSEASVIGTS VIQVSATDAD
SGTNRGISYH LIENNSKSHD YFHIDSSTGL ILTARSLDYE QTQQHKLVVR AIDSGMPPLN
SDIIVTVDVT DLNDNPPIFS QLLYEAKISE LAPRGHFVTC VKASDADNSD VDKLEYSILT
GNDHMNFAIN SKTGIITISN LHKQGLKPHY NLNMSVSDGV FRSSAQVLIT VIGANLHSPI
FSQNEYEVEL AENAPLHTLV TEVKATDQDS GTYGHITYHI VNDFAKDRFY TNERGQIFTS
EKLDREKQTE KVIAVSLMAK DAGGKVAFCT VNVILTDDND NAPQFRATEY EVNIGSNVPR
GTSVIKVLAS DADEGTNADI TYAIEAESES VKENLEINAS SGIITTKESL IGLENEFLTF
FVRAVDGGSP QKESVVPVYI RILPPEMPLP KFSEPFYSYT VSEDIPIGAE IDIIQADHKQ
TLVYRLIKGN TPESNRDEFF VIDSQNGRLK LEKSLDHETT KWYQFSVLAQ YTNEDYSVVS
TVDVSIQVKD ANDNKPILES NPYEAFIVEN LPAGTRVIQV KATDLDSGIN GQVTYSLDPS
QELAVIESFA INMETGWIST LKELDHEQCN KYKITVIACD RGEKIQLSSV TVVEVMVTDV
NDNPPRFTAE IYKGTVSEDD PPGGIIAILS TTDADTEESN RQVTYYITGG DPLGQFAVEN
IQNEWKVYVR KPLDREEKDN YLLNITATDG IFATKAVVEV KVLDANDNSP VCEKALYADT
VPEDASPGKL IIQISATDAD IRSNAEITYM LHGTGAEKFK LSPDTGELKT LMPLDREQQA
VYNLLVKATD GGGRFCQADI ILTLEDVNDN APEFTADPYS ITVFENTEPK TLLTRVQATD
ADAGVNRKVH YSLVNSADGQ FSIDELSGIV RLEKPLDREL QAVYTLNLKA VDEGLPRRLS
STGTLVVSVL DINDNPPVFE YSEYSTNVSE DTLVGTEVLQ IYAASRDIET NAEITYAIVN
GNEHGKFSID SATGAIFIIE SLDYESSHEY YLTVEATDGG TPSLSDVVTV NINVTDINDN
TPVFSQDTYT AVISEDAVLE QSVIMVMADD ADGPSNNHIH YSIIDGNQGS PFTIDPTRGE
IKVTKLLDRE KISGYTLTVQ ASDNGNPPRV NTTTVNIDVS DVNDNPPVFS KGNYSIIIQE
NKPIGFSVLQ LVVTDKDSSH NGPPFIFTIL SGNEDNTFQI NQQGVLNTSV ALNRRVRDRY
LLHIKVADNG KPQLSSLAYI DIRVIEESIY PPAILPLEIF ITTFGEEYSG GVIGKIHATD
QDVYDTLTYS LDAKMESLFS VSSTGGKLIA HKRLDVGQYL LNVTVTDGKF TTAADITVHI
RQITQELLNR SIAIHFANLA PEEFIGDYWR NFQRALRNIL GVRRNDIQII SLQPSDPPSS
LNVLLHVEKS SNSLHQIKSL LHKINSSVAD LEEILGVRIL EVFHKLCAGL DCPLKFCEEK
VTVDENVMST HSTARLSFVT PRHHRAAVCL CQDGRCPLAN SMCEGNPCPE GSECVPDPTE
GKYTCVCHGS NPGQCPVGSS VTFTGSSYVK YRLMENENKE EMKLTMRLRT YSIHAVVMYA
RGTDYSILEI NHGRLQYKFD CGSGPGIVSV QSIQINDGQW HSVSLEVDGN YARLVLDRVH
TASGTAPGTL RTLNLDSHVF FGGHIRQQGT RHGRSPQVSN GFRGCMDSIV LNGQELPLNS
NPRNYAHMEE SVDVSPGCLL VAIEGCSSSP CQNGGICNPL TNGGYFCKCG PMFMGTHCDV
SVNPCASNPC LYGGSCIPVS DDFVCQCRGQ YTGQRCQLGP YCKDNPCKNN GKCIDSLDGP
VCECETGFRG ERCLADVDEC IENPCLHGAH CENTYGSYNC NCSHGYGGKH CAETVLNKYI
STSWNISLAE VIGIIVFITV IFLLVGIFVI CRKVISRKKK HQPEPEDKHL ATTTPFLQRP
YFDSKLNKNI YSDIPPQVPV RPISYTPSIP SDSRNNLDRN SFEGSAIPEH PEFSTFNPDA
VHGHRKAVAV CSVAPNLPPP PPSNSPSDSD SIQKPSWDFD YDTKVVDLDP CLSKKPLEEK
ASHPYSARES MSEVQSLSSF QSESCDDNAS VVTVIHLVNA VVDSVEKEVV NLHLKVRTQL
LLEGQQLRSK SFAVPDLSHS RGYHWDTSDW MPNVQLPGIQ EYPNYEVVEE PAPIYTDPNV
IDTDYYPGGY DIESDFPPPP DDFPAPDELP PLPPEYSDQF ESIQPPRDMP AVGSLGSSTR
SRQRFNLNQY LPHHYPADMS EPQNTTSGVS SNFREPYASY SLGYNRDFEA PTVDNMSMSV
YASTASCSDV SACCEMESEV MMSDYESGDD GHFEDVKIPP LDSQQHTEV
//