ID A0A3Q0GUV7_ALLSI Unreviewed; 319 AA.
AC A0A3Q0GUV7;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE SubName: Full=Vacuolar protein sorting-associated protein 37A isoform X2 {ECO:0000313|RefSeq:XP_025063227.1};
GN Name=VPS37A {ECO:0000313|RefSeq:XP_025063227.1};
OS Alligator sinensis (Chinese alligator).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Crocodylia; Alligatoridae; Alligatorinae;
OC Alligator.
OX NCBI_TaxID=38654 {ECO:0000313|Proteomes:UP000189705, ECO:0000313|RefSeq:XP_025063227.1};
RN [1] {ECO:0000313|RefSeq:XP_025063227.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Component of the ESCRT-I complex, a regulator of vesicular
CC trafficking process. Required for the sorting of endocytic
CC ubiquitinated cargos into multivesicular bodies. May be involved in
CC cell growth and differentiation. {ECO:0000256|ARBA:ARBA00025010}.
CC -!- SUBCELLULAR LOCATION: Endosome membrane
CC {ECO:0000256|ARBA:ARBA00004481}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004481}. Late endosome membrane
CC {ECO:0000256|ARBA:ARBA00004633}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004633}.
CC -!- SIMILARITY: Belongs to the VPS37 family.
CC {ECO:0000256|ARBA:ARBA00007617}.
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DR RefSeq; XP_025063227.1; XM_025207442.1.
DR AlphaFoldDB; A0A3Q0GUV7; -.
DR Proteomes; UP000189705; Unplaced.
DR GO; GO:0000813; C:ESCRT I complex; IEA:UniProt.
DR GO; GO:0031902; C:late endosome membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0009056; P:catabolic process; IEA:UniProt.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-UniRule.
DR Gene3D; 1.10.287.660; Helix hairpin bin; 1.
DR InterPro; IPR037202; ESCRT_assembly_dom.
DR InterPro; IPR029012; Helix_hairpin_bin_sf.
DR InterPro; IPR009851; Mod_r.
DR PANTHER; PTHR13678; VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 37; 1.
DR PANTHER; PTHR13678:SF2; VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 37A; 1.
DR Pfam; PF07200; Mod_r; 2.
DR SUPFAM; SSF140111; Endosomal sorting complex assembly domain; 1.
DR PROSITE; PS51314; VPS37_C; 1.
PE 3: Inferred from homology;
KW Endosome {ECO:0000256|ARBA:ARBA00022753};
KW Protein transport {ECO:0000256|ARBA:ARBA00022927};
KW Reference proteome {ECO:0000313|Proteomes:UP000189705};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT DOMAIN 232..319
FT /note="VPS37 C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51314"
SQ SEQUENCE 319 AA; 35719 MW; 3CE34EB44045D934 CRC64;
MPHYFLRTIM HIYASLLPPQ FPQEKPVISV FPPIRHHLMD KQGVYVSCPL ISNFTMHSDL
GKIIQSLLDE FWKNPPVLAP SPTSFPYLYS KPAGMPPYAP QGFPFLPPYP PQDTNRSIAS
VPVAESVPSS YATDKSAAPS YGLIADLPLP VPTTEGLLQV GQNGFSYKMP DVPDTFPELS
DLSISQLTDM NEQEDILLEQ FVNLPQLKQV LTDKDELVKS IEELAKKNLL LEPSLEAKRQ
AVLDKSCSPS ALQARLKVAA HEAEEESDTI AEDFLEGKTE IDDFLSIFME KRTLFHCRRA
KEEKLQQAIA MHSQFLAPL
//
