ID A0A3Q0GW57_ALLSI Unreviewed; 602 AA.
AC A0A3Q0GW57;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=ADP-ribosylation factor-binding protein GGA2 isoform X3 {ECO:0000313|RefSeq:XP_025064004.1};
GN Name=GGA2 {ECO:0000313|RefSeq:XP_025064004.1};
OS Alligator sinensis (Chinese alligator).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Crocodylia; Alligatoridae; Alligatorinae;
OC Alligator.
OX NCBI_TaxID=38654 {ECO:0000313|Proteomes:UP000189705, ECO:0000313|RefSeq:XP_025064004.1};
RN [1] {ECO:0000313|RefSeq:XP_025064004.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Early endosome membrane
CC {ECO:0000256|ARBA:ARBA00004220}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004220}. Endosome membrane
CC {ECO:0000256|ARBA:ARBA00004481}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004481}. Golgi apparatus, trans-Golgi network
CC membrane {ECO:0000256|ARBA:ARBA00004150}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004150}. Membrane
CC {ECO:0000256|ARBA:ARBA00004170}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004170}.
CC -!- SIMILARITY: Belongs to the GGA protein family.
CC {ECO:0000256|ARBA:ARBA00008099}.
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DR RefSeq; XP_025064004.1; XM_025208219.1.
DR AlphaFoldDB; A0A3Q0GW57; -.
DR Proteomes; UP000189705; Unplaced.
DR GO; GO:0031901; C:early endosome membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005802; C:trans-Golgi network; IEA:InterPro.
DR GO; GO:0035091; F:phosphatidylinositol binding; IEA:InterPro.
DR GO; GO:0031267; F:small GTPase binding; IEA:InterPro.
DR GO; GO:0043130; F:ubiquitin binding; IEA:InterPro.
DR GO; GO:0006886; P:intracellular protein transport; IEA:InterPro.
DR GO; GO:0016192; P:vesicle-mediated transport; IEA:InterPro.
DR CDD; cd17010; VHS_GGA2; 1.
DR Gene3D; 1.20.58.160; -; 1.
DR Gene3D; 1.25.40.90; -; 1.
DR Gene3D; 2.60.40.1230; -; 1.
DR InterPro; IPR008152; Clathrin_a/b/g-adaptin_app_Ig.
DR InterPro; IPR013041; Clathrin_app_Ig-like_sf.
DR InterPro; IPR008942; ENTH_VHS.
DR InterPro; IPR008153; GAE_dom.
DR InterPro; IPR004152; GAT_dom.
DR InterPro; IPR038425; GAT_sf.
DR InterPro; IPR027422; GGA1-3.
DR InterPro; IPR002014; VHS_dom.
DR PANTHER; PTHR45905:SF2; ADP-RIBOSYLATION FACTOR-BINDING PROTEIN GGA2; 1.
DR PANTHER; PTHR45905; GOLGI-LOCALIZED, GAMMA-ADAPTIN EAR CONTAINING, ARF BINDING PROTEIN; 1.
DR Pfam; PF02883; Alpha_adaptinC2; 1.
DR Pfam; PF03127; GAT; 1.
DR Pfam; PF00790; VHS; 1.
DR SMART; SM00809; Alpha_adaptinC2; 1.
DR SMART; SM00288; VHS; 1.
DR SUPFAM; SSF49348; Clathrin adaptor appendage domain; 1.
DR SUPFAM; SSF48464; ENTH/VHS domain; 1.
DR SUPFAM; SSF89009; GAT-like domain; 1.
DR PROSITE; PS50180; GAE; 1.
DR PROSITE; PS50909; GAT; 1.
DR PROSITE; PS50179; VHS; 1.
PE 3: Inferred from homology;
KW Golgi apparatus {ECO:0000256|ARBA:ARBA00023034};
KW Protein transport {ECO:0000256|ARBA:ARBA00022927};
KW Reference proteome {ECO:0000313|Proteomes:UP000189705};
KW Transport {ECO:0000256|ARBA:ARBA00022448};
KW Ubl conjugation {ECO:0000256|ARBA:ARBA00022843}.
FT DOMAIN 26..156
FT /note="VHS"
FT /evidence="ECO:0000259|PROSITE:PS50179"
FT DOMAIN 192..281
FT /note="GAT"
FT /evidence="ECO:0000259|PROSITE:PS50909"
FT DOMAIN 473..594
FT /note="GAE"
FT /evidence="ECO:0000259|PROSITE:PS50180"
FT REGION 160..192
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 313..336
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 369..410
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 176..192
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 369..408
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 602 AA; 66483 MW; 459B1EC772E96184 CRC64;
MARIRGALAA GAQRLPLRFA RIRNKATDPS IPEENWECIQ RFCDQVNTDP EGPSLAPRLL
AHKIQSPQEM EALHALTVLE TCVNNCGERF HSEVAKFRFL NELIKVLSPK YFGSWSSEKV
KSRVIEIMFS WTVWFPQEVK IRDAYQMLKK QGLVKQDPKL LEDKILPPPS PRPKNSIFDV
DEEKSKEQEK SAKVSKRLNT LDDVRKSVQL LEELLVRYRR RELSAPDLGR LQDLSEHCEK
LRPLLFRLAS ETVDNDEALA EILQANDQLT QVLGSYKQTV LGHDQDSRAD ATAVQPPQGT
VKSYTLIDFS ELDATSQLPP DPWEDEEAAS RHSSTTSTCL LEEELMSLGL SDSPVIQKPP
PEFSSLQMAG HNGYNQTGNA DTHHSTGLGN GWQDSSPEKN TPCGMAGQLS SLPGTKPFPL
NLSPLKSSLP DLPCSSAADV LFSSLACELK PAAALQDSSL ANLFVPLASI KPSAIPPITV
YDQNGFKAML HFSRDPAPGR VNVLVMVLSL LSTSAQPIQD IVFQAAVPKV MRIKLQPASG
SELPPFNPLL PPAVISQVLL LANPNKDPIR LRYKLTFTQG GRPVSEVGEV TGFPEAELWG
RS
//