ID A0A3Q0GZ74_ALLSI Unreviewed; 4620 AA.
AC A0A3Q0GZ74;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=Protocadherin Fat 1 isoform X3 {ECO:0000313|RefSeq:XP_025063463.1};
GN Name=FAT1 {ECO:0000313|RefSeq:XP_025063463.1};
OS Alligator sinensis (Chinese alligator).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Crocodylia; Alligatoridae; Alligatorinae;
OC Alligator.
OX NCBI_TaxID=38654 {ECO:0000313|Proteomes:UP000189705, ECO:0000313|RefSeq:XP_025063463.1};
RN [1] {ECO:0000313|RefSeq:XP_025063463.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR RefSeq; XP_025063463.1; XM_025207678.1.
DR Proteomes; UP000189705; Unplaced.
DR GO; GO:0005886; C:plasma membrane; IEA:InterPro.
DR GO; GO:0005509; F:calcium ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0007156; P:homophilic cell adhesion via plasma membrane adhesion molecules; IEA:InterPro.
DR CDD; cd11304; Cadherin_repeat; 33.
DR CDD; cd00054; EGF_CA; 4.
DR CDD; cd00110; LamG; 1.
DR Gene3D; 2.60.120.200; -; 1.
DR Gene3D; 2.60.40.60; Cadherins; 34.
DR Gene3D; 2.10.25.10; Laminin; 4.
DR InterPro; IPR002126; Cadherin-like_dom.
DR InterPro; IPR015919; Cadherin-like_sf.
DR InterPro; IPR020894; Cadherin_CS.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR001791; Laminin_G.
DR PANTHER; PTHR24025; DESMOGLEIN FAMILY MEMBER; 1.
DR PANTHER; PTHR24025:SF25; FAT ATYPICAL CADHERIN 1; 1.
DR Pfam; PF00028; Cadherin; 29.
DR Pfam; PF00008; EGF; 1.
DR Pfam; PF07645; EGF_CA; 1.
DR Pfam; PF02210; Laminin_G_2; 1.
DR PRINTS; PR00205; CADHERIN.
DR SMART; SM00112; CA; 34.
DR SMART; SM00181; EGF; 5.
DR SMART; SM00179; EGF_CA; 4.
DR SMART; SM00282; LamG; 1.
DR SUPFAM; SSF49313; Cadherin-like; 34.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR SUPFAM; SSF57196; EGF/Laminin; 4.
DR PROSITE; PS00010; ASX_HYDROXYL; 1.
DR PROSITE; PS00232; CADHERIN_1; 12.
DR PROSITE; PS50268; CADHERIN_2; 33.
DR PROSITE; PS00022; EGF_1; 4.
DR PROSITE; PS01186; EGF_2; 2.
DR PROSITE; PS50026; EGF_3; 5.
DR PROSITE; PS01187; EGF_CA; 1.
DR PROSITE; PS50025; LAM_G_DOMAIN; 1.
PE 4: Predicted;
KW Calcium {ECO:0000256|ARBA:ARBA00022837, ECO:0000256|PROSITE-
KW ProRule:PRU00043};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000189705};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..23
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 24..4620
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5018239935"
FT TRANSMEM 4183..4203
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 36..150
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 151..258
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 369..464
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 465..570
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 578..672
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 719..823
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 824..928
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 929..1035
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1044..1140
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1141..1246
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1247..1358
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1360..1457
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1458..1563
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1564..1668
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1669..1766
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1767..1880
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1881..1980
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1981..2082
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2083..2183
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2184..2284
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2285..2391
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2392..2493
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2494..2597
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2598..2704
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2705..2810
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2811..2919
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2920..3024
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 3025..3126
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 3127..3231
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 3232..3336
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 3337..3441
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 3442..3546
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 3562..3655
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 3791..3828
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 3830..4010
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DOMAIN 4014..4051
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 4053..4089
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 4090..4126
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 4128..4164
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT REGION 4304..4328
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4463..4509
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4596..4620
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4464..4484
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4596..4612
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 3800..3817
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 4041..4050
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 4079..4088
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 4116..4125
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 4154..4163
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 4620 AA; 511086 MW; 68CD919A7A47A6C4 CRC64;
MERYLTMLLL LLLLVQHFGN CEGNQRPHHA SPMQFTKVQY NATVYENSAA KTYVGHPVKM
GIYIRNPLWD IRYKIISGDN ENLFKAEEYV LGNFCFLRIR TKGGNTAILN REVKDHYILT
VKAVEKHTNT EARTKVRVQV LDTNDLRPLF SPTSYSVSLP ENTAIRTSIA RVSATDADIG
TNGEFYYSFK ERTDMFAIHP TSGVVVLTGR LDYSEAKLYE MEILAVDRGM KLYGSSGISS
MARLTVHIEQ ANEHAPVITA VALASSESDK DPTYAVVTVE DSDQGSNGEI ASLSIVAGDP
LQQFKTLRSV PGGKEYKIKA VGHIDWESQP FGYNLTLQAK DKGYPPRFSS VKVIHVTSPQ
FKSGPVRFEK DVYRAEISEF APPNTPVIMV KALPSYPHSK YTFKNTPGKI RFNINPHTGL
ITILEKIKAQ HASHLEVEVM TSDRKASAKV LIKVVSMNSN PPEFMQTSYK ASFDENVPVG
TSVMRVSAKD PDEGENGYVT YSIANLNPLP FVINHFSGII STSEDLDYEL MPRVYNLRIR
ASDWGTPYRR EVEVPVTITL NNLNDNIPLF EKINCEGTIP RDLGVGEQIT TVSAIDADEL
QLVRYQIESG NQLDLFSLNP NSGVLSLKQP LIDGLGAKVS FHSLRITATD GENFARPLYI
NITIAASRKP VDLQCEETGV AKMLAEKLLQ ANKLHSRGEI EDAFFDTHSV NMHPPQFRRT
LPTSVEIRED EPVGSSIILV NATDLDTGFN GKLVYAISGG NDDSHFIVDM ETGMLKILSP
LDREVRDAYT LNITVYDLGI PQKSAWRLLD VKILDANDNR PEFLQNSYFV EVSESKELNS
DIIQIEAIDR DLGPNGEVKY FLLTDTDIFT IDSVTGVVKV VGALDREIQH VHFLKIEARD
QPNEEPQLFS TVLLKLSLED INDNPPQFIP SNYHVKIRED LPEGTIITWL EAYDPDLGQS
SQVRYSLLDN GDGTFDVDKL SGAIRIVQRL DFERKQVYNL TVRAKDKGKP VSLSSTSYVE
VEVVDVNENL HPPQFSIFAD KGLVKEDAPI GSSVMTISAY DEDGGRDGEI KYSIRDGSGV
GVFRIDEEKG IIETADRLDR ETTSHYWLTV YATDQGIVPL SSFIEIYIEV GDVNDNAPQT
TEPVYHPEVM ENSPKDVSVI QIEAYDPDSS SNEKLTYKIT SGNPQGFFSI NPRTGLIATT
SRRLDREQQE EHILEVTVTD NGIPAKSTIA RVIIKVLDEN DSKPQFLQKF YKIRLPERDK
PERERTAKRE PIYRVIAADK DEGPNAEISY SIEDGDEQGK FFIEPKTGVV SSKKFSAAGE
YDILSIKAVD NGRPQKSSTT RLHIEWISKP IPPTEPIFFE EMFFSFTVME SDPVAHMIGV
IAVEPLGAPL WFDITGGNYD SRFDVDKGTG TIIVARPLDA EQKSNYNLTV EATDGTRSIS
TQVYIKVIDT NNHRPQFSTS KYEVVISEDT VPETEILQVT ATDRDEKNKL IYTMQSSTDP
ISLKKFRLDP GTGSLYTSEK LDHEAMHQHI LIVMVRDQDV PVKRNYARIV INVSDTNDHT
PWFTSSSYEG RVYESAAVGS AVLQVTALDK DKGKNAEIVY SIESGNIGNY FIIDPILGTV
KIAKELDRSS REEYNLMVKA TDKGNPPLSE VTSVHIFVTV SDNAAPKFTS KEYSTEISEG
TGIGSFVGMV TAYSQSSVVY EIKDGNIGDA FDINPNSGVV TSQKILDFET LPVYTLTVQG
TNMAGLSTNN TVLVHLQDEN DNVPVFTQAE YIGLVSESAS INSVVLTDKN IPLVIRATDA
DKDSNALLVY QIVEPSVHKY FAIDSSTGAI RTVTSLDYEE TNIFHFSVQV HDMGAPRLFA
EYAANVTIYV IDINDCPPVF SKDLYETSIL VPTYKGVQVI TVNATDADSG AFSQLIYSIT
EGNIGEKFSI DSKTGVITIQ NTTQLRSRYE LAVRASDGRF ASTASVKINV KETKASPLKF
TQSSYSAVVQ ENSTEAKTIA VVTAIGNQMN EPLFYHILNP DSRFKISYTS GVLSTTGIPF
DREQQESFDV VVEVTGEHKP SVVAHVVVKV TVEDINDNAP IFVNLPYYAV VKVDSEVGHI
VRRVTAVDKD MGKNGEVHYY LKEHHEHFQI GPTGEISLKK PFELDTLNKE YLVTVMAKDG
GDPAFSAEVI VPITVMNKAM PVFEKPFYSA EIPENIQLHS PVVHIQANSP EGLKVFYSIT
DGDPFNQFTI NFNTGVINVV APLDFEAHPA YKLSVRATDS LTGVHAEVFV DIIVEDINDN
PPLFKKQSYS AALSEASVIG TSVIQVSATD ADSGTNRGIS YHLIENNSKS HDYFHIDSST
GLILTARSLD YEQTQQHKLV VRAIDSGMPP LNSDIIVTVD VTDLNDNPPI FSQLLYEAKI
SELAPRGHFV TCVKASDADN SDVDKLEYSI LTGNDHMNFA INSKTGIITI SNLHKQGLKP
HYNLNMSVSD GVFRSSAQVL ITVIGANLHS PIFSQNEYEV ELAENAPLHT LVTEVKATDQ
DSGTYGHITY HIVNDFAKDR FYTNERGQIF TSEKLDREKQ TEKVIAVSLM AKDAGGKVAF
CTVNVILTDD NDNAPQFRAT EYEVNIGSNV PRGTSVIKVL ASDADEGTNA DITYAIEAES
ESVKENLEIN ASSGIITTKE SLIGLENEFL TFFVRAVDGG SPQKESVVPV YIRILPPEMP
LPKFSEPFYS YTVSEDIPIG AEIDIIQADH KQTLVYRLIK GNTPESNRDE FFVIDSQNGR
LKLEKSLDHE TTKWYQFSVL AQYTNEDYSV VSTVDVSIQV KDANDNKPIL ESNPYEAFIV
ENLPAGTRVI QVKATDLDSG INGQVTYSLD PSQELAVIES FAINMETGWI STLKELDHEQ
CNKYKITVIA CDRGEKIQLS SVTVVEVMVT DVNDNPPRFT AEIYKGTVSE DDPPGGIIAI
LSTTDADTEE SNRQVTYYIT GGDPLGQFAV ENIQNEWKVY VRKPLDREEK DNYLLNITAT
DGIFATKAVV EVKVLDANDN SPVCEKALYA DTVPEDASPG KLIIQISATD ADIRSNAEIT
YMLHGTGAEK FKLSPDTGEL KTLMPLDREQ QAVYNLLVKA TDGGGRFCQA DIILTLEDVN
DNAPEFTADP YSITVFENTE PKTLLTRVQA TDADAGVNRK VHYSLVNSAD GQFSIDELSG
IVRLEKPLDR ELQAVYTLNL KAVDEGLPRR LSSTGTLVVS VLDINDNPPV FEYSEYSTNV
SEDTLVGTEV LQIYAASRDI ETNAEITYAI VNGNEHGKFS IDSATGAIFI IESLDYESSH
EYYLTVEATD GGTPSLSDVV TVNINVTDIN DNTPVFSQDT YTAVISEDAV LEQSVIMVMA
DDADGPSNNH IHYSIIDGNQ GSPFTIDPTR GEIKVTKLLD REKISGYTLT VQASDNGNPP
RVNTTTVNID VSDVNDNPPV FSKGNYSIII QENKPIGFSV LQLVVTDKDS SHNGPPFIFT
ILSGNEDNTF QINQQGVLNT SVALNRRVRD RYLLHIKVAD NGKPQLSSLA YIDIRVIEES
IYPPAILPLE IFITTFGEEY SGGVIGKIHA TDQDVYDTLT YSLDAKMESL FSVSSTGGKL
IAHKRLDVGQ YLLNVTVTDG KFTTAADITV HIRQITQELL NRSIAIHFAN LAPEEFIGDY
WRNFQRALRN ILGVRRNDIQ IISLQPSDPP SSLNVLLHVE KSSNSLHQIK SLLHKINSSV
ADLEEILGVR ILEVFHKLCA GLDCPLKFCE EKVTVDENVM STHSTARLSF VTPRHHRAAV
CLCQDGRCPL ANSMCEGNPC PEGSECVPDP TEGKYTCVCH GSNPGQCPVG SSVTFTGSSY
VKYRLMENEN KEEMKLTMRL RTYSIHAVVM YARGTDYSIL EINHGRLQYK FDCGSGPGIV
SVQSIQINDG QWHSVSLEVD GNYARLVLDR VHTASGTAPG TLRTLNLDSH VFFGGHIRQQ
GTRHGRSPQV SNGFRGCMDS IVLNGQELPL NSNPRNYAHM EESVDVSPGC LLVAIEGCSS
SPCQNGGICN PLTNGGYFCK CGPMFMGTHC DVSVNPCASN PCLYGGSCIP VSDDFVCQCR
GQYTGQRCQL GPYCKDNPCK NNGKCIDSLD GPVCECETGF RGERCLADVD ECIENPCLHG
AHCENTYGSY NCNCSHGYGG KHCAETVLNK YISTSWNISL AEVIGIIVFI TVIFLLVGIF
VICRKVISRK KKHQPEPEDK HLATTTPFLQ RPYFDSKLNK NIYSDIPPQV PVRPISYTPS
IPSDSRNNLD RNSFEGSAIP EHPEFSTFNP DAVHGHRKAV AVCSVAPNLP PPPPSNSPSD
SDSIQKPSWD FDYDTKVVDL DPCLSKKPLE EKASHPYSAR ESMSEVQSLS SFQSESCDDN
ASVVTVIHLV NAVVDSVEKE ESFAVPDLSH SRGYHWDTSD WMPNVQLPGI QEYPNYEVVE
EPAPIYTDPN VIDTDYYPGG YDIESDFPPP PDDFPAPDEL PPLPPEYSDQ FESIQPPRDM
PAVGSLGSST RSRQRFNLNQ YLPHHYPADM SEPQNTTSGV SSNFREPYAS YSLGYNRDFE
APTVDNMSMS VYASTASCSD VSACCEMESE VMMSDYESGD DGHFEDVKIP PLDSQQHTEV
//
