ID A0A3Q0H076_ALLSI Unreviewed; 1843 AA.
AC A0A3Q0H076;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=Triple functional domain protein isoform X8 {ECO:0000313|RefSeq:XP_025065406.1, ECO:0000313|RefSeq:XP_025065407.1};
GN Name=TRIO {ECO:0000313|RefSeq:XP_025065406.1,
GN ECO:0000313|RefSeq:XP_025065407.1};
OS Alligator sinensis (Chinese alligator).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Crocodylia; Alligatoridae; Alligatorinae;
OC Alligator.
OX NCBI_TaxID=38654 {ECO:0000313|Proteomes:UP000189705, ECO:0000313|RefSeq:XP_025065406.1};
RN [1] {ECO:0000313|RefSeq:XP_025065406.1, ECO:0000313|RefSeq:XP_025065407.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
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DR RefSeq; XP_025065406.1; XM_025209621.1.
DR RefSeq; XP_025065407.1; XM_025209622.1.
DR Proteomes; UP000189705; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR CDD; cd13240; PH1_Kalirin_Trio_like; 1.
DR CDD; cd00160; RhoGEF; 1.
DR CDD; cd00170; SEC14; 1.
DR CDD; cd11852; SH3_Kalirin_1; 1.
DR CDD; cd00176; SPEC; 6.
DR Gene3D; 1.20.58.60; -; 5.
DR Gene3D; 3.40.525.10; CRAL-TRIO lipid binding domain; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR001251; CRAL-TRIO_dom.
DR InterPro; IPR036865; CRAL-TRIO_dom_sf.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR047054; Kalirin_TRIO_PH_1.
DR InterPro; IPR028570; Kalirin_TRIO_SH3_1.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR InterPro; IPR018159; Spectrin/alpha-actinin.
DR InterPro; IPR002017; Spectrin_repeat.
DR PANTHER; PTHR22826:SF117; PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY G MEMBER 4B-RELATED; 1.
DR PANTHER; PTHR22826; RHO GUANINE EXCHANGE FACTOR-RELATED; 1.
DR Pfam; PF13716; CRAL_TRIO_2; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR Pfam; PF16609; SH3-RhoG_link; 1.
DR Pfam; PF00018; SH3_1; 1.
DR Pfam; PF00435; Spectrin; 4.
DR SMART; SM00233; PH; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SMART; SM00516; SEC14; 1.
DR SMART; SM00326; SH3; 1.
DR SMART; SM00150; SPEC; 6.
DR SUPFAM; SSF52087; CRAL/TRIO domain; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR SUPFAM; SSF46966; Spectrin repeat; 6.
DR PROSITE; PS50191; CRAL_TRIO; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50002; SH3; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000189705};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 16..162
FT /note="CRAL-TRIO"
FT /evidence="ECO:0000259|PROSITE:PS50191"
FT DOMAIN 1244..1419
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 1431..1543
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 1608..1673
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT REGION 1553..1603
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1690..1843
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 709..736
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 1580..1603
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1690..1711
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1758..1787
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1788..1807
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1843 AA; 211140 MW; FDFDE5D264765B89 CRC64;
MFSAGFRKND EMKAMEVLPI LKEKVAYLSG GRDKRGGPIL TFPARSNHDR IRQEDLRRLI
SYLACIPSEE VCKRGFTVIV DMRGSKWDSI KPLLKILQES FPCCIHVALI IKPDNFWQKQ
RTNFGSSKFE FETNMVSLEG LTKVVDPSQL TPEFDGCLEY NHEEWIEIRV AFEDYISNAT
HMLSRLEELQ DILSKKELPQ DLEGARNMIE EHSQLKKKVI KAPIEDLDVE GQKLLQRIQS
SESFPKKNSG SGNADLQNLL PKVSTMLDRL HSTRQHLHQM WHVRKVKLDQ CFQLRLFEQD
AEKMFDWITH NKGLFLNSYT EIGTSHPHAM ELQTQHNHFA MNCMNVYVNI NRIMSVANRL
VESGHYASQQ IKQIAGQLEQ EWKAFAAALD ERSTLLDMSS IFHQKAEQYM SNVDSWCKAC
GEVELPSELQ DLEDAIHHHQ GIYEHITLAY SEVSQDGKSL LDKLQRPLTP GSSDSLTASA
NYSKAVHHVL DVIHEVLHHQ RQLENIWQHR KVRLHQRLQL CVFQQDVQQV LDWIENHGEA
FLSKHTGVGK SLHRARALQK RHEDFEEVAQ NTYTNADKLL EAAEQLAQTG ECDPEEIYQA
AHQLEDRIQD FVRRVEQRKI LLDMSVSFHT HVKELWTWLE ELQKELLDDV YAESVEAVQD
LIKRFGQQQQ TTLQVTVNVI KEGEDLIQQL RDSAISSNKT PHNSSISHIE TVLQQLDEAQ
SQMEELFQER KIKLELFLQL RIFERDAIDI ISDLESWNDE LSQQMNDFDT EDLTIAEQRL
QHHADKALTM NNLTFDVIHQ GQDLLQYVNE VQASGVELLC DRDVDMATRV QDLLEFLHEK
QQELDLAAEQ HRKHLEQCVQ LRHLQAEVKQ VLGWIRNGES MLNAGLITAS SLQEAEQLQR
EHEQFQHAIE KTHQSALQVQ QKAEAMLQAN HYDMDMIREC AEKVASHWQQ LMLKMEDRLK
LVNASVAFYK TSEQVCSVLE SLEQEYKREE DWCGGADKLG PNSETDHVTP MISKHLEQKE
AFLKACTLAR RNADVFLKYL HRNSVNMPGM VTHIKAPEQQ VKNILNELFQ RENRVLHYWT
MRKRRLDQCQ QYVVFERSAK QALEWIHDNG EFYLSTHTST GSSIQHTQEL LKEHEEFQIT
AKQTKERVKL LIQLADGFCE KGHAHAAEIK KCVTAVDKRY RDFSLRMEKY RTCLEKALGI
SSDSNKSSKS LQLDIIPASV PGSEVKLRDA AHELNEEKRK SARRKEFIMA ELIQTEKAYV
RDLRECMDTY LWEMTSGVEE IPPGIVNKEH IIFGNMQEIY EFHNNIFLKE LEKYEQLPED
VGHCFVTWAD KFQMYVTYCK NKPDSTQLIL EHAGAYFDEI QQRHGLANSI SSYLIKPVQR
ITKYQLLLKE LLTCCEEGKG EIKDGLEVML SVPKRANDAM HLSMLEGFDE NIESQGELIL
QESFQVWDPK TLIRKGRERH LFLFEMSLVF SKEVKDSSGR SKYIYKSKLF TSELGVTEHV
EGDPCKFALW VGRTPTSDNK IVLKASSIEN KQDWIKHIRE VIQERTIHLK GALKEPIHIP
KTAPTTKQKG RRDGEDLDSQ GEGSSQPDTI SIASRTSQNT LDSDKLSGGC ELTVVIHDFT
ACNSNELTIR RGQTVEVLER PHDKPDWCLV RTTDRSPAAE GLVPCGSLCI AHSRSSMEME
GIFNHKDSLS VSSNDASPPA SVTSLQPHMI GAQSSPGPKR PGNTLRKWLT SPVRRLSSGK
ADGHVKKLAH KHKKSREVRK SADAGSQKDS DDSAATPQDE TTEERGRNEG LSSGTLSKSS
SSGMQSCGEE EGEEGADAVP LPPPMAIQQH SLLQPDSQDD KVD
//
