ID A0A3Q0H0T2_ALLSI Unreviewed; 1675 AA.
AC A0A3Q0H0T2;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE SubName: Full=Tuberin isoform X12 {ECO:0000313|RefSeq:XP_025064040.1};
GN Name=TSC2 {ECO:0000313|RefSeq:XP_025064040.1};
OS Alligator sinensis (Chinese alligator).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Crocodylia; Alligatoridae; Alligatorinae;
OC Alligator.
OX NCBI_TaxID=38654 {ECO:0000313|Proteomes:UP000189705, ECO:0000313|RefSeq:XP_025064040.1};
RN [1] {ECO:0000313|RefSeq:XP_025064040.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_025064040.1; XM_025208255.1.
DR Proteomes; UP000189705; Unplaced.
DR GO; GO:0005634; C:nucleus; IEA:InterPro.
DR GO; GO:0033596; C:TSC1-TSC2 complex; IEA:InterPro.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR GO; GO:0032007; P:negative regulation of TOR signaling; IEA:InterPro.
DR GO; GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR Gene3D; 3.40.50.11210; Rap/Ran-GAP; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR035974; Rap/Ran-GAP_sf.
DR InterPro; IPR000331; Rap/Ran_GAP_dom.
DR InterPro; IPR003913; Tuberin.
DR InterPro; IPR018515; Tuberin-type_domain.
DR InterPro; IPR027107; Tuberin/Ral-act_asu.
DR InterPro; IPR024584; Tuberin_N.
DR PANTHER; PTHR10063; TUBERIN; 1.
DR PANTHER; PTHR10063:SF0; TUBERIN; 1.
DR Pfam; PF11864; DUF3384; 1.
DR Pfam; PF02145; Rap_GAP; 1.
DR Pfam; PF03542; Tuberin; 1.
DR PRINTS; PR01431; TUBERIN.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF111347; Rap/Ran-GAP; 1.
DR PROSITE; PS50085; RAPGAP; 1.
PE 4: Predicted;
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW Reference proteome {ECO:0000313|Proteomes:UP000189705}.
FT DOMAIN 1398..1625
FT /note="Rap-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50085"
FT REGION 567..588
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 844..877
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 954..1003
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1015..1049
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1130..1223
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1238..1356
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1628..1662
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 574..588
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 856..877
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 954..973
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1016..1034
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1130..1155
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1244..1263
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1280..1295
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1304..1322
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1338..1353
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1637..1653
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1675 AA; 187061 MW; 496573EB45C4635C CRC64;
MLQPERPAEA RHAVLHLLKA IVQGQGERLG ILRAHFFRVI KDYPSNEDLH ERLEVFKALT
DNGRYITYLE EELAEFVLQW MEVGLSSEFL LVLVNLVKFN SCYLDDYVAE MVHMICLLCL
RTSSSDDIEV SLQVLDAVVC YNCLPSESLP VFIITLCRTI NVKELSEPCW KLMRNLLGTH
LGHSAIYNMC RIMEVRAYMA DAALLRGAVF FVGMALWGAH RLHSLKNSPT SVLPSFLKAM
TCSNAVVSYE IVLSITRLIK KYGKELQAVT WDILLDIIER LLQQLQSLES PDLKSIVHDL
LTTVEELCDQ NDFHGSEERF FELVERCADQ RPESSVLNLI TYRAQSIYPA KDGWIHNLQL
LMERFFRNES RSVVRIKVLD VLSFVLSINR QFYEEELINA VVISQLAHIP EDKDHKVRKL
ATQLLVDLAE GCNTHHFNSL LDIIEKVAAH SLSSPAELEG RDLLSYSASL EDVKTAVLGL
LIILQTKLYS LPASHATHVY EMLISHIQLH YKCMYSLPVA SSIRLQVFDF LLMLQADSLH
RLGLSNKDGA VRFSPYCLCN LVEPEKRTSD KKPAGTLSPP SGSPSVSSQN ASIRVGHLPY
SLLFGVLLQC LKQETDWKVL KLVLNKLPES LRYKVLFLTS PCNIDQLASA LCSMLTDKKT
ADRLHGMPEG FSRTDLHLAV VPVLTALISY HNYLDKAKQR EIVYCLEHGL IYRCANQCVV
ALSVCSIEMP DIIIKALPIL IVKLTHISAT ANMAIPLLEF LSTLARLPHL YRNFAAEQYA
SVFAISLPYT NPSKFNQYIV CLAHHVIAMW FIRCRLPFRK DFVPYITKGL RSNVLLSFDD
TPEKDSFRAR STSLNERPKS RIQTSITSSS LGSADENSMA QADDNLKNLH LELTETCLDM
MARYVFSNFT AVPKRSPVGE FLLAGGRTKT WLVGNKLVTI TTSVGTGTRS LLGLDSGELQ
SSPESSSDPV LQVRQTKEAP AKLESQAGQQ VCRGSRNRVR SMSGGHALRV GALETSGSHF
PSSSVPQGLQ NPPASAARTE KAASAAQTPL QKEKASLAAY VPLLTQGWAE ILVRRPTGNT
SWLMSLENPL SPFSSDINNM PLQELSNALM AAERFKEHRE TALYKSLSVP SSSLATGTTK
PSLLQRSNTE SAVVLEEGSP SEMELKETDS PTESQEIEDF EATSSEPSLS EEKFGKPKEP
YSRSSSTSSQ EEKSLRSDDL VPVGIPIGRV IHSEDGRALE ELSFQPSQPL SKSSSSPELQ
TLQEVLRDAN GREGIGKLST EVKSKSQSEN LEGEGLGSWL SQGEDAKMTG TASMSSASPR
SPSGYRPRGY TISDSAPSKR GKRIERDAFK SRTAASNAEK VPGINPSFVF LQLYHSPFFG
DESNKPLLLP NETFERSVQL LDQIPSYDTH KIAVLYVGEG QTNNEIAILS NEHGSYRYTE
FLTGLGKLIE LKDCQPDKIY LGGLDVCGED GQFTYCWHDD IMQAIFHIAT LMPTKDLDKY
RCDKKRHLGN DFVSIIYNDS GEDFKLGTIK GQFNFVHVII TPLDYDCNLV TLQCRKDMEG
LVDTSVAKII SDKNLPFVAR QMALHANMAS QVHHSRSNPT DTYPSKWIAR LRHIKRLRHR
LREETQYQAP GFPLQIHPSA PAKPPPHVPQ DPPPTYETGQ RKRLISSVDD FTEFV
//
