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Database: UniProt
Entry: A0A3Q0H314_ALLSI
LinkDB: A0A3Q0H314_ALLSI
Original site: A0A3Q0H314_ALLSI 
ID   A0A3Q0H314_ALLSI        Unreviewed;      1352 AA.
AC   A0A3Q0H314;
DT   13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT   13-FEB-2019, sequence version 1.
DT   24-JAN-2024, entry version 25.
DE   RecName: Full=Tyrosine-protein kinase receptor {ECO:0000256|RuleBase:RU000312};
DE            EC=2.7.10.1 {ECO:0000256|RuleBase:RU000312};
GN   Name=INSR {ECO:0000313|RefSeq:XP_025066097.1};
OS   Alligator sinensis (Chinese alligator).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Crocodylia; Alligatoridae; Alligatorinae;
OC   Alligator.
OX   NCBI_TaxID=38654 {ECO:0000313|Proteomes:UP000189705, ECO:0000313|RefSeq:XP_025066097.1};
RN   [1] {ECO:0000313|RefSeq:XP_025066097.1}
RP   IDENTIFICATION.
RG   RefSeq;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-
CC         [protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA-
CC         COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858,
CC         ChEBI:CHEBI:82620, ChEBI:CHEBI:456216; EC=2.7.10.1;
CC         Evidence={ECO:0000256|ARBA:ARBA00001171,
CC         ECO:0000256|RuleBase:RU000312};
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC       pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC   -!- SIMILARITY: Belongs to the protein kinase superfamily. Tyr protein
CC       kinase family. Insulin receptor subfamily.
CC       {ECO:0000256|RuleBase:RU000312}.
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DR   RefSeq; XP_025066097.1; XM_025210312.1.
DR   STRING; 38654.A0A3Q0H314; -.
DR   InParanoid; A0A3Q0H314; -.
DR   OrthoDB; 1614410at2759; -.
DR   Proteomes; UP000189705; Unplaced.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0043560; F:insulin receptor substrate binding; IEA:InterPro.
DR   GO; GO:0043548; F:phosphatidylinositol 3-kinase binding; IEA:InterPro.
DR   GO; GO:0004714; F:transmembrane receptor protein tyrosine kinase activity; IEA:UniProtKB-EC.
DR   GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR   GO; GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway; IEA:InterPro.
DR   CDD; cd00063; FN3; 3.
DR   CDD; cd00064; FU; 1.
DR   CDD; cd05061; PTKc_InsR; 1.
DR   Gene3D; 2.60.40.10; Immunoglobulins; 4.
DR   Gene3D; 3.80.20.20; Receptor L-domain; 2.
DR   Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR   InterPro; IPR003961; FN3_dom.
DR   InterPro; IPR036116; FN3_sf.
DR   InterPro; IPR006211; Furin-like_Cys-rich_dom.
DR   InterPro; IPR006212; Furin_repeat.
DR   InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR040969; Insulin_TMD.
DR   InterPro; IPR011009; Kinase-like_dom_sf.
DR   InterPro; IPR000719; Prot_kinase_dom.
DR   InterPro; IPR017441; Protein_kinase_ATP_BS.
DR   InterPro; IPR000494; Rcpt_L-dom.
DR   InterPro; IPR036941; Rcpt_L-dom_sf.
DR   InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR   InterPro; IPR008266; Tyr_kinase_AS.
DR   InterPro; IPR020635; Tyr_kinase_cat_dom.
DR   InterPro; IPR016246; Tyr_kinase_insulin-like_rcpt.
DR   InterPro; IPR002011; Tyr_kinase_rcpt_2_CS.
DR   PANTHER; PTHR24416:SF535; INSULIN RECEPTOR; 1.
DR   PANTHER; PTHR24416; TYROSINE-PROTEIN KINASE RECEPTOR; 1.
DR   Pfam; PF00041; fn3; 1.
DR   Pfam; PF00757; Furin-like; 1.
DR   Pfam; PF17870; Insulin_TMD; 1.
DR   Pfam; PF07714; PK_Tyr_Ser-Thr; 1.
DR   Pfam; PF01030; Recep_L_domain; 2.
DR   PIRSF; PIRSF000620; Insulin_receptor; 1.
DR   PRINTS; PR00109; TYRKINASE.
DR   SMART; SM00060; FN3; 3.
DR   SMART; SM00261; FU; 1.
DR   SMART; SM00219; TyrKc; 1.
DR   SUPFAM; SSF49265; Fibronectin type III; 3.
DR   SUPFAM; SSF57184; Growth factor receptor domain; 1.
DR   SUPFAM; SSF52058; L domain-like; 2.
DR   SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR   PROSITE; PS50853; FN3; 2.
DR   PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR   PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR   PROSITE; PS00109; PROTEIN_KINASE_TYR; 1.
DR   PROSITE; PS00239; RECEPTOR_TYR_KIN_II; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|PIRSR:PIRSR000620-2, ECO:0000256|PROSITE-
KW   ProRule:PRU10141}; Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Kinase {ECO:0000256|ARBA:ARBA00023137};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Nucleotide-binding {ECO:0000256|PIRSR:PIRSR000620-2, ECO:0000256|PROSITE-
KW   ProRule:PRU10141}; Phosphoprotein {ECO:0000256|RuleBase:RU000312};
KW   Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU000312};
KW   Reference proteome {ECO:0000313|Proteomes:UP000189705};
KW   Transferase {ECO:0000256|ARBA:ARBA00023137};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU000312};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius};
KW   Tyrosine-protein kinase {ECO:0000256|ARBA:ARBA00023137}.
FT   TRANSMEM        930..954
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          612..714
FT                   /note="Fibronectin type-III"
FT                   /evidence="ECO:0000259|PROSITE:PS50853"
FT   DOMAIN          828..923
FT                   /note="Fibronectin type-III"
FT                   /evidence="ECO:0000259|PROSITE:PS50853"
FT   DOMAIN          993..1268
FT                   /note="Protein kinase"
FT                   /evidence="ECO:0000259|PROSITE:PS50011"
FT   REGION          1297..1352
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   ACT_SITE        1129
FT                   /note="Proton donor/acceptor"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000620-1"
FT   BINDING         1003
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000620-2"
FT   BINDING         1027
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000620-2,
FT                   ECO:0000256|PROSITE-ProRule:PRU10141"
FT   BINDING         1074..1080
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000620-2"
FT   BINDING         1133..1134
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000620-2"
FT   BINDING         1147
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000620-2"
SQ   SEQUENCE   1352 AA;  152666 MW;  53CEEF1A697E91CA CRC64;
     MYLATLGACD AGDGVRPGRK EACAVCKSMD IRNNLTRLNM LENCTVIEGH LQILLMFKTK
     PEDFRELSFP KLTMITDYLL LFRVYGLESL KGLFPNLTVI RGTHLFFNYA LVIFEMVHLK
     EIGLYNLMNI TRGAVRIEKN NELCYLSTID WSRILDSVED NYIVANKDDK EECGDVCPGT
     VKGKSNCPPT VINGIFIERC WTHDRCQRVC PTACKSQGCT SDGRCCHREC LGDCAEPNSP
     EKCVACRNFY LDGTCVETCP PGYYRFEGWR CVTFSFCQDL HNKCKNARES GCHVIHNNEC
     VRECPSGYTM NSSNLHCTPC AGPCPKVCDF GKEKAIDSVT SAQELRGCTI VNGSLVINIR
     GGNNIAAELE ANLGLVEEIS GYLKIRRSYA LVSLSFFRKL HLIKGETLEA GNYSFYALDN
     QNLRQLWDWS KHNLTIARGK LFFHYNPKLC LSEIHKMEEI SGTKGRQERN DIALKTNGDQ
     ASCENELLKF SFIRTSHDKI LLKWEPYWPP DFRDLLGFML FYKEAPYQNV TEFDGQDACG
     SNSWTVLDVD PPPRSNEPKT QGHPGWLLRG LKPWTQYAVF VKTLVTFSDE RRTYGAKSEI
     IYVQTNATVP SVPLDPISVS NSSSQIILKW KPPSEPNGNI THYLVYWQQQ SEDSELYELD
     YCLKGLKLPS RTWSPPFESE DPQKYNQSES EEVSGECCSC PKTDSQIQKE LEESAFRKTF
     ENYLHNEVFV PRPSRKRRDL GTVANATVVM PTITSSPNTS AAASGNTEEQ KPFEKVMFKE
     STVISGLRHF TGYRIELHAC NHDAQESRCS VAAYVSARTM PEAKADDIVG PVSHELVEKN
     AVHLKWQEPK EPNGLIVLYE VNYGRLGESE EAHYCVSRKQ FASEQGCKLR ALQPGNYSVR
     VRATSLAGNG SWTEPTYFYV ADYLNAQPNI AVIVVPIIFA SIIIGAIGIV YVLVKKRQTE
     GPTGPLYASS NPEYLSASDV YVPDEWEVAR DKIALLRELG QGSFGMVYEG IAKDIVKGEP
     ETRVAVKTVN ESASLRERIE FLNEASVMKG FSCHHVVRLL GVVSKGQPTL VVMELMAHGD
     MKSYLRSLRP DAENNPGRPP PTLREMIQMA AEIADGMAYL NAKKFVHRDL AARNCMVAED
     FTVKIGDFGM TRDIYETDYY RKGGKGLLPV RWMAPESLKD GVFTTYSDVW SFGVVLWEIS
     SLAEQPYQGL SNEQVLKFVM DGGYLDQPDN CPERLHSLMQ MCWQYNPRMR PTFIEIIEML
     KEDLHPSFQE VSFFYSEENK PPDTEEFEMD FENMESIPLD PSSYSQRDKV LGRDNGPSMG
     LKGNYEEHIP YTHMNGGKKN GRILSMPRSS PS
//
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