ID A0A3Q0H3R8_ALLSI Unreviewed; 376 AA.
AC A0A3Q0H3R8;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE SubName: Full=Integrin-linked kinase-associated serine/threonine phosphatase 2C {ECO:0000313|RefSeq:XP_025065045.1};
GN Name=ILKAP {ECO:0000313|RefSeq:XP_025065045.1};
OS Alligator sinensis (Chinese alligator).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Crocodylia; Alligatoridae; Alligatorinae;
OC Alligator.
OX NCBI_TaxID=38654 {ECO:0000313|Proteomes:UP000189705, ECO:0000313|RefSeq:XP_025065045.1};
RN [1] {ECO:0000313|RefSeq:XP_025065045.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|ARBA:ARBA00001946};
CC -!- COFACTOR:
CC Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC Evidence={ECO:0000256|ARBA:ARBA00001936};
CC -!- SIMILARITY: Belongs to the PP2C family.
CC {ECO:0000256|RuleBase:RU003465}.
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DR RefSeq; XP_025065045.1; XM_025209260.1.
DR AlphaFoldDB; A0A3Q0H3R8; -.
DR STRING; 38654.A0A3Q0H3R8; -.
DR KEGG; asn:102379320; -.
DR InParanoid; A0A3Q0H3R8; -.
DR OrthoDB; 202023at2759; -.
DR Proteomes; UP000189705; Unplaced.
DR GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0004722; F:protein serine/threonine phosphatase activity; IEA:InterPro.
DR GO; GO:0007229; P:integrin-mediated signaling pathway; IEA:UniProtKB-KW.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd00143; PP2Cc; 1.
DR Gene3D; 3.60.40.10; PPM-type phosphatase domain; 1.
DR InterPro; IPR015655; PP2C.
DR InterPro; IPR000222; PP2C_BS.
DR InterPro; IPR036457; PPM-type-like_dom_sf.
DR InterPro; IPR001932; PPM-type_phosphatase-like_dom.
DR PANTHER; PTHR47992; PROTEIN PHOSPHATASE; 1.
DR PANTHER; PTHR47992:SF105; PROTEIN PHOSPHATASE 1B; 1.
DR Pfam; PF00481; PP2C; 1.
DR SMART; SM00332; PP2Cc; 1.
DR SUPFAM; SSF81606; PP2C-like; 1.
DR PROSITE; PS01032; PPM_1; 1.
DR PROSITE; PS51746; PPM_2; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|RuleBase:RU003465};
KW Integrin {ECO:0000313|RefSeq:XP_025065045.1};
KW Kinase {ECO:0000313|RefSeq:XP_025065045.1};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Protein phosphatase {ECO:0000256|ARBA:ARBA00022912,
KW ECO:0000256|RuleBase:RU003465};
KW Reference proteome {ECO:0000313|Proteomes:UP000189705};
KW Transferase {ECO:0000313|RefSeq:XP_025065045.1}.
FT DOMAIN 92..374
FT /note="PPM-type phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS51746"
FT REGION 1..75
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 56..75
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|RefSeq:XP_025065045.1"
SQ SEQUENCE 376 AA; 41425 MW; 8659D92D8EFC73E1 CRC64;
CFSGKEAQKG SLLFDDLPPV SSTDSGKGGP LLFDDLPPAS SGDSAFCTTE QVSVGSHGKG
KKRKSSEEEK NGSEELVEKK VCKGSAGIFA LKGYVAERKG EREEMQDAHV ILNDITEECR
PLPSQVTRVS YFAVFDGHGG VRASKFAAQN LHQNLIKKLP KGEVVSVEKT VRRCLLDTFK
HTDEEFLKQA SSQKPAWKDG STATCVLAVD NILYIASLGD SRAILCRYNE ESQKHSALSL
SKEHNPTQYE ERMRIQKAGG NVRDGRVLGV LEVSRSIGDG QYKRCGVISV PDIKRCQLSY
NDRFILIACD GLFKVFTPEE AVNFILSCLE DKNIQMREGK LEVDARYEAA CNRLANKAVQ
RGSADNVTVM VVRIEH
//
