ID A0A3Q0H4C1_ALLSI Unreviewed; 395 AA.
AC A0A3Q0H4C1;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=Transcription factor E2F4 {ECO:0000313|RefSeq:XP_025065218.1};
GN Name=E2F4 {ECO:0000313|RefSeq:XP_025065218.1};
OS Alligator sinensis (Chinese alligator).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Crocodylia; Alligatoridae; Alligatorinae;
OC Alligator.
OX NCBI_TaxID=38654 {ECO:0000313|Proteomes:UP000189705, ECO:0000313|RefSeq:XP_025065218.1};
RN [1] {ECO:0000313|RefSeq:XP_025065218.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|RuleBase:RU003796}.
CC -!- SIMILARITY: Belongs to the E2F/DP family.
CC {ECO:0000256|ARBA:ARBA00010940, ECO:0000256|RuleBase:RU003796}.
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DR RefSeq; XP_025065218.1; XM_025209433.1.
DR AlphaFoldDB; A0A3Q0H4C1; -.
DR STRING; 38654.A0A3Q0H4C1; -.
DR KEGG; asn:102381316; -.
DR InParanoid; A0A3Q0H4C1; -.
DR OrthoDB; 1761at2759; -.
DR Proteomes; UP000189705; Unplaced.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005667; C:transcription regulator complex; IEA:InterPro.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IEA:InterPro.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR CDD; cd14660; E2F_DD; 1.
DR Gene3D; 6.10.250.540; -; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR015633; E2F.
DR InterPro; IPR037241; E2F-DP_heterodim.
DR InterPro; IPR032198; E2F_CC-MB.
DR InterPro; IPR003316; E2F_WHTH_DNA-bd_dom.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR12081; TRANSCRIPTION FACTOR E2F; 1.
DR PANTHER; PTHR12081:SF42; TRANSCRIPTION FACTOR E2F4; 1.
DR Pfam; PF16421; E2F_CC-MB; 1.
DR Pfam; PF02319; E2F_TDP; 1.
DR SMART; SM01372; E2F_TDP; 1.
DR SUPFAM; SSF144074; E2F-DP heterodimerization region; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|RuleBase:RU003796};
KW Nucleus {ECO:0000256|RuleBase:RU003796};
KW Reference proteome {ECO:0000313|Proteomes:UP000189705};
KW Transcription {ECO:0000256|ARBA:ARBA00023163,
KW ECO:0000256|RuleBase:RU003796};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015,
KW ECO:0000256|RuleBase:RU003796}.
FT DOMAIN 25..79
FT /note="E2F/DP family winged-helix DNA-binding"
FT /evidence="ECO:0000259|SMART:SM01372"
FT REGION 213..270
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 294..323
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 86..120
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 232..270
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 294..315
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|RefSeq:XP_025065218.1"
SQ SEQUENCE 395 AA; 43438 MW; 6394C43CBA206A70 CRC64;
AFPPRWPRPV SLHFTPAGRP LGERQAQELV GSLCRRLLAC KAADTLAVRQ KRRIYDITNV
LEGIGLIEKK SKNSIQWKGV GPGCNTREIA HKLIELKAEI EELEQREQEL EQQKMWVQQS
IKNVTEDVQN NRLAYVTHED ICKCFTGDTL LAIRAPSGTR LEVPIPEGLN GQTKYQIHLK
STSGPIDVLL VNKDAWSSPP VVLPVPPPED LIQCQPAVPS KPPVPPLAHF QEASVPSSTQ
PSTPTPTSTQ DHSPATQKTT STECSISVSE SKSTSDFDQL SLVSASATRT AALDTQPLQS
SASLDSSSIL PNPSTSFEPI KPDPTEILEL PKELSEMFDP TRECMNSELL EELMSSEVFA
PLLRLSPPPG DHDYIYNLDE SEGVCDLFDV PVLNL
//
