ID   A0A3Q0H5W1_ALLSI        Unreviewed;       813 AA.
AC   A0A3Q0H5W1;
DT   13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT   13-FEB-2019, sequence version 1.
DT   27-MAR-2024, entry version 17.
DE   SubName: Full=Rap guanine nucleotide exchange factor 5 isoform X1 {ECO:0000313|RefSeq:XP_025065803.1};
GN   Name=RAPGEF5 {ECO:0000313|RefSeq:XP_025065803.1};
OS   Alligator sinensis (Chinese alligator).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Crocodylia; Alligatoridae; Alligatorinae;
OC   Alligator.
OX   NCBI_TaxID=38654 {ECO:0000313|Proteomes:UP000189705, ECO:0000313|RefSeq:XP_025065803.1};
RN   [1] {ECO:0000313|RefSeq:XP_025065803.1}
RP   IDENTIFICATION.
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
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DR   RefSeq; XP_025065803.1; XM_025210018.1.
DR   AlphaFoldDB; A0A3Q0H5W1; -.
DR   STRING; 38654.A0A3Q0H5W1; -.
DR   InParanoid; A0A3Q0H5W1; -.
DR   OrthoDB; 5473909at2759; -.
DR   Proteomes; UP000189705; Unplaced.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR   GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR   CDD; cd04437; DEP_Epac; 1.
DR   CDD; cd00155; RasGEF; 1.
DR   CDD; cd06224; REM; 1.
DR   Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR   Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 1.
DR   Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR   InterPro; IPR000591; DEP_dom.
DR   InterPro; IPR008937; Ras-like_GEF.
DR   InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR   InterPro; IPR019804; Ras_G-nucl-exch_fac_CS.
DR   InterPro; IPR023578; Ras_GEF_dom_sf.
DR   InterPro; IPR001895; RASGEF_cat_dom.
DR   InterPro; IPR036964; RASGEF_cat_dom_sf.
DR   InterPro; IPR029071; Ubiquitin-like_domsf.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR   PANTHER; PTHR23113:SF26; RAP GUANINE NUCLEOTIDE EXCHANGE FACTOR 5; 1.
DR   Pfam; PF00610; DEP; 1.
DR   Pfam; PF00617; RasGEF; 1.
DR   Pfam; PF00618; RasGEF_N; 1.
DR   SMART; SM00049; DEP; 1.
DR   SMART; SM00147; RasGEF; 1.
DR   SMART; SM00229; RasGEFN; 1.
DR   SUPFAM; SSF48366; Ras GEF; 1.
DR   SUPFAM; SSF54236; Ubiquitin-like; 1.
DR   SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR   PROSITE; PS50186; DEP; 1.
DR   PROSITE; PS00720; RASGEF; 1.
DR   PROSITE; PS50009; RASGEF_CAT; 1.
DR   PROSITE; PS50212; RASGEF_NTER; 1.
PE   4: Predicted;
KW   Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW   ECO:0000256|PROSITE-ProRule:PRU00168};
KW   Reference proteome {ECO:0000313|Proteomes:UP000189705}.
FT   DOMAIN          43..112
FT                   /note="DEP"
FT                   /evidence="ECO:0000259|PROSITE:PS50186"
FT   DOMAIN          300..433
FT                   /note="N-terminal Ras-GEF"
FT                   /evidence="ECO:0000259|PROSITE:PS50212"
FT   DOMAIN          577..812
FT                   /note="Ras-GEF"
FT                   /evidence="ECO:0000259|PROSITE:PS50009"
SQ   SEQUENCE   813 AA;  93838 MW;  B4A37A7178E40AC2 CRC64;
     MTLSRRISNP YLENPSSKIY GESSSCAGRA LRNIFTVQAS DLIKDRVYLT GICRRSCVGS
     QLVDWLLQHC PFVKCRSTAV GVWQLLLDMG IVLSVDRELC FQDTYAFYQF SADECTYLFC
     EFERDEEWQN GVKLLLQLVP LTPPRITACN LPDQKIEDAA ETEAEILARL TSAVQRELAA
     VIALKARKSA IHQNEENNSP EDLQDTSDAQ AGVLCKLQER DDIGRIELVQ KLAKENYPFL
     QADRKEPANT EQVPCDLAVA KPDDEVTTVQ EKEQDQDVLV LRKVSSHSSA PTSGCAENDW
     RYVVVSGTPE KILEHLLNDL HLEAAQDKET ETLLDDFLLT YTVFMTTDDL CQALLRHYCA
     KNIQGKEENS DVPCRKRKVL HLVSQWTSLY KDWLHEDEHL KQFLKTIYRN VLDDVYEYPI
     LEKELKEFQK ILGTHRRHTV DEYSPHRKNK AFFHQFSLKE NWLQHRGTVN ETEEIFCRIY
     ITEHSYVSVK TKVSASAQEI LKIVAEKIQH AEEDLALVVV TFSGEKHELQ PNDLALSKSL
     ESSSRMFVYR KDLNDTLNPF AENEELQQRS VRILGINTWD LALELTNFDW SLFNSIHEQE
     LIYFTFSRQG SGENTVNLSL LLQRCNEVQL WVATEILLCS QLCKRVQLVK KFIKIAAHCK
     AQRNLNSFFA IVMGLNTASV SRLSQTWEKI PGKFKKLFTE LESLTDPSLN HKAYRDAFKK
     MKSPKIPFMP LLLKDVTFIH EGNKTFLDNL VNFEKLHMIA DTVRSLRHCR NNQFGNEVPP
     KEHQELKPYV HHLRVIDNQQ TLFELSHRIE PRV
//