ID   A0A3Q0H6G1_ALLSI        Unreviewed;       610 AA.
AC   A0A3Q0H6G1;
DT   13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT   13-FEB-2019, sequence version 1.
DT   27-MAR-2024, entry version 16.
DE   RecName: Full=Anoctamin {ECO:0000256|RuleBase:RU280814};
GN   Name=ANO10 {ECO:0000313|RefSeq:XP_025067641.1};
OS   Alligator sinensis (Chinese alligator).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Crocodylia; Alligatoridae; Alligatorinae;
OC   Alligator.
OX   NCBI_TaxID=38654 {ECO:0000313|Proteomes:UP000189705, ECO:0000313|RefSeq:XP_025067641.1};
RN   [1] {ECO:0000313|RefSeq:XP_025067641.1}
RP   IDENTIFICATION.
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141,
CC       ECO:0000256|RuleBase:RU280814}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU280814}.
CC   -!- SIMILARITY: Belongs to the anoctamin family.
CC       {ECO:0000256|ARBA:ARBA00009671, ECO:0000256|RuleBase:RU280814}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC       feature annotation. {ECO:0000256|RuleBase:RU280814}.
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DR   RefSeq; XP_025067641.1; XM_025211856.1.
DR   AlphaFoldDB; A0A3Q0H6G1; -.
DR   Proteomes; UP000189705; Unplaced.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR007632; Anoctamin.
DR   InterPro; IPR049452; Anoctamin_TM.
DR   PANTHER; PTHR12308; ANOCTAMIN; 1.
DR   PANTHER; PTHR12308:SF40; ANOCTAMIN-10; 1.
DR   Pfam; PF04547; Anoctamin; 1.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU280814};
KW   Reference proteome {ECO:0000313|Proteomes:UP000189705};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU280814};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|RuleBase:RU280814}.
FT   TRANSMEM        217..237
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU280814"
FT   TRANSMEM        243..261
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU280814"
FT   TRANSMEM        314..337
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU280814"
FT   TRANSMEM        357..377
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU280814"
FT   TRANSMEM        400..421
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU280814"
FT   TRANSMEM        433..455
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU280814"
FT   TRANSMEM        501..524
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU280814"
FT   DOMAIN          200..602
FT                   /note="Anoctamin transmembrane"
FT                   /evidence="ECO:0000259|Pfam:PF04547"
SQ   SEQUENCE   610 AA;  71095 MW;  F229D95543B5DCB5 CRC64;
     MKESWSAFDT FEPHFRPLVV IELAKDTKEE TKEWLTQRIE DKKKNGGAQL LVKPLAKEDG
     GKIDGNENIY LVGASYLRLL LGAETVGLVK ECNDNSMRTF TYSSRKTFKD FAEDNHNFLT
     MSECQYIIKH ELENLRAKDE KMIPGYPQAK LYPGKSIVRR LLTNGILIQF FPLHDKEELK
     KLRHIWYSRV KISFQPLDEI RCYFGETIAL YFGFLEYFTF ALVPMALIGI PYYVFAWEDY
     DKYVMFASFN LLWSTVILEV WKRCCARMTY RWGTLLMKRQ FEEPRPGFHG VLGINPVTGK
     EEPVYSSIKR QLRIYLVSLP FVCLCLYLSL YVMMIYFDME QLALDYHEEN ETSFSNLMLF
     VPSIIYAVVI EIMNRIYRYA AEFLTSWENH RLESSHQNHL ILKVLVFNFL NCFASLFYIA
     FVLFDMKLLR QSLATLLITS QILNQFAEAL FPYWLQKRHN KKIKKRMCAS KMDSDLSLFE
     QINMEKEMGT YLGTFDDYLE LFLQFGYVSL FSCVYPLAAV FAVLNNITET YSDALKMCKI
     FKRPFSEPTA NIGVWQLAFE TMSVISVVTN CALIGMSSQV NAIFPESKTD LILIVVLVEH
     CLSGRTDASY
//