ID A0A3Q0H7X4_ALLSI Unreviewed; 562 AA.
AC A0A3Q0H7X4;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE RecName: Full=Transporter {ECO:0000256|RuleBase:RU003732};
GN Name=SLC6A8 {ECO:0000313|RefSeq:XP_025066548.1};
OS Alligator sinensis (Chinese alligator).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Crocodylia; Alligatoridae; Alligatorinae;
OC Alligator.
OX NCBI_TaxID=38654 {ECO:0000313|Proteomes:UP000189705, ECO:0000313|RefSeq:XP_025066548.1};
RN [1] {ECO:0000313|RefSeq:XP_025066548.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the sodium:neurotransmitter symporter (SNF) (TC
CC 2.A.22) family. {ECO:0000256|RuleBase:RU003732}.
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DR RefSeq; XP_025066548.1; XM_025210763.1.
DR AlphaFoldDB; A0A3Q0H7X4; -.
DR Proteomes; UP000189705; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015293; F:symporter activity; IEA:UniProtKB-KW.
DR GO; GO:0006811; P:monoatomic ion transport; IEA:UniProtKB-KW.
DR InterPro; IPR000175; Na/ntran_symport.
DR InterPro; IPR037272; SNS_sf.
DR PANTHER; PTHR11616:SF96; SODIUM- AND CHLORIDE-DEPENDENT CREATINE TRANSPORTER 1; 1.
DR PANTHER; PTHR11616; SODIUM/CHLORIDE DEPENDENT TRANSPORTER; 1.
DR Pfam; PF00209; SNF; 1.
DR PRINTS; PR00176; NANEUSMPORT.
DR SUPFAM; SSF161070; SNF-like; 1.
DR PROSITE; PS00610; NA_NEUROTRAN_SYMP_1; 1.
DR PROSITE; PS50267; NA_NEUROTRAN_SYMP_3; 1.
PE 3: Inferred from homology;
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000189705};
KW Symport {ECO:0000256|RuleBase:RU003732};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU003732};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU003732}.
FT TRANSMEM 46..64
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 76..97
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 217..236
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 248..272
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 292..317
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 329..354
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 374..400
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 432..450
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 462..485
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 1..35
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 18..33
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 562 AA; 61441 MW; EDB9894BDD154B8C CRC64;
MCQEEGAGLV AEDPLRLPPS APALPPSPGA TTSPPPRETW ARQMDFIMSC VGFAVGLGNV
WRFPYLCYRN GGGVFLIPYL LMAVLGGVPI FFLEISLGQF MKAGSLSAWN IAPLFKGLGL
ASLLIVFYCN TYYVLVLSWA LFYLGSAVAG AVASGGDLPW ATCGHSWNSP ACHDGPLGNS
SHSNSSQSDA PFRSPVLEFW ENRVLGLSGG LEEPGRLRGD LVLCLVVCWA LVYFCVWKGI
RSAGKQVVYV TALLPYVVLL ALLVRGAMLP GAATGVRFYL QPDWAQLARP QVWIDAGTQI
FFSYAIGLGA LTALGSYNRF HNDCYRDSLL LAVINSGTSF FAGFVVFCVL GFMAHEQGTD
VGPVADSGPG LAFIAYPRAV ALMPVAPLWA ALFFIMLLML GLDSQFVGVE GFVTGILDVV
PPAYQFRFQR EVMVLLCCLV CFCIDLSMVT EGGMYVFQLF DYYSASGTTL LWQAFWESVI
IAWVYGADRF LDDVSCMIGY RPSRWMKWCW MVLTPLVCLR WRRLTQPVFG LHHLEYKVRG
ASGGPSPVED GNTKAVILES IM
//
