ID   A0A3Q0H8J9_ALLSI        Unreviewed;       801 AA.
AC   A0A3Q0H8J9;
DT   13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT   13-FEB-2019, sequence version 1.
DT   27-MAR-2024, entry version 20.
DE   SubName: Full=2-oxoglutarate dehydrogenase-like, mitochondrial isoform X6 {ECO:0000313|RefSeq:XP_025066768.1};
GN   Name=OGDHL {ECO:0000313|RefSeq:XP_025066768.1};
OS   Alligator sinensis (Chinese alligator).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Crocodylia; Alligatoridae; Alligatorinae;
OC   Alligator.
OX   NCBI_TaxID=38654 {ECO:0000313|Proteomes:UP000189705, ECO:0000313|RefSeq:XP_025066768.1};
RN   [1] {ECO:0000313|RefSeq:XP_025066768.1}
RP   IDENTIFICATION.
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- COFACTOR:
CC       Name=thiamine diphosphate; Xref=ChEBI:CHEBI:58937;
CC         Evidence={ECO:0000256|ARBA:ARBA00001964};
CC   -!- SIMILARITY: Belongs to the alpha-ketoglutarate dehydrogenase family.
CC       {ECO:0000256|ARBA:ARBA00006936}.
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DR   RefSeq; XP_025066768.1; XM_025210983.1.
DR   AlphaFoldDB; A0A3Q0H8J9; -.
DR   Proteomes; UP000189705; Unplaced.
DR   GO; GO:0004591; F:oxoglutarate dehydrogenase (succinyl-transferring) activity; IEA:UniProtKB-EC.
DR   GO; GO:0030976; F:thiamine pyrophosphate binding; IEA:InterPro.
DR   GO; GO:0006099; P:tricarboxylic acid cycle; IEA:InterPro.
DR   CDD; cd02016; TPP_E1_OGDC_like; 1.
DR   Gene3D; 3.40.50.12470; -; 1.
DR   Gene3D; 3.40.50.970; -; 1.
DR   Gene3D; 3.40.50.11610; Multifunctional 2-oxoglutarate metabolism enzyme, C-terminal domain; 1.
DR   InterPro; IPR011603; 2oxoglutarate_DH_E1.
DR   InterPro; IPR001017; DH_E1.
DR   InterPro; IPR031717; KGD_C.
DR   InterPro; IPR042179; KGD_C_sf.
DR   InterPro; IPR029061; THDP-binding.
DR   InterPro; IPR005475; Transketolase-like_Pyr-bd.
DR   NCBIfam; TIGR00239; 2oxo_dh_E1; 1.
DR   PANTHER; PTHR23152; 2-OXOGLUTARATE DEHYDROGENASE; 1.
DR   PANTHER; PTHR23152:SF5; 2-OXOGLUTARATE DEHYDROGENASE-LIKE, MITOCHONDRIAL; 1.
DR   Pfam; PF00676; E1_dh; 1.
DR   Pfam; PF16870; OxoGdeHyase_C; 1.
DR   Pfam; PF02779; Transket_pyr; 1.
DR   PIRSF; PIRSF000157; Oxoglu_dh_E1; 1.
DR   SMART; SM00861; Transket_pyr; 1.
DR   SUPFAM; SSF52518; Thiamin diphosphate-binding fold (THDP-binding); 2.
PE   3: Inferred from homology;
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW   Reference proteome {ECO:0000313|Proteomes:UP000189705};
KW   Thiamine pyrophosphate {ECO:0000256|ARBA:ARBA00023052};
KW   Transit peptide {ECO:0000256|ARBA:ARBA00022946}.
FT   DOMAIN          429..642
FT                   /note="Transketolase-like pyrimidine-binding"
FT                   /evidence="ECO:0000259|SMART:SM00861"
SQ   SEQUENCE   801 AA;  91727 MW;  09C6856FBA57A544 CRC64;
     MFINDVEQCQ WIRQKFETPG VMKFTNEEKR TLLARLVRSM RFEDFLARKW SSEKRFGLEG
     CEVMIPALKT IIDKSSEMGI EYVIMGMPHR GRLNVLANVI RKELEQIFCQ FDPKLEAADE
     GSGDVKYHLG MYHERINRAT NKKITLSLVA NPSHLEAVDP VVQGKTKAEQ FYRGDTEGKK
     VMSILLHGDA AFAGQGVVYE TFHLSDLPSY TTNGTIHVVV NNQIGFTTDP RMARSSPYPT
     DVARVVNAPI FHVNADDPEA VMYVCNVAAE WRNTFNKDVV VDLVCYRRRG HNEMDEPMFT
     QPLMYKQIHK QVPVLKKYAD KLIADGTVTL QEFEEEIAKY DRICEEAYTR SKDKKILHIK
     HWLDSPWPGF FNLDGEPKSM TCTPTGIAED MLTHIGSIAS SVPLEDFKIH TGLSRILKAR
     MEMTKNRVVD WALAEYMAFG SLLKEGIHVR LSGQDVERGT FSHRHHVLHD QEVDKRTCVP
     MNHLWEQQAP YTVCNSSLSE YGVLGFELGF AMASPNALVC WEAQFGDFHN TAQCIIDQFI
     SSGQAKWVRH NGIVLLLPHG MEGMGPEHSS ARPERFLQMS NDDPDAYPEF SEHFEVSQLY
     ECNWIVVNCS TPANYFHVLR RQISLPFRKP LIILTPKSLL RHPEAKSSFD EMVSGMSFRR
     VIPEEGIAVE VPNKVKRVIF CTGKVYYDLL KERKNQDLEG QVALTRLEQI SPFPFDLLKE
     ELERYPGADL VWCQEEHKNS GFYDYVKPRF RTIVNHTRPI WYVGREPAAA SATGNKNTHM
     VSLRKFLDTA FNLEAFEGKM F
//