ID A0A3Q0H8L6_ALLSI Unreviewed; 282 AA.
AC A0A3Q0H8L6;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 17.
DE RecName: Full=Regulation of nuclear pre-mRNA domain-containing protein 1A {ECO:0000256|ARBA:ARBA00035704};
DE AltName: Full=Cyclin-dependent kinase inhibitor 2B-related protein {ECO:0000256|ARBA:ARBA00035714};
DE AltName: Full=p15INK4B-related protein {ECO:0000256|ARBA:ARBA00035724};
GN Name=RPRD1A {ECO:0000313|RefSeq:XP_025066788.1};
OS Alligator sinensis (Chinese alligator).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Crocodylia; Alligatoridae; Alligatorinae;
OC Alligator.
OX NCBI_TaxID=38654 {ECO:0000313|Proteomes:UP000189705, ECO:0000313|RefSeq:XP_025066788.1};
RN [1] {ECO:0000313|RefSeq:XP_025066788.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Interacts with phosphorylated C-terminal heptapeptide repeat
CC domain (CTD) of the largest RNA polymerase II subunit POLR2A, and
CC participates in dephosphorylation of the CTD by RPAP2. May act as a
CC negative regulator of cyclin-D1 (CCND1) and cyclin-E (CCNE1) in the
CC cell cycle. {ECO:0000256|ARBA:ARBA00035622}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the UPF0400 (RTT103) family.
CC {ECO:0000256|ARBA:ARBA00034310}.
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DR RefSeq; XP_025066788.1; XM_025211003.1.
DR AlphaFoldDB; A0A3Q0H8L6; -.
DR Proteomes; UP000189705; Unplaced.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0099122; F:RNA polymerase II C-terminal domain binding; IEA:InterPro.
DR CDD; cd17011; CID_RPRD1A; 1.
DR Gene3D; 1.25.40.90; -; 1.
DR Gene3D; 6.10.250.2560; -; 1.
DR InterPro; IPR006569; CID_dom.
DR InterPro; IPR008942; ENTH_VHS.
DR InterPro; IPR032337; RPRD1A/B_C.
DR InterPro; IPR047884; RPRD1A_CID.
DR PANTHER; PTHR12460; CYCLIN-DEPENDENT KINASE INHIBITOR-RELATED PROTEIN; 1.
DR PANTHER; PTHR12460:SF2; REGULATION OF NUCLEAR PRE-MRNA DOMAIN-CONTAINING PROTEIN 1A; 1.
DR Pfam; PF04818; CID; 1.
DR Pfam; PF16566; CREPT; 1.
DR SMART; SM00582; RPR; 1.
DR SUPFAM; SSF48464; ENTH/VHS domain; 1.
DR PROSITE; PS51391; CID; 1.
PE 3: Inferred from homology;
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000189705}.
FT DOMAIN 1..133
FT /note="CID"
FT /evidence="ECO:0000259|PROSITE:PS51391"
SQ SEQUENCE 282 AA; 32169 MW; 21575CE09C8B180B CRC64;
MSAFSESALE RKLSELSNSQ QSVQTLSLWL IHHRKHSALI VSVWERELRK AKSNRKLTFL
YLANDVIQNS KRKGPEFTKD FAPVIVEAFK HVSSESDESC KKHLGRVLSI WEERSVYEND
VLEQLRQALY GDKKGKKRTY EQIQVEDNNC SARSSPTDPP QVDTTDLIRA LQELENAASG
DAAVHQRIAS LPIEVQDVSL LDRITDKESG EQLSKMVDDA CMLLADYNGR LAAEIDDRKQ
LTRMLSDFLR CQKEFLAEKE HKLELLLQVV NMDVSSNDVT IH
//
