ID   A0A3Q0HBP9_ALLSI        Unreviewed;       692 AA.
AC   A0A3Q0HBP9;
DT   13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT   13-FEB-2019, sequence version 1.
DT   27-MAR-2024, entry version 18.
DE   RecName: Full=HECT-type E3 ubiquitin transferase {ECO:0000256|ARBA:ARBA00012485};
DE            EC=2.3.2.26 {ECO:0000256|ARBA:ARBA00012485};
GN   Name=HECTD2 {ECO:0000313|RefSeq:XP_025069027.1};
OS   Alligator sinensis (Chinese alligator).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Crocodylia; Alligatoridae; Alligatorinae;
OC   Alligator.
OX   NCBI_TaxID=38654 {ECO:0000313|Proteomes:UP000189705, ECO:0000313|RefSeq:XP_025069027.1};
RN   [1] {ECO:0000313|RefSeq:XP_025069027.1}
RP   IDENTIFICATION.
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
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DR   RefSeq; XP_025069027.1; XM_025213242.1.
DR   AlphaFoldDB; A0A3Q0HBP9; -.
DR   Proteomes; UP000189705; Unplaced.
DR   GO; GO:0061630; F:ubiquitin protein ligase activity; IEA:InterPro.
DR   GO; GO:0000209; P:protein polyubiquitination; IEA:InterPro.
DR   CDD; cd00078; HECTc; 1.
DR   Gene3D; 3.30.2160.10; Hect, E3 ligase catalytic domain; 1.
DR   Gene3D; 3.30.2410.10; Hect, E3 ligase catalytic domain; 1.
DR   Gene3D; 3.90.1750.10; Hect, E3 ligase catalytic domains; 1.
DR   InterPro; IPR044611; E3A/B/C-like.
DR   InterPro; IPR000569; HECT_dom.
DR   InterPro; IPR035983; Hect_E3_ubiquitin_ligase.
DR   PANTHER; PTHR45700; UBIQUITIN-PROTEIN LIGASE E3C; 1.
DR   PANTHER; PTHR45700:SF2; UBIQUITIN-PROTEIN LIGASE E3C; 1.
DR   Pfam; PF00632; HECT; 1.
DR   SMART; SM00119; HECTc; 1.
DR   SUPFAM; SSF56204; Hect, E3 ligase catalytic domain; 1.
DR   PROSITE; PS50237; HECT; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000189705};
KW   Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786,
KW   ECO:0000256|PROSITE-ProRule:PRU00104}.
FT   DOMAIN          353..692
FT                   /note="HECT"
FT                   /evidence="ECO:0000259|PROSITE:PS50237"
FT   ACT_SITE        660
FT                   /note="Glycyl thioester intermediate"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00104"
SQ   SEQUENCE   692 AA;  79688 MW;  FA3600E90EE5A9C2 CRC64;
     MSETLVRELP PICLDVRQKQ RISIETLPQE LKAPVPPEPS LPVRTKTVKD FQEDMEKAKS
     SGDWKAVLDF YSTTFDSFLE INAAFKNDAN APFDTIEDSG INAKFVNVVY DALLNTPQDV
     QKSVLKGIIN GLLQEWKGPR TKDDLRAYFI LLQNPQFSNT STYVIYAHLL RQTAALAEAD
     HHFLVHWFKK ISQKRFKQLM DRLLQFISLR LFPAKPEEFP PMIKCTWWIP SATKVLSLFN
     AANSLASPPI ISYTDFYNST LDHIDLMEEY HNWQCYGNSH RFSFCQYPFI ISIAAKKVII
     QRDSEQQMIS IARQSLVDKV SRRQKPDMNM LFLNVKVRRT HLVSDSLDEL TRKRADLKKK
     LKVTFVGEAG LDMGGLTKEW FLLLIRQIFH PDYGMFTYHK DSHCHWFSSF KCENYSEFRL
     VGALMGLAVY NSITLDIRFP PCCYKKLLSP PIVPCDQNTP VGICDVTLDD LYQIMPELAH
     GLSELLSYEG NVEEDFYSTF QVFQEEFGAI KSYNLKPNGD KVPVTNRNRK EYVQFYVDFL
     LNKSIYKQFA AFYYGFHSVC ASYALMLLRP EEVEILVCGS PELDMHALQK STQYEGYQKT
     DLTIRYFWEV VLGFPLDLQK KLLHFATGSD RVPVGGMADL NFKISKSETS TNWLPVAHTC
     FNQLCLPPYK NKKELKQKLT IGISNAEGFG LE
//