ID A0A3Q0HCN9_ALLSI Unreviewed; 609 AA.
AC A0A3Q0HCN9;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 19.
DE SubName: Full=Ral guanine nucleotide dissociation stimulator-like 2 isoform X2 {ECO:0000313|RefSeq:XP_025069759.1};
GN Name=RGL2 {ECO:0000313|RefSeq:XP_025069759.1};
OS Alligator sinensis (Chinese alligator).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Crocodylia; Alligatoridae; Alligatorinae;
OC Alligator.
OX NCBI_TaxID=38654 {ECO:0000313|Proteomes:UP000189705, ECO:0000313|RefSeq:XP_025069759.1};
RN [1] {ECO:0000313|RefSeq:XP_025069759.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_025069759.1; XM_025213974.1.
DR AlphaFoldDB; A0A3Q0HCN9; -.
DR Proteomes; UP000189705; Unplaced.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd17211; RA_RGL2; 1.
DR CDD; cd00155; RasGEF; 1.
DR CDD; cd06224; REM; 1.
DR Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 1.
DR InterPro; IPR000159; RA_dom.
DR InterPro; IPR008937; Ras-like_GEF.
DR InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR InterPro; IPR019804; Ras_G-nucl-exch_fac_CS.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR001895; RASGEF_cat_dom.
DR InterPro; IPR036964; RASGEF_cat_dom_sf.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR PANTHER; PTHR23113:SF363; RAL GUANINE NUCLEOTIDE DISSOCIATION STIMULATOR-LIKE 2; 1.
DR Pfam; PF00788; RA; 1.
DR Pfam; PF00617; RasGEF; 1.
DR Pfam; PF00618; RasGEF_N; 1.
DR SMART; SM00314; RA; 1.
DR SMART; SM00147; RasGEF; 1.
DR SMART; SM00229; RasGEFN; 1.
DR SUPFAM; SSF48366; Ras GEF; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 1.
DR PROSITE; PS50200; RA; 1.
DR PROSITE; PS00720; RASGEF; 1.
DR PROSITE; PS50009; RASGEF_CAT; 1.
DR PROSITE; PS50212; RASGEF_NTER; 1.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW ECO:0000256|PROSITE-ProRule:PRU00168};
KW Reference proteome {ECO:0000313|Proteomes:UP000189705}.
FT DOMAIN 67..194
FT /note="N-terminal Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50212"
FT DOMAIN 221..475
FT /note="Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50009"
FT DOMAIN 487..573
FT /note="Ras-associating"
FT /evidence="ECO:0000259|PROSITE:PS50200"
FT REGION 190..211
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 371..395
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 444..485
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 570..593
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 471..485
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 609 AA; 66813 MW; 18FCBE0C8800BE58 CRC64;
MKLFLRLGGC LDPGGQEGPP LSRTRWYCLP AKAPVTLTEA AEDGAIYMVA TRPAPPAAVG
SPGGGQPARS LKAGTLPRLA QHLLEAQTLG DTAYVPAFLA THRAFTRPID VLQLLLDRLE
EVRALEPGPP TPDVTEVQRA FASVLYSWLE GYPEDFRGVL EPGLGERLTR SLQVAAGKGS
ETEQRLQELL GAPAHTEPED EGEDEEEAEE DANPLAFLGF QAEQVAAQLT LLEADLFVRV
VPYECLGSLW SRRGRRGQEG ACPSVRATVR QFNRVAGAVV RSCLGPANLR PLQRARLLEK
WIRVAEECRA LRNFSSLYAI ISALQSSPVH RLKRTWDEIS REAQRSYEEL STICSEQDNY
SLSRQLLFQE GTSKPPGADP IPRRQQRRPQ EQRPMGVVPY LGTFLRDLVM LDAAVKDELE
NGYINFEKRR KHMKWPSVST LDAAPEDAAT SAASPPPAPG GFARTHRRSA SCGSAFPSPQ
SGTSASDCRI IRARMGLSNG SLYKSVLVTS QEKAPAVIAK VLEKHSQDPA TASQYQLVQL
LPEDRELILP PMANVFYAMN STSLDFLLRP KGPPALHPPA PSTPSRRPEL SATFPKIKAT
GRRFPRALF
//
