ID A0A3Q0HCZ6_ALLSI Unreviewed; 5005 AA.
AC A0A3Q0HCZ6;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Ryanodine receptor 2 isoform X11 {ECO:0000313|RefSeq:XP_025069517.1};
GN Name=RYR2 {ECO:0000313|RefSeq:XP_025069517.1};
OS Alligator sinensis (Chinese alligator).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Crocodylia; Alligatoridae; Alligatorinae;
OC Alligator.
OX NCBI_TaxID=38654 {ECO:0000313|Proteomes:UP000189705, ECO:0000313|RefSeq:XP_025069517.1};
RN [1] {ECO:0000313|RefSeq:XP_025069517.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}. Sarcoplasmic
CC reticulum membrane {ECO:0000256|ARBA:ARBA00004326}; Multi-pass membrane
CC protein {ECO:0000256|ARBA:ARBA00004326}.
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DR RefSeq; XP_025069517.1; XM_025213732.1.
DR Proteomes; UP000189705; Unplaced.
DR GO; GO:0033017; C:sarcoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.
DR GO; GO:0005219; F:ryanodine-sensitive calcium-release channel activity; IEA:InterPro.
DR GO; GO:0006874; P:intracellular calcium ion homeostasis; IEA:InterPro.
DR CDD; cd12877; SPRY1_RyR; 1.
DR CDD; cd12878; SPRY2_RyR; 1.
DR CDD; cd12879; SPRY3_RyR; 1.
DR Gene3D; 1.10.287.70; -; 1.
DR Gene3D; 1.10.490.160; -; 2.
DR Gene3D; 2.60.120.920; -; 3.
DR Gene3D; 2.80.10.50; -; 2.
DR Gene3D; 6.20.350.10; -; 1.
DR Gene3D; 1.10.238.10; EF-hand; 1.
DR Gene3D; 1.25.10.30; IP3 receptor type 1 binding core, RIH domain; 1.
DR InterPro; IPR001870; B30.2/SPRY.
DR InterPro; IPR043136; B30.2/SPRY_sf.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR002048; EF_hand_dom.
DR InterPro; IPR014821; Ins145_P3_rcpt.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR036300; MIR_dom_sf.
DR InterPro; IPR016093; MIR_motif.
DR InterPro; IPR013662; RIH_assoc-dom.
DR InterPro; IPR000699; RIH_dom.
DR InterPro; IPR013333; Ryan_recept.
DR InterPro; IPR015925; Ryanodine_IP3_receptor.
DR InterPro; IPR003032; Ryanodine_rcpt.
DR InterPro; IPR009460; Ryanrecept_TM4-6.
DR InterPro; IPR048581; RYDR_Jsol.
DR InterPro; IPR035910; RyR/IP3R_RIH_dom_sf.
DR InterPro; IPR035761; SPRY1_RyR.
DR InterPro; IPR035764; SPRY2_RyR.
DR InterPro; IPR035762; SPRY3_RyR.
DR InterPro; IPR003877; SPRY_dom.
DR PANTHER; PTHR46399; B30.2/SPRY DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR46399:SF7; RYANODINE RECEPTOR 2; 1.
DR Pfam; PF13499; EF-hand_7; 1.
DR Pfam; PF08709; Ins145_P3_rec; 1.
DR Pfam; PF00520; Ion_trans; 1.
DR Pfam; PF02815; MIR; 1.
DR Pfam; PF08454; RIH_assoc; 1.
DR Pfam; PF06459; RR_TM4-6; 1.
DR Pfam; PF01365; RYDR_ITPR; 2.
DR Pfam; PF21119; RYDR_Jsol; 1.
DR Pfam; PF02026; RyR; 5.
DR Pfam; PF00622; SPRY; 3.
DR PRINTS; PR00795; RYANODINER.
DR SMART; SM00472; MIR; 4.
DR SMART; SM00449; SPRY; 3.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 2.
DR SUPFAM; SSF47473; EF-hand; 1.
DR SUPFAM; SSF100909; IP3 receptor type 1 binding core, domain 2; 1.
DR SUPFAM; SSF82109; MIR domain; 2.
DR PROSITE; PS50188; B302_SPRY; 3.
DR PROSITE; PS50222; EF_HAND_2; 1.
DR PROSITE; PS50919; MIR; 4.
PE 4: Predicted;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Calcium channel {ECO:0000256|ARBA:ARBA00022673};
KW Calcium transport {ECO:0000256|ARBA:ARBA00022568};
KW Calmodulin-binding {ECO:0000256|ARBA:ARBA00022860};
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Ligand-gated ion channel {ECO:0000256|ARBA:ARBA00023286};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000313|RefSeq:XP_025069517.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000189705};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Sarcoplasmic reticulum {ECO:0000256|ARBA:ARBA00022951};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 4316..4334
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 4538..4558
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 4612..4631
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 4748..4769
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 4806..4827
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 4882..4905
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 114..169
FT /note="MIR"
FT /evidence="ECO:0000259|PROSITE:PS50919"
FT DOMAIN 229..284
FT /note="MIR"
FT /evidence="ECO:0000259|PROSITE:PS50919"
FT DOMAIN 290..347
FT /note="MIR"
FT /evidence="ECO:0000259|PROSITE:PS50919"
FT DOMAIN 355..412
FT /note="MIR"
FT /evidence="ECO:0000259|PROSITE:PS50919"
FT DOMAIN 615..813
FT /note="B30.2/SPRY"
FT /evidence="ECO:0000259|PROSITE:PS50188"
FT DOMAIN 1061..1258
FT /note="B30.2/SPRY"
FT /evidence="ECO:0000259|PROSITE:PS50188"
FT DOMAIN 1393..1598
FT /note="B30.2/SPRY"
FT /evidence="ECO:0000259|PROSITE:PS50188"
FT DOMAIN 4059..4094
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT REGION 1892..1923
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4372..4396
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4456..4506
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4376..4394
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 5005 AA; 569750 MW; 4F27C7AE6307D603 CRC64;
MRPIEDQQTM LQLGHVFPCE DDEVVLQCTA TVHKEQQKLC LAAEGFGNRL CFLESTSNSK
NVPPDLSICT FVLEQSLSVR ALQEMLANTE EKAEGLVDVE KWKFMMKTAQ GGGHRTLLYG
HAILLRHSYS GMYLCCLSTS RSSMDKLAFD VGLQEDTTGE ACWWTIHPAS KQRSEGEKVR
VGDDLILVSI SSERYLHLSY GNGSLHVDAA FQQTLWSVAP ISSGSEVAQG YLIGGDVLRL
LHGHMDECLT VPSGEHGEEL RRTVHYEGGA VSIHARSLWR LETLRVAWSG SHIRWGQPFR
LRHITTGKYL SLLDDKSLLL TDKEQADVKS TAFCFRSSKE KLDVGIRKEV DGMGAPEIKY
GDSVCYIQHI DTGLWLTYQS VDAKSVRMGS VQRKAIMHHE GHMDDGLTLS RSQHEESRTA
RVIRSTVFLF NRFIRGLDAL SKKAKSSTVD LPIESVSLSL QDLIGYFHPP DEHLEHEDKQ
NRLRALKNRQ NLFQEEGMIN LVLECIDRLH VYSSAAHFAD VAGKEAGETW KSILNSLYEL
LAALIRGNRK NCAQFSGSLD WLISRLERLE ASSGILEVLH CVLVESPEAL NIIKEGHIKS
IICLLDKHGR NHKVLDVLCS LCVCHGVAVR SNQHLICDNL LPGRDLLLQT RLVNHVSSMR
PNIFLGISEG SAQYRKWYYE LMVDHVEPFV TAEATHLRVG WASTEGYSPY PGGGTEWGGN
GVGDDLYSYG FDGLHLWSGC VARTVNSPNQ HLLKTDDVVS CCLDLSAPSI SFRINGQPVQ
GMFENFNIDG LFFPVVSFSA GIKVRFLLGG RHGEFKFLPP PGYAPCFEAV LPKEKLKVEQ
SREYKQDRNG TRDLLGPTIS LSQAAFTPIP VDTSQIVLPP HLERIREKLA ENIHELWVMN
KIELGWQYGP VRDDNKRQHP CLVEFSKLPE QERNYNLQMS LETLKTLLAL GCHVGITDEH
AEEKVKKVKL PKNYQLSSGY KPTPMDLSFI KLTPSQEAMV DKLAENAHNV WARDRIRQGW
TYGIQQSQPA SQQREHKLTN KPCSQNCADI NDDTDHKQDV KNRRNPRLVP YALLDDRTKK
SNKDSLREAV RTLLGYGYNL EAPDQDHATR SDVCSGIMEK FRIFRTEKTY AVKAGKWYFE
FEAVTAGDMR VGWTRPGCLP DQELGADEQA FVFDGFKAQR WHQGNEHFGR SWLAGDVVGC
MVDMNEHTMM FTLNGEILLD DSGSELAFKD FEVGDGFIPV CSLGSSQVGR MNFGKDVSTL
KYFTICGLQE GYEPFAVNTN RDITMWLSKR LPQFLPVPPN HEHIEVMRID GTIDSCLCLK
VTQKSFGSQN SKTDVMFFRL SMPIECAEVF SKTPAGGLPG SGLFGPKNDL EDYDADSDFE
VLMKTAHGHL VPDRVEREKE AAKPEFNNHK DYTQEKPSRL KQRFMLRRTK PDYSTSHSAR
LTEDVLADDR DDYDYLMQTS TYYYSVRIFP GQEPANVWVG WITSDFHQYD TTFDLDRVRT
VTVTLGDEKG KVHESIKRSN CYMVCAGESM SPGQGRNNNG LEIGCLVDAA SGLVTFTANG
KELSTYYQVE PSTKLFPAVF AQATSPNVFQ FELGRIKNVM PLSAGLFKSE HKNPVPQCPP
RLHVQFLTHV LWSRVPNHFL KVDVSRVSER QGWMIQCLDP LQFMALHVPE ENRSIDILEL
TEQEELLKFH YHALRLYSAV CALGNNRVAH AMCSHVDESQ LLYAIENKYM PGLLRTGYYD
LLIDIHLNTY ATARLMMNNE FIVPMTDETK SITLFPDENK KHGLPGIGLS TSLRPRMQFS
SPSFVSISSE CYQFSPEFPL EILKAKTIEM LTEAVQEGSL HVRDPVGGST EFLFVPLIKL
FYTLLIMGVF HNGDLKHILQ LIEPSVFKED ISKEDENEMP EKELTTEELK PEGGEEEARG
EQVPKEGLLQ MKLPEPVKLQ MCHLLQYLCD CQIRHRIEAI VAFSDDFVAK LQENQRFRYN
EVMQALNMSA ALTARKTKEF RSPPQEQINM LLNFKDDKSD CPCPEEIRDQ LLDFHEDLMT
HCGIELDEDG ALDGSSDLTI RGRLLYLVEK MTYLKKKQTE KPTDNHSKKP STLQQLISDT
MVRWAQESVI EDPELVRAMF VLLHRQYDGI GGLVRTLPKT YTINSVSVED TINLLASLGQ
IRSLLSVRMG KEEEKLMIHG LGDIMNNKVF YQHPNLMRAL GMHETVMEVM VNVLGGGESK
EITFPKMVAN CCRFLCYFCR ISRQNQKAMF DHLSYLLENS SVGLASPSMR GSTPLDVAAA
SVMDNNELAL ALREPDLEKV VRYLAGCGLQ SCPLLISKGY PDIGWNPVEG ERYLDFLRFA
VFCNGESVEE NANVVVRLLI RRPECFGPAL RGEGGNGLLA AMEEAIKISE DPTRDGPSPS
NGSCKTLEME EQEDDTIHMG NAIMTFYAAL IDLLGRCAPE MHLIHAGKGE AIRIRSILRS
LIPLEDLVGV ISIPFHMPTI AKDGTVVEPD MSAGFCPDHK AAMVLFLDRV YGIEDQDFLL
HLLEVGFLPD LRAAASLDTA ALSATDMALA LNRYLCTAVL PLLTRCAPLF AGTEHHASLI
DSLLHTVYRL SKGCSLTKAQ RDSIEECLLS ICGQLRPSMM QHLLRRLVFD VPLLNEHAKM
PLKLLTNHYE RCWKYYCLPG GWGNFGAASE EELHLSRKLF WGIFDALSQK KYEQELFKLA
LPCLSAVAGA LPPDYMESNY VSMMEKQSSM DSDGNFNPQP VDTSNITIPE KLEYFINKYA
EHSHDKWSME KFANGWIYGE MYSESAKVQP LMKQYKLLSE KEKEIYRWPI KESLKTMLAW
GWRIERTREG DTMALYNRTR RISQTSQVSV DTAHGYSPRA IDMSNVTLSR DLHAMAEMMA
ENYHNIWAKK KKMELEAKVG GGNHPLLVPY DTLTAKEKAK DREKAQDILK FLQINGYVVS
RGLKDLELDT PSIEKRFAYS FLQQLIRYVD EAHQYILEFD GGSRGKGEHF PYEQEIKFFA
KVVLPLIDQY FKNHRLYFLS AASRPLSSGG HASNKEKEMV TSLFCKLGVL VRHRISLFGN
DATSIVNCLH ILGQTLDART VMKTGLESVK MALRAFLDNA AEDLEKTMEN LKQGQFTHTR
NQPKGVTQII NYTTVALLPV LSSLFEHIGQ HQFGEDLILE DVQISCYRIL ASLYALGTSK
SIYVERQRSA LGECLAAFAG AFPVAFLETH LNKHNTYSIY NTKCARDRAA LDLPMSVDEV
CPNIPSLEKL MEEIVELAES GIRYTQMPHI MEVILPMLCS YMSHWWEHGP ENNPEKAEMC
CTGLTSEHMN TLLGNILKII YNNLGIDEGA WMKRLAVFSQ PIISKAKPQL LKTHFLPLMD
KLKKKAAMVI TDEEHLRAEG RGDMSEAELL ILDEFTTLAR DLYAFYPLLI RFVDYNRAKW
LKEPNPEAEE LFRMVADVFI YWSKSHNFKR EEQNFVVQNE INNMSFLITD TKSKMSKAAV
SDQERKKMKR KGDRYSTQTS LIVAALKRLL PIGLNICAPG DQELIALAKT RFSMKDTEDE
VRDIIRSNLH LQGKLEDPAI RWQMALYKDL PNRTENTSDP DKTVERVLDI ANVLFHLEQI
SSKMVRRFFP WVEHPQRSKK AVWHKLLSKQ RKRAVVACFR MAPLYNLPRH RAVNLFLQGY
EKSWIETEEH YFEDKLIEDL ARPGEEPPEE EESIKRVDPL HQLILLFSRT ALTEKCKLEE
DFLYMAYADI MAKSCHDEED DDGEEEVKSF EEKEMEKQKL LYQQARLHDR GAAEMVLQTI
SASKGEMGPM VAATLKLGIA ILNGGNSTVQ QKMLDYLKDK KDVGFFQSLA GLMQFCSVLD
LNAFERQNKA EGLGMVTEEG SGEKVMQDDE FTCDLFRFLQ LLCEGHNSDF QNYLRTQTGN
NTTVNIIIST VDYLLRVQES ISDFYWYYSG KDVIDEQGQR NFSKAIQVAK QVFNTLTEYI
QGPCTGNQQS LAHSRLWDAV VGFLHVFAHM QMKLSQDSSQ IELLKELMDL QKDMVVMLLS
MLEGNVVNGT IGKQMVDMLV ESSNNVEMIL KFFDMFLKLK DLTSSDAFKE YDPDGKGVIS
KRDFQKAMES HKHYTQSETE FLLSCAEPDE NETLDYEEFV KRFHEPAKDI GFNVAVLLTN
LSEHMPHDTR LQTFLELAES VLNYFQPFLG RIEIMGSAKR IERVYFEISE SSRTQWEKPQ
VKESKRQFIF DVVNEGGEKE KMELFVNFCE DTIFEMQLAA QISESDLSER SANKEESEKD
KLEEQDPRMG FFTLVTVKSA LVALKYNIMT LMKMLSVKSL KKQMKKMKKM TMKDMVMAFF
SSYWSILMGL LHFTSSVFRG FFRIMYSLLL GGSLVEGAKK IKVAELLANM PDPTQDEVRG
EGEEGERKPT ETALPAEDLT DLTALSDDGD LLSDIFGLDL KREGGQYKLI PHNPNAGLSD
LLSTPSLLPL PEVQEKVQEQ KVKEDEKDEK EETKSEPEKA EGEDGEKEEK TKDEKGKQKL
RQLHTHRYGE PEVQESAFWK KIIAYQQKLL NYFARNFYNM RMLALFVAFA INFILLFYKV
STSSATEEKE VHVVHAGENS KLNSLESGSH RIITVHYVLE ESSGYMEPTL RILAILHTVI
SFFCIIGYYC LKVPLVIFKR EKEVARKLEF DGLYITEQPS EDDIKGQWDR LVINTQSFPN
NYWDKFVKRK VMDKYGEFYG RDRISELLGM DKAALDFSDA REKKKPKKDS SLSAVLNSID
VKYQMWKLGV VFTDNSFLYL AWYMTMSVLG HYNNFFFAAH LLDIAMGFKT LRTILSSVTH
NGKQLVLTVG LLAVVVYLYT VVAFNFFRKF YNKSEDGDMP DMKCDDMLTC YMFHMYVGVR
AGGGIGDEIE DPAGDEYEIY RIIFDITFFF FVIVILLAII QGLIIDAFGE LRDQQEQVKE
DMETKCFICG IGNDYFDTVP HGFETHTLQE HNLANYLFFL MYLINKDETE HTGQESYVWK
MYQERCWEFF PAGDCFRKQY EDQLN
//
