ID A0A3Q0HEJ5_ALLSI Unreviewed; 5202 AA.
AC A0A3Q0HEJ5;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE SubName: Full=E3 ubiquitin-protein ligase UBR4 isoform X2 {ECO:0000313|RefSeq:XP_025068908.1};
GN Name=UBR4 {ECO:0000313|RefSeq:XP_025068908.1};
OS Alligator sinensis (Chinese alligator).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Crocodylia; Alligatoridae; Alligatorinae;
OC Alligator.
OX NCBI_TaxID=38654 {ECO:0000313|Proteomes:UP000189705, ECO:0000313|RefSeq:XP_025068908.1};
RN [1] {ECO:0000313|RefSeq:XP_025068908.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the UBR4 family.
CC {ECO:0000256|ARBA:ARBA00009970}.
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DR RefSeq; XP_025068908.1; XM_025213123.1.
DR Proteomes; UP000189705; Unplaced.
DR GO; GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR CDD; cd19680; UBR-box_UBR4; 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR025704; E3_Ub_ligase_UBR4_C.
DR InterPro; IPR045841; E3_UBR4_N.
DR InterPro; IPR045189; UBR4-like.
DR InterPro; IPR047509; UBR4-like_UBR-box.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR003126; Znf_UBR.
DR PANTHER; PTHR21725; E3 UBIQUITIN-PROTEIN LIGASE UBR4; 1.
DR PANTHER; PTHR21725:SF1; E3 UBIQUITIN-PROTEIN LIGASE UBR4; 1.
DR Pfam; PF13764; E3_UbLigase_R4; 1.
DR Pfam; PF19423; E3_UBR4_N; 1.
DR Pfam; PF02207; zf-UBR; 1.
DR SMART; SM00396; ZnF_UBR1; 1.
DR SUPFAM; SSF48371; ARM repeat; 2.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS51157; ZF_UBR; 1.
PE 3: Inferred from homology;
KW Calmodulin-binding {ECO:0000256|ARBA:ARBA00022860};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000189705};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT DOMAIN 1640..1713
FT /note="UBR-type"
FT /evidence="ECO:0000259|PROSITE:PS51157"
FT ZN_FING 1640..1713
FT /note="UBR-type"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00508"
FT REGION 194..213
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 534..573
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 585..623
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1717..1770
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2434..2461
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2705..2731
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2749..2785
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2854..2988
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3360..3405
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 534..556
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 557..571
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 589..606
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 607..622
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1755..1770
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2709..2731
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2854..2912
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2949..2971
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3360..3384
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3385..3404
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 5202 AA; 576757 MW; 6683495F552CB5EB CRC64;
MAASGGVGAA EPGWEVAVRP LLSASYSAFE LKELPQLLAS VIESESEILH HDKQYEPFYS
SFVALSTHYI TTVCGLIPRN QLQSVAAACK VLIEFSLLRL ENPDEACAVS QKHLILLIKG
LCTGCSRLDR TEIITFTAMM KSAKLPQTVK TLSDVEDQKE LASPVSPELR QKEVQMNFLN
QLTSVFNPRV TASPSLAPET QVEGESEDQT STDQASAAKT KSIFIAQNVA SLQELGGSEK
LLRVCLNLPY FLRYINRFQD AVSANSFFIM PATVADATAV RNGFHSLVID VTMALDTLSL
PVLEPLTPTR LQDVTVLALS CLYAGVSVAT CMAILHVGST QQVRTGSTSS KEEDYENDAA
TIVQKCLEIY EMIGQAISNS RRAGGEHYQN FQLLGAWCLL NSLFLILNLS PTALADKGKE
KDPLAALRVR DIIARTKEGV GSPKLGPGKG HQGFGVLSVV LANHAIKLLT SLFQDLQVEA
LHKGWETDGP PAVLNIMAQS TSIQRIQRLI DSVPLTNLLL TLLSTSYRKA CVLQRQRKGS
MSSDASASTD SNTYYEDDFS STEEDSSQDD DSEPILGQWF EETISPRKGK VAPPPPPPPP
PLESSPRVKS PNKQTTGENG NILASRKDPE LFLSLASNIL NFITSSMLNS RNNFIRNYLS
VSLSEQHMAT LASIIKEVDK DGLKGTSDEE FAAALYHFNH SLVTSDLQSP TLQNTLLQQL
GVAPFSEGPW PLYIHPQSLS VLSRLLLIWQ HKASAQGDPD VPECLRVWER FVSTLKQNAL
QGALPNDTED LNVEHLQLLL LIFHNFSEKG RRSILTLCIQ TILDLTVKMD SQLQSVPLIL
ARLLLVFDYL LHQYSKVPMY LFEQVQYNLL TPPIGWVSGS QESSRRTAIP IYHGFKEVEE
NWTKHCSSDA VPQPRFYCIL SPEASEDDLN RLDNMVCEVL FSRIVKYDEL YAALTSLLAA
GSQFDTLRRK ENKNVTALEA CALQYYFLIL WRILGILPPS KNYMNQLAMN TPDMSECDIL
HTLRWSSRLR IISYVVWIKD HLIKQGMKAE HAASLIKLAS TKCSSVKYDV EIAEEYFARQ
ISSFCGIDCT TILQLHEIPS LQSIYTLDAA ISKIQVSLDE HFSKLAAETD PHKSSEITKN
LLPATLQLID TYATFTRSYL LRSLSEEGSA ENKPSEEKLR GYAAVLAIGS SRCKSNTLGP
TLVQNLPPAV QTLCESWNNI HTNEFPNIGS WRNAFANDTI PAESYISAVQ AAHLGTLCSQ
SLPLAASLKH TLLSLVRLTG DLIVWSDELN PQQVIHTLLP LLLETSTESV AEISSNSLER
VLGPAESDEF LARVYEKLIT GCYNILANHS DPNSGLDESI LEECLQHLEK QLESSQARKA
MEEFFSESGE LVQIMMATAN ENLSAKFCNR VLKFFTKLFQ LTEKSPNPSL LRLCGSLAQL
ACVEPVRLQA WLTRMTMSPP KDSDQLDVVQ ENRQLLQLLT TYIVRENSQV GEGVCTVLLS
TLIPMATEML ANGDGTGFPE LMVVMATLAS AGQGAGHLQL HSAAVDWLSR CKKYLSQKNV
IEKMNANVMQ GKHVTILECT CHIVSYLADV TNALSQTSGQ GPSHLSVDGE ERAIEVDSDW
VEELAVEEED SQAEDSDEDS LCNKLCTFTI TQKEFMNQHW YHCHTCKMVD GVGVCTVCAK
VCHKDHEISY AKYGSFFCDC GAKEDGSCLA LVKRTPSSGM SSTMKESAFQ SEPRVPESVI
RHATTSPAEK SKVTISEGKG PDEEKPKKSS LCRNVEGCRE ELQSQANFSF APLVLEMLNF
LMEAIQINFQ QASAMGSSSR AQQALNELHA VDKTVEMTDQ LMVPTLGSQE GAFENVRMNY
SGDQGQTIRQ LISAHVLRRV AMCVLSSPHG RRQHLAVSHE KGKITVLQLS ALLKQADSSK
RKLTLTRLAS APVPFTVLSL TGNPCKEDYL AVCGLKDCHV LTFSSSGSVS DHLVLHPQLA
TGNFIIKAVW LPGSQTELAI VTADFVKIYD LSVDALSPTF YFLLPSSKIR DVTFLFNEEG
KNIIVIMSSA GYIYTQLMEE ASSAQHGPFY VTNVLEVSHE DLKDSNGQVA GGGVSVYYSH
VLQMLFFSYC QGKSFAATIS RATLEVQRLF PINIKSSNGG SKTSPALCQW SEVMNHPGLV
CCVQQTTGVP LVVMVKPDTF LIQEIKTLPA KAKIQDMVAI RHTACNEQQR TTMILLCEDG
SLRIYMANVE NTSYWLQPSL QPSSVISIMK PVRKRKAAAI TTRTSSQVNF PIDFFEHNQQ
LTDVEFGGND LLQVYNAQQI KHRLNSTGMY VANTKPGGFT IEVTNNNSTM VMTGMRIQIG
TQAIERAPSY LEIFGRTMQL NMTRARWFDF PFTREEALQA DKKLTIFIGA SVDPAGVTMM
DSIKIYGKTK EQFGWPDEPP EDFPSASVSN VCPPNLNQGN GTGDTEAATP ATASGTVLES
SETESLTTLD RLVVSSLEAL ESCFAVGPVN EKEKNKAAAQ ELATMLLSMP APSSVQQQTK
SLLASLHTSR SAYHNHKDQA LLSKAIQYLS SSSKEGKDLD PEVFQRLVIT ARSIAIMRPN
NLVHFTESKL PQLEAAGEEG QEAQKHAEGD GCSFITQLVN HFWKLHASKP KNAFLAPACL
PGLTHVEATV NALVDIIHGY CTCELDCINT ASKIYMQMLL CPDPAVSFSC KQALIRVLRP
RNKRRHVTLP SSPRSNTPME QEWNLDSSPG SPTRRNGYVC EWYLCGPGDK DDDDDDDAED
KMQTSGIANG EHIRQESQEQ SEVDHGDFEM VSESMVLETS ENVNNGNPSP LEALLAGAEG
FPPMLDIPPD ADDETMVELA IALSLQQDQQ GSSSSALGLQ SLGLSGQAPS SSSLDAGTLS
DTTASAPASD DEGSTAATDG STLRTSPADH GGSVGSESGG SAVDSVAGEH SVSGRSSAYG
DTTAEGHPAG PGSVSSSTGA ISTTTGQQEG DGSEGEGEGE AEGDVHTSNR LHMVRLMLLE
RLLQNLPQLR NVGGVRAIPY MQVILMLTTD LDGDDEKDKG ALDNLLSQLI AELCMDKKDV
SKKNERSPVN EVHLVVMRLL SVFMSRTKSG SKSSICESSS LISSATAAAL LSSGAVDYCL
HVLKSLLEYW KSQQNDEEPV ATSQLLKPHT TSSPPDMSPF FLRQYVKGHA ADVFEAYTQL
LTEMVLRLPY QIKKIADTNS RIPPPIFDHS WFYFLSEYLM IQQTPFVRRQ VRKLLLFICG
SKEKYRQLRD LHTLDSHVRG IKKLLEEQGI YLRASVVTAS SGSALQYDTL ISLMEHLKAC
AEIATQRTVN WQKFCIKDDS VLYFLLQVSF LVDEGVSPVL LQLLSCALCG SKVLSVASSS
GSSTSSTSAP AASGSGQPAT QSKSSTKKSK KEEKEKEREG ESSGSQEDQL CTALVNQLNK
FADKETLIQF LRCFLLESNS SSVRWQAHCL ALHIYRNSNK SQQELLLDLM WSVWPELPAY
GRKAAQFVDL LGYFSLKTQQ TEKKLKEYSQ KAVEILRTQN HILTNHPNSN IYNTLSGLVE
FDGYYLESDP CLVCNNPEVP FCYIKLSSIK VDTRYTTTQQ VVKLIGSHTI SKVTVKIGDL
KRTKMVRTIN LYYNNRTVQA IVELKNKPAR WHKAKKVQLT PGQTEVKIDL PLPIVASNLM
IEFADFYENY QASTETLQCP RCSASVPANP GVCGNCGENV YQCHKCRSIN YDEKDPFLCN
ACGFCKYARF DFMLYAKPCC AVDPIENEED RKKAVTNINT LLDKADRVYH QLMGHRPQLE
NLLCKVNEAA PEKPQDESGS SGGISSTSAS VNRYILQLAQ EYCGDCKNSF EELSKIIQKV
FASRKELLEY DLQQREAATK SSRTTVQPTF TASQYRALSV LGCGHTSSTK CYGCASAVTE
HCITLLRALA TNSAIRHILV SQGLIRELFD YNLRRGAATM REEVRQLMCL LTRDNPEATQ
QMNDLIIGKV SAALKGHWAN PDLASSLQYE MLLLTDSISK EDSCWELRLR CALSLFLMAV
NIKTPVVVEN ITLMCLRILQ KLIKPPAPTS KKNKDVPVNT LTTVKPYSNE IHAQAQLWLK
RDPKASYEAW KKCLPARGIE ANGKSPSRTE LHQLYLSEKY IWKWKQFMSR RGKRTCPLDL
KLGHNNWLRQ VLFTPATQAA RQAACTIVEA LATIPSRKQQ VLDLLTSYLD ELSIAGECAA
EYLGLYQKLI KPAHWKVYLA ARGVLPYIGN LITKEIARLL ALEEATLSTD LQQGYALKSL
TGLLSSFVEV ESIKRHFKSR LVGTVLNGYL CLRKLVVQRT KLIDETQDML LEMLEDMTTG
TESETKAFMA VCIETAKRYS LDDYRTPVFI FERLCSIIYP EENEVTEFFV TLEKDPQQED
FLQGRMPGNP YSSNEPGIGP LMRDIKNKIC QDCDLVALLE DDSGMELLVN NKIISLDLPV
AEVYKKVWCP TNEGEPMRII YRMRGLLGDA TEEFIESLDS TTDEEEDEEE VYKMAGVMAQ
CGGLDCMLNR LTGIKDFKQG RHLLTVLLKL FSYCVKVKVN RQQLVKPEMN TLNVMLGTLN
LALVAEQESK DSGGAAVAEQ VLSIMEIILD ESNAEPLSED KGNLLLTGDK DQLVMLLDQI
NSTFVRSNLS VLQGLLRIIP YLSFGEMEKM QILVDRFKPY CNFDKYDEEH SGDDKVFLDC
FCKIAAGIKN NSNGHQLKDL ILQKGITQNA LDYMKKHIPS AKNLDADIWK KFLSRPALPF
ILRLLRGLAT QHPATQALIG TDSITNLHKL EQVSSDEGIG TLAENLLEAL REHPEVNKKI
DAARKETRAE KKRMAMAMRQ KALGTLGMTT NEKGQVVTKT ALLKQMEELI EEPGLTCCIC
REGYKFQPAK VLGIYTFTKR VALEEFENKP RKQQGYSTVS HFNIVHYDCH LAAVRLARGR
EEWESAALQN ANTKCNGLLP VWGPHVPESA FATCLARHNT YLQECTGQRE PTYQLNVHDI
KLLFLRFAME QSFSVDTGGG GRESNIHLIP YIIHTVLYVL NTTRATSREE KNLQSFMEHP
KEKWVESAYE VDGPHYYTVL ALHILPPEKW KAMRVEILKR LLVTSHARAV SPGGASRLTD
KTVKEYSTYR SGLLFWALVD LIYNMFKKVP TSNTEGGWSY SLAEFIRHND MPIHEAADKA
LKTFQEEFMP VETFSEFLDV AGLLTEISDP DSFLKDLLNS IP
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