ID A0A3Q0HF46_ALLSI Unreviewed; 849 AA.
AC A0A3Q0HF46;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE RecName: Full=Transient receptor potential cation channel subfamily V member 1 {ECO:0000256|ARBA:ARBA00015942};
DE AltName: Full=Osm-9-like TRP channel 1 {ECO:0000256|ARBA:ARBA00033256};
DE AltName: Full=Vanilloid receptor 1 {ECO:0000256|ARBA:ARBA00031766};
GN Name=LOC102372182 {ECO:0000313|RefSeq:XP_025070601.1,
GN ECO:0000313|RefSeq:XP_025070602.1, ECO:0000313|RefSeq:XP_025070603.1,
GN ECO:0000313|RefSeq:XP_025070604.1};
OS Alligator sinensis (Chinese alligator).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Crocodylia; Alligatoridae; Alligatorinae;
OC Alligator.
OX NCBI_TaxID=38654 {ECO:0000313|Proteomes:UP000189705, ECO:0000313|RefSeq:XP_025070601.1};
RN [1] {ECO:0000313|RefSeq:XP_025070601.1, ECO:0000313|RefSeq:XP_025070602.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Cell
CC projection, dendritic spine membrane {ECO:0000256|ARBA:ARBA00004332};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004332}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}. Postsynaptic cell membrane
CC {ECO:0000256|ARBA:ARBA00034104}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00034104}. Synaptic cell membrane
CC {ECO:0000256|ARBA:ARBA00034099}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00034099}.
CC -!- SIMILARITY: Belongs to the transient receptor (TC 1.A.4) family. TrpV
CC subfamily. TRPV1 sub-subfamily. {ECO:0000256|ARBA:ARBA00010374}.
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DR RefSeq; XP_025070601.1; XM_025214816.1.
DR RefSeq; XP_025070602.1; XM_025214817.1.
DR RefSeq; XP_025070603.1; XM_025214818.1.
DR RefSeq; XP_025070604.1; XM_025214819.1.
DR STRING; 38654.A0A3Q0HF46; -.
DR OrthoDB; 1003028at2759; -.
DR Proteomes; UP000189705; Unplaced.
DR GO; GO:0032591; C:dendritic spine membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0045211; C:postsynaptic membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0005216; F:monoatomic ion channel activity; IEA:InterPro.
DR CDD; cd22196; TRPV1; 1.
DR Gene3D; 1.10.287.70; -; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR024862; TRPV.
DR InterPro; IPR008347; TrpV1-4.
DR NCBIfam; TIGR00870; trp; 1.
DR PANTHER; PTHR10582:SF17; TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL SUBFAMILY V MEMBER 1; 1.
DR PANTHER; PTHR10582; TRANSIENT RECEPTOR POTENTIAL ION CHANNEL PROTEIN; 1.
DR Pfam; PF00023; Ank; 1.
DR Pfam; PF00520; Ion_trans; 1.
DR PRINTS; PR01768; TRPVRECEPTOR.
DR SMART; SM00248; ANK; 4.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 1.
DR PROSITE; PS50088; ANK_REPEAT; 1.
PE 3: Inferred from homology;
KW ANK repeat {ECO:0000256|PROSITE-ProRule:PRU00023};
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Calmodulin-binding {ECO:0000256|ARBA:ARBA00022860};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Receptor {ECO:0000313|RefSeq:XP_025070601.1,
KW ECO:0000313|RefSeq:XP_025070602.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000189705};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 444..466
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 486..504
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 525..545
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 551..570
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 591..613
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 671..694
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REPEAT 212..244
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT DOMAIN 507..706
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT REGION 1..59
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 32..52
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 849 AA; 97125 MW; 4BE79B5987472EEB CRC64;
MSSILGMMKK FGSSDVEESE VTDEHTDGED STLGTPDSLQ GTQSTKLQPP PKSNIFSRRG
RFVMGDSDKD MAPMDSFYPM DHLMSPPIIK FSANLERGKF HHHFGKLLST ESITSCSDKA
FKYYDRRRIF DAVAQGDVSD LDHLPMYLSR TLKHLTDDEF KEPETGKTCL LKAMLNLHEG
KNNAIPLLLD IAEKTGNLKE FVNAGYTDNY YKGQTALHIA IERRNMYLVK LLVRNGADVH
ARAHGEFFRK IKGKPGFYFG ELPLSLAACT NQLCIVKFLL ENSYQPANIV AEDSMGNTVL
HALVEVADNT KDNTKFVTKM YNNILILGAK INPMLKLEEL ANKKGLTPLT LAAKTGKIGI
FAYILRREIK DPECRHLSRK FTEWAYGPVH SSLYDLSSVD TCERNSVLEI IAYSSETPNR
HEMLLVEPLN RLLQDKWDRF VKHLFYFNFC VYAIHIIILT IAAYYRPVKK EREQPPFAFG
YSTGEYFRVT GEILSVLGGL YFFSRGIQYF VQRRPSFRTL LADSYSEVLF FVHSLLLLSS
LVLYFSGQEL YVASMVFSLA LGWANMLYYT RGFQQMGIYS VMIEKMILRD LCRFMFVYLV
FLLGFSTAVV TLIEDDNEGQ DNSTADCPRC CQLKRSRTSY NNLYYTCLEL FKFTIGMGDL
EFTENYRFKS VFVILLVLYV ILTYILLLNM LIALMGETVN KIAQESKSIW KLQRAITILD
IENSYLNCVR RSFRSGKRVL VGTTPDGKDD YRWCFRVDEV NWSTWNTNLG IINEDPGYYG
DLKRNSSFSF KAGRVSGKNW KTLVPLLRDG SRREEAPKLT EEVKFKSVLE PCYESDNFKA
PTDSIPKSA
//
