ID A0A3Q0HHL6_ALLSI Unreviewed; 849 AA.
AC A0A3Q0HHL6;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=Nuclear factor NF-kappa-B p105 subunit isoform X9 {ECO:0000313|RefSeq:XP_025071446.1};
GN Name=NFKB1 {ECO:0000313|RefSeq:XP_025071446.1};
OS Alligator sinensis (Chinese alligator).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Crocodylia; Alligatoridae; Alligatorinae;
OC Alligator.
OX NCBI_TaxID=38654 {ECO:0000313|Proteomes:UP000189705, ECO:0000313|RefSeq:XP_025071446.1};
RN [1] {ECO:0000313|RefSeq:XP_025071446.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR RefSeq; XP_025071446.1; XM_025215661.1.
DR AlphaFoldDB; A0A3Q0HHL6; -.
DR Proteomes; UP000189705; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd08797; Death_NFkB1_p105; 1.
DR CDD; cd01177; IPT_NFkappaB; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR Gene3D; 1.10.533.10; Death Domain, Fas; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR Gene3D; 2.60.40.340; Rel homology domain (RHD), DNA-binding domain; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR011029; DEATH-like_dom_sf.
DR InterPro; IPR000488; Death_domain.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR014756; Ig_E-set.
DR InterPro; IPR002909; IPT_dom.
DR InterPro; IPR033926; IPT_NFkappaB.
DR InterPro; IPR047096; NF-kB_p105_DD.
DR InterPro; IPR000451; NFkB/Dor.
DR InterPro; IPR008967; p53-like_TF_DNA-bd_sf.
DR InterPro; IPR032397; RHD_dimer.
DR InterPro; IPR011539; RHD_DNA_bind_dom.
DR InterPro; IPR037059; RHD_DNA_bind_dom_sf.
DR PANTHER; PTHR24169:SF9; NUCLEAR FACTOR NF-KAPPA-B P105 SUBUNIT; 1.
DR PANTHER; PTHR24169; NUCLEAR FACTOR NF-KAPPA-B PROTEIN; 1.
DR Pfam; PF00023; Ank; 1.
DR Pfam; PF12796; Ank_2; 2.
DR Pfam; PF00531; Death; 1.
DR Pfam; PF16179; RHD_dimer; 1.
DR Pfam; PF00554; RHD_DNA_bind; 1.
DR PRINTS; PR01415; ANKYRIN.
DR PRINTS; PR00057; NFKBTNSCPFCT.
DR SMART; SM00248; ANK; 6.
DR SMART; SM00005; DEATH; 1.
DR SMART; SM00429; IPT; 1.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR SUPFAM; SSF47986; DEATH domain; 1.
DR SUPFAM; SSF81296; E set domains; 1.
DR SUPFAM; SSF49417; p53-like transcription factors; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 4.
DR PROSITE; PS50088; ANK_REPEAT; 6.
DR PROSITE; PS50254; REL_2; 1.
PE 4: Predicted;
KW ANK repeat {ECO:0000256|ARBA:ARBA00023043, ECO:0000256|PROSITE-
KW ProRule:PRU00023}; DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Reference proteome {ECO:0000313|Proteomes:UP000189705};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 1..115
FT /note="RHD"
FT /evidence="ECO:0000259|PROSITE:PS50254"
FT REPEAT 404..436
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 443..475
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 476..499
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 519..551
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 553..586
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 587..619
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REGION 288..352
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 299..348
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 849 AA; 93003 MW; 04C5A047B4C6FF29 CRC64;
MVVGFANLGI LHVTKKKVFE TLETRMIDAC KKGYNPGLLV HSELNYLQVE GCGERQLSDR
EKEIIRQAAF QQTKEMDLSV VRLMFTAFLP DSNGCFTRRL DPVISDPIYD SKAPNASNLK
IVRMDRTAGC VTGGEEIYLL CDKVQKDDIQ IRFYEEDENG GMWEGFGDFS PTDVHRQFAI
VFKTPKYRDV NITKPASVFV QLRRKSDLET SEPKPFLYYP EVKDKEEVQR KRQKLMPNFS
DSYGGGSGAG GGGGGMYGGG GGGAGSGFGY PSYGYTAFGG MHFHPGTTKS NTGMKHGLSS
DGHEQDRESC NKHNDKQNVK HGGKKEISGR DDSRLCGNNE EEDATLSHTA PDEANSRLQD
GVFLEKAMQL AKRHANALFD YAVTGDVKML LAVQRHLTAV QDDNGDNVLH LAIIHLHAEL
VRNLLEVMRD LNFDDIINMR NDLYQTPLHL AVITKQADVV EDLLKAGADV SSLDRHGNSV
LHLAAQEGDD NILGILLKHK KTSLMINLSD GEVFISCSVG LSASHMAVLA NSMSCLRLLI
AAGADINAQE QKSGRTALHL AVEQENISLA GCLLLEGDAY VDSTTYDGTT PLHIAAGRGS
TKLTALLKAA GADPHVENFE PLFDPEDVKG NDDEDEGIVP GTTPLDMATS WEVYDILNGK
PYESKVASDD LLAPGDMKEL NEDSKMQLYK LLDVPDPNKN WSTLAQKLGL GILNNAFRLS
PAPSKTLLDN YEVSGGTVKE LVDALKQMGY TEAIEIIQKA RSVPLTECSQ ENFTSKAPPL
SPFVPSTKQQ TGELYDIKFQ DTESMCDSGV ETSFRKLSFT CSESLNSKSI TLSKMALGYG
QEHSIQGKI
//
