ID A0A3Q0HHR9_ALLSI Unreviewed; 404 AA.
AC A0A3Q0HHR9;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE RecName: Full=Endoplasmic reticulum-Golgi intermediate compartment protein {ECO:0000256|RuleBase:RU369013};
GN Name=ERGIC3 {ECO:0000313|RefSeq:XP_025071506.1};
OS Alligator sinensis (Chinese alligator).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Crocodylia; Alligatoridae; Alligatorinae;
OC Alligator.
OX NCBI_TaxID=38654 {ECO:0000313|Proteomes:UP000189705, ECO:0000313|RefSeq:XP_025071506.1};
RN [1] {ECO:0000313|RefSeq:XP_025071506.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Plays a role in transport between endoplasmic reticulum and
CC Golgi. {ECO:0000256|RuleBase:RU369013}.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000256|RuleBase:RU369013}; Multi-pass membrane protein
CC {ECO:0000256|RuleBase:RU369013}. Endoplasmic reticulum-Golgi
CC intermediate compartment membrane {ECO:0000256|ARBA:ARBA00004457,
CC ECO:0000256|RuleBase:RU369013}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004457, ECO:0000256|RuleBase:RU369013}. Golgi
CC apparatus membrane {ECO:0000256|RuleBase:RU369013}; Multi-pass membrane
CC protein {ECO:0000256|RuleBase:RU369013}. Golgi apparatus, cis-Golgi
CC network membrane {ECO:0000256|ARBA:ARBA00004257}; Multi-pass membrane
CC protein {ECO:0000256|ARBA:ARBA00004257}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the ERGIC family.
CC {ECO:0000256|ARBA:ARBA00005648, ECO:0000256|RuleBase:RU369013}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|RuleBase:RU369013}.
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DR RefSeq; XP_025071506.1; XM_025215721.1.
DR AlphaFoldDB; A0A3Q0HHR9; -.
DR Proteomes; UP000189705; Unplaced.
DR GO; GO:0030134; C:COPII-coated ER to Golgi transport vesicle; IEA:UniProtKB-UniRule.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0033116; C:endoplasmic reticulum-Golgi intermediate compartment membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0006888; P:endoplasmic reticulum to Golgi vesicle-mediated transport; IEA:UniProtKB-UniRule.
DR GO; GO:0006890; P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum; IEA:UniProtKB-UniRule.
DR InterPro; IPR045888; Erv.
DR InterPro; IPR012936; Erv_C.
DR InterPro; IPR039542; Erv_N.
DR PANTHER; PTHR10984; ENDOPLASMIC RETICULUM-GOLGI INTERMEDIATE COMPARTMENT PROTEIN; 1.
DR PANTHER; PTHR10984:SF25; ENDOPLASMIC RETICULUM-GOLGI INTERMEDIATE COMPARTMENT PROTEIN 3; 1.
DR Pfam; PF07970; COPIIcoated_ERV; 1.
DR Pfam; PF13850; ERGIC_N; 1.
PE 3: Inferred from homology;
KW Endoplasmic reticulum {ECO:0000256|RuleBase:RU369013};
KW ER-Golgi transport {ECO:0000256|ARBA:ARBA00022892,
KW ECO:0000256|RuleBase:RU369013};
KW Golgi apparatus {ECO:0000256|RuleBase:RU369013};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU369013};
KW Reference proteome {ECO:0000313|Proteomes:UP000189705};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU369013};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU369013}; Transport {ECO:0000256|RuleBase:RU369013}.
FT SIGNAL 1..26
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 27..404
FT /note="Endoplasmic reticulum-Golgi intermediate compartment
FT protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5018000710"
FT TRANSMEM 365..388
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU369013"
FT DOMAIN 28..75
FT /note="Endoplasmic reticulum vesicle transporter N-
FT terminal"
FT /evidence="ECO:0000259|Pfam:PF13850"
FT DOMAIN 123..384
FT /note="Endoplasmic reticulum vesicle transporter C-
FT terminal"
FT /evidence="ECO:0000259|Pfam:PF07970"
FT REGION 88..108
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 404 AA; 46012 MW; D882D90558755ED3 CRC64;
MDSRQFRRHP VHDVLLLSWI LLCCSSELEF NVHPELYVDK SRGDKLKINI DVIFPHMPCA
YLSIDAMDVA GEQQLDVEHN LFKQRLDKDG SRVTPEAERH ELGKEEEKVF DPNSLDADRC
ESCYGAESED IRCCNTCDDV REAYRRRGWA FKNPDTIEQC KREGFSQKMQ EQKNEGCQVY
GFLEVNKVAG NFHFAPGKSF QQSHVHDQYD ALYQTSLIWE GLSRHHEPSR WNRCHCTTSR
VWPPSVGSAE NSSLLSSDCH LPLFSRGLKE ESALRSYCEL NVPLHLKTGK GPASMMFQYF
VKVVPTVYMK VDGEVVRTNQ FSVTRHEKIA NGLIGDQGLP GVFVLYELSP MMVKLTEKHR
SFTHFLTGVC AIIGGVFTVA GLIDSLIYHS SRAIQKKIEL GKTT
//
