ID A0A3Q0HID6_ALLSI Unreviewed; 1021 AA.
AC A0A3Q0HID6;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE RecName: Full=Nuclear factor NF-kappa-B p105 subunit {ECO:0000256|ARBA:ARBA00020838};
DE AltName: Full=Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 {ECO:0000256|ARBA:ARBA00032626};
GN Name=NFKB1 {ECO:0000313|RefSeq:XP_025071437.1};
OS Alligator sinensis (Chinese alligator).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Crocodylia; Alligatoridae; Alligatorinae;
OC Alligator.
OX NCBI_TaxID=38654 {ECO:0000313|Proteomes:UP000189705, ECO:0000313|RefSeq:XP_025071437.1};
RN [1] {ECO:0000313|RefSeq:XP_025071437.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR RefSeq; XP_025071437.1; XM_025215652.1.
DR AlphaFoldDB; A0A3Q0HID6; -.
DR Proteomes; UP000189705; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd08797; Death_NFkB1_p105; 1.
DR CDD; cd01177; IPT_NFkappaB; 1.
DR CDD; cd07935; RHD-n_NFkB1; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR Gene3D; 1.10.533.10; Death Domain, Fas; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR Gene3D; 2.60.40.340; Rel homology domain (RHD), DNA-binding domain; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR011029; DEATH-like_dom_sf.
DR InterPro; IPR000488; Death_domain.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR014756; Ig_E-set.
DR InterPro; IPR002909; IPT_dom.
DR InterPro; IPR033926; IPT_NFkappaB.
DR InterPro; IPR047096; NF-kB_p105_DD.
DR InterPro; IPR030503; NF-kB_p105_RHD_N.
DR InterPro; IPR000451; NFkB/Dor.
DR InterPro; IPR008967; p53-like_TF_DNA-bd_sf.
DR InterPro; IPR030492; RHD_CS.
DR InterPro; IPR032397; RHD_dimer.
DR InterPro; IPR011539; RHD_DNA_bind_dom.
DR InterPro; IPR037059; RHD_DNA_bind_dom_sf.
DR PANTHER; PTHR24169:SF9; NUCLEAR FACTOR NF-KAPPA-B P105 SUBUNIT; 1.
DR PANTHER; PTHR24169; NUCLEAR FACTOR NF-KAPPA-B PROTEIN; 1.
DR Pfam; PF00023; Ank; 1.
DR Pfam; PF12796; Ank_2; 2.
DR Pfam; PF00531; Death; 1.
DR Pfam; PF16179; RHD_dimer; 1.
DR Pfam; PF00554; RHD_DNA_bind; 1.
DR PRINTS; PR01415; ANKYRIN.
DR PRINTS; PR00057; NFKBTNSCPFCT.
DR SMART; SM00248; ANK; 6.
DR SMART; SM00005; DEATH; 1.
DR SMART; SM00429; IPT; 1.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR SUPFAM; SSF47986; DEATH domain; 1.
DR SUPFAM; SSF81296; E set domains; 1.
DR SUPFAM; SSF49417; p53-like transcription factors; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 4.
DR PROSITE; PS50088; ANK_REPEAT; 6.
DR PROSITE; PS01204; REL_1; 1.
DR PROSITE; PS50254; REL_2; 1.
PE 4: Predicted;
KW Activator {ECO:0000256|ARBA:ARBA00023159};
KW ANK repeat {ECO:0000256|ARBA:ARBA00023043, ECO:0000256|PROSITE-
KW ProRule:PRU00023}; Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Reference proteome {ECO:0000313|Proteomes:UP000189705};
KW S-nitrosylation {ECO:0000256|ARBA:ARBA00022799};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 80..287
FT /note="RHD"
FT /evidence="ECO:0000259|PROSITE:PS50254"
FT REPEAT 576..608
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 615..647
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 648..671
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 691..723
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 725..758
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 759..791
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REGION 460..524
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 471..520
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1021 AA; 112113 MW; 728BE1E0A00DA08B CRC64;
MRLKRKLKKI YTNILLLICI SVFVLRDAAV LKILYSLNMA EDPYIMGVSD PQMFTVDQFM
GMNAIFNNSG YITSDIPLRA DGPYLQIIEQ PKQRGFRFRY VCEGPSHGGL PGASSEKNKK
SYPQVRICNY VGPAKVIVQL VTSGKSVHLH AHSLVGKYCE DGVCTVNAGP KDMVVGFANL
GILHVTKKKV FETLETRMID ACKKGYNPGL LVHSELNYLQ VEGCGERQLS DREKEIIRQA
AFQQTKEMDL SVVRLMFTAF LPDSNGCFTR RLDPVISDPI YDSKAPNASN LKIVRMDRTA
GCVTGGEEIY LLCDKVQKDD IQIRFYEEDE NGGMWEGFGD FSPTDVHRQF AIVFKTPKYR
DVNITKPASV FVQLRRKSDL ETSEPKPFLY YPEVKDKEEV QRKRQKLMPN FSDSYGGGSG
AGGGGGGMYG GGGGGAGSGF GYPSYGYTAF GGMHFHPGTT KSNTGMKHGL SSDGHEQDRE
SCNKHNDKQN VKHGGKKEIS GRDDSRLCGN NEEEDATLSH TAPDEANSRL QDGVFLEKAM
QLAKRHANAL FDYAVTGDVK MLLAVQRHLT AVQDDNGDNV LHLAIIHLHA ELVRNLLEVM
RDLNFDDIIN MRNDLYQTPL HLAVITKQAD VVEDLLKAGA DVSSLDRHGN SVLHLAAQEG
DDNILGILLK HKKTSLMINL SDGEVFISCS VGLSASHMAV LANSMSCLRL LIAAGADINA
QEQKSGRTAL HLAVEQENIS LAGCLLLEGD AYVDSTTYDG TTPLHIAAGR GSTKLTALLK
AAGADPHVEN FEPLFDPEDV KGNDDEDEGI VPGTTPLDMA TSWEVYDILN GKPYESKVAS
DDLLAPGDMK ELNEDSKMQL YKLLDVPDPN KNWSTLAQKL GLGILNNAFR LSPAPSKTLL
DNYEVSGGTV KELVDALKQM GYTEAIEIIQ KARSVPLTEC SQENFTSKAP PLSPFVPSTK
QQTGELYDIK FQDTESMCDS GVETSFRKLS FTCSESLNSK SITLSKMALG YGQEHSIQGK
I
//
