ID A0A3Q0HK99_ALLSI Unreviewed; 1031 AA.
AC A0A3Q0HK99;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=Solute carrier family 12 member 7 isoform X3 {ECO:0000313|RefSeq:XP_025070863.1};
GN Name=LOC102379377 {ECO:0000313|RefSeq:XP_025070863.1};
OS Alligator sinensis (Chinese alligator).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Crocodylia; Alligatoridae; Alligatorinae;
OC Alligator.
OX NCBI_TaxID=38654 {ECO:0000313|Proteomes:UP000189705, ECO:0000313|RefSeq:XP_025070863.1};
RN [1] {ECO:0000313|RefSeq:XP_025070863.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=chloride(in) + K(+)(in) = chloride(out) + K(+)(out);
CC Xref=Rhea:RHEA:72427, ChEBI:CHEBI:17996, ChEBI:CHEBI:29103;
CC Evidence={ECO:0000256|ARBA:ARBA00034453};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the SLC12A transporter family.
CC {ECO:0000256|ARBA:ARBA00010593}.
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DR RefSeq; XP_025070863.1; XM_025215078.1.
DR AlphaFoldDB; A0A3Q0HK99; -.
DR Proteomes; UP000189705; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015379; F:potassium:chloride symporter activity; IEA:InterPro.
DR Gene3D; 1.20.1740.10; Amino acid/polyamine transporter I; 1.
DR InterPro; IPR004841; AA-permease/SLC12A_dom.
DR InterPro; IPR000076; KCL_cotranspt.
DR InterPro; IPR018491; SLC12_C.
DR InterPro; IPR004842; SLC12A_fam.
DR NCBIfam; TIGR00930; 2a30; 1.
DR PANTHER; PTHR11827:SF47; SOLUTE CARRIER FAMILY 12 MEMBER 7; 1.
DR PANTHER; PTHR11827; SOLUTE CARRIER FAMILY 12, CATION COTRANSPORTERS; 1.
DR Pfam; PF00324; AA_permease; 2.
DR Pfam; PF03522; SLC12; 2.
DR PRINTS; PR01081; KCLTRNSPORT.
PE 3: Inferred from homology;
KW Chloride {ECO:0000256|ARBA:ARBA00023214};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Potassium {ECO:0000256|ARBA:ARBA00022958};
KW Potassium transport {ECO:0000256|ARBA:ARBA00022538};
KW Reference proteome {ECO:0000313|Proteomes:UP000189705};
KW Symport {ECO:0000256|ARBA:ARBA00022847};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022847}.
FT TRANSMEM 61..84
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 96..119
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 140..173
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 193..212
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 219..238
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 358..378
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 398..424
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 444..462
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 498..516
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 522..544
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 556..580
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 67..240
FT /note="Amino acid permease/ SLC12A"
FT /evidence="ECO:0000259|Pfam:PF00324"
FT DOMAIN 358..637
FT /note="Amino acid permease/ SLC12A"
FT /evidence="ECO:0000259|Pfam:PF00324"
FT DOMAIN 651..766
FT /note="SLC12A transporter C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03522"
FT DOMAIN 768..1031
FT /note="SLC12A transporter C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03522"
SQ SEQUENCE 1031 AA; 114632 MW; 0D4FA1FA44FAE845 CRC64;
MDKGIIYEGK NMALFEEEMD SNPMVSSLLN KLANYTNLTQ GVIEHEADED SKRREIKAPR
MGTFIGVYLP CLQNILGVIL FLRLTWIVGT AGVLESFIIV FMCCACTMLT AISMSAIATN
GVVPAGGSYY MISRSLGPEF GGAVGLCFYL GTTFAGAMYI LGTIEILLTY ISPSAAIFKS
EDGEEAEAML NNMRVYGTCI IALMAIVVFV GVKYVNKLAL VFLACVILSI IAIYAGVIKT
AFDPPDFRIC LLGNRTLSRR NFDTCAKFTK IDNKTETTRL WRLFCDSALL NATCDEYFSL
NNVTEIQGIP GVSSGVLIDN LWSTYSDKGS VVEKRELPSL TGTEETKVAG LPYVFTDIMT
FFTMLVGIYF PSVTGIMAGS NRSGDLKDAQ KSIPTGTILA ISTTSFIYLS CIVLFGACIE
GVILRDKFGE AVNGNLVIGT LAWPSPWVIV IGSFFSTCGA GLQSLTGAPR LLQAISRDGI
VPFLHVFGHG KANGEPTWAL LLTACICEIG ILIASLDSVA PILSMFFLMC YMFVNLACAV
QTLLRTPNWR PRFKFYHWTL SFLGMSLCLA LMFICSWYYA LIAMVIAGCI YKYIEYRGAE
KEWGDGIRGL SLNAARYALL RVEAGHPHTK NWRPQVLVLL NLDSEQLVKH PRLLSFTSQL
KAGKGLTIVG SVLQGIYLDK CVEVQKAEEN VKSLMAIEKT KGFCQIVVSP SLRDGVSHLI
QSAGLGGMKH NTVLMAWPQS WKLTDNPFSW RNFVDTVRET TAAQQALLVA KNIDLFPANQ
ERFSEGNIDV WWIVHDGGML MLLPFLIRQH KVWRKCKMRI FTVAQMDDNS IQMKKDLQMF
LYHLRLNAEV EVVEMFENDI SAFTYEKTLV MEQRSQMLKQ MQLSKNERER EAQLIHDRNT
ASHSAAVVQA NAAAAAPERV QMTWTKEKLV SEKHKNKETN LTGFKDIFNL KPEWGNLNQT
NVRRMHTAVK LNGVVLNKSQ DAQLVLLNMP GPPKSKKGDE NYMEFLEVLT DGLNRVLLVR
GGGREVITIY S
//
