ID A0A3Q0HLA4_ALLSI Unreviewed; 1969 AA.
AC A0A3Q0HLA4;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=Myotubularin-related protein 5 isoform X1 {ECO:0000313|RefSeq:XP_025071223.1};
GN Name=SBF1 {ECO:0000313|RefSeq:XP_025071223.1};
OS Alligator sinensis (Chinese alligator).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Crocodylia; Alligatoridae; Alligatorinae;
OC Alligator.
OX NCBI_TaxID=38654 {ECO:0000313|Proteomes:UP000189705, ECO:0000313|RefSeq:XP_025071223.1};
RN [1] {ECO:0000313|RefSeq:XP_025071223.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the protein-tyrosine phosphatase family. Non-
CC receptor class myotubularin subfamily. {ECO:0000256|ARBA:ARBA00007471}.
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DR RefSeq; XP_025071223.1; XM_025215438.1.
DR STRING; 38654.A0A3Q0HLA4; -.
DR KEGG; asn:102371339; -.
DR InParanoid; A0A3Q0HLA4; -.
DR OrthoDB; 3195274at2759; -.
DR Proteomes; UP000189705; Unplaced.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR CDD; cd13340; PH-GRAM_MTMR5; 1.
DR CDD; cd01235; PH_Sbf1_hMTMR5; 1.
DR Gene3D; 3.30.450.200; -; 1.
DR Gene3D; 3.40.50.11500; -; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR001194; cDENN_dom.
DR InterPro; IPR005112; dDENN_dom.
DR InterPro; IPR043153; DENN_C.
DR InterPro; IPR004182; GRAM.
DR InterPro; IPR010569; Myotubularin-like_Pase_dom.
DR InterPro; IPR030564; Myotubularin_fam.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR InterPro; IPR022096; SBF1/SBF2.
DR InterPro; IPR037516; Tripartite_DENN.
DR InterPro; IPR005113; uDENN_dom.
DR PANTHER; PTHR10807; MYOTUBULARIN-RELATED; 1.
DR PANTHER; PTHR10807:SF43; MYOTUBULARIN-RELATED PROTEIN 5; 1.
DR Pfam; PF03455; dDENN; 1.
DR Pfam; PF02141; DENN; 1.
DR Pfam; PF02893; GRAM; 1.
DR Pfam; PF06602; Myotub-related; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF12335; SBF2; 1.
DR Pfam; PF03456; uDENN; 1.
DR SMART; SM00801; dDENN; 1.
DR SMART; SM00799; DENN; 1.
DR SMART; SM00568; GRAM; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00800; uDENN; 1.
DR SUPFAM; SSF52799; (Phosphotyrosine protein) phosphatases II; 1.
DR SUPFAM; SSF50729; PH domain-like; 2.
DR PROSITE; PS50211; DENN; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS51339; PPASE_MYOTUBULARIN; 1.
PE 3: Inferred from homology;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658};
KW Reference proteome {ECO:0000313|Proteomes:UP000189705}.
FT DOMAIN 37..462
FT /note="UDENN"
FT /evidence="ECO:0000259|PROSITE:PS50211"
FT DOMAIN 1162..1695
FT /note="Myotubularin phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS51339"
FT DOMAIN 1863..1967
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 1116..1155
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1360..1379
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1782..1801
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1822..1849
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1141..1155
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1787..1801
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1969 AA; 220841 MW; A025CC2F97157F2C CRC64;
MEVAPNTCNH FCSCGGRAHV STNSSHAEQG PGITSHFLAC AAWQEQLSGG SGDGQGQILQ
RFPEKDWEDN PFPQGIELFC QPSGWQLFTE RNPPNFFVAV LTDINSERHY CACFTFWETV
ESVQPQSHTR NGEEEEEEVD SSLPVQPVQL FAPKSLVLVS RLDHTEVFRN SLGLIYTIYV
DGLNVSLENV IGNLLTCTIP ITGGAQRTIS LGAGDRQVIQ TPINDSLPVS SCSVALLFRQ
LGITNVLYLF CAALTEHKIL FLSSSYQRLT DACRALLAIM FPLKYSFTYV PILPAQLLEV
LSTPTPFIIG VSSIFHAETQ ELLDVVIADL DGGTVTIPEC VHISLLPEPL LQQTREALSM
VLDPELEVAD VAFPPSTISA SSLKMQDKEI RAVFLRLFAQ LLQGYRWCLH IIRIHPEPVI
RFHKAAFLGQ RGLVEDDFLT KVLEGMAFAG FVTERGAPYR PIDLFDELVA YEVKRMHADK
GNKQKILRHI KELAEKLYKN ENPYPAVTMH KVQKPAEGCH LRLHQKPFPR LDEGTVQWII
DQATAKMQTA PPAVKAEKKC MVPSGTPIAA ILERNGNALA NSARRLEVVR NCISYVFENK
MLEAKKLLPA VLRAMKGRAA RHCLTQELNL HVQQNRAVLD HQQFDFVVRM MNCCLQDCTA
MDEHGIAAAL LPLVTAFCRK LSPGITQFAY SCVQEHVVWT NIQFWEAMFY CDVQNHIRAL
YLETTEENHA GEEGQREEKV ALEIASEQLR LWPTMSREKQ QELMQKEEST VFSQAIHYAN
RMSYLLLPLD TSKSRLLRSS GLGDVESVSN SFVTNSIAGS VAESYDTESG FEDAESSDVA
NYVVRFINRF VDKVCTESGV TNEHLKGLHI MIPDIVQMHI ETLDAVHRES KRLPPIQKPK
LLRPSLLVGE ECVMEGLRVY LMPDGREEAA GGNIGGPPLL PAEGAIFLTT YRIIFKGTPT
DPLVGEQVVI RSFPIASLTK EKKISIQAQM DPLVQEGLQL RSCTFQLLRI AFDEVASESA
EVFRKHLHKL RYPQHVRSTF AFTVGQSPKQ AMQPKAKEKN PSLSSHQVTD MFQGLTVGVL
SLGHLSHSTT TLSRNLVKNA KKSIGRQYVT RKKYTPPTWE QRGTQQFPED NEDEISVSEE
MDRSTLTPST TIKPSDKMTM SHLVERACCR DYQRLGLGTL SNSLTRSKSE PFRISTVNRM
YAICRSYPGL LIVPQNIQDN TIQRISRCYR QNRFPVVCWR NARTKAVLLR SGGLHGKGVA
GLFKAPNAPT SAGPSQTDST SLEQEKYLQA VINSMPHYAD AGGRNTLSGF TSAYMGSSDS
CDKRQPKLGS LMKQVLGGKD DGSGTVSRGG HRARVVTLSI PKGPPARGRD SPRAGKWGSI
RASGRASSYA LNVDVGSRLA SKDLLSAQHN GAPAEASFLR QHHASLYIIG DKSQLKGVKP
DPLQHWEAVP IEVFDVRQVK ASFKKLLKAC VPACVAAEPS LTYLRSLEDS EWLSQIHKIL
QISVLVVELL DTGSSVLVSL EDGWDITTQV VSLVQLLSDP YYRTMEGFRL LVEKEWLSFG
HRFSHRGAQT LTSQSSGFAP VFLQFLDCVH QIHLQFPMEF EFSQYYLKFL SYHHVSNRFR
TFLLDSDYER IELGLLYEEK GERKCQQAYK SVWDYIDRLN KKTPVFFNYM YAPEDSEVLR
PYSNISNLKV WDYYTAETLA EGPSYDWELA QGPAEPAEEA ERQETGAPQS KRCIIWPCYD
NRGRVEPDAI SKLLEELHNL EMELGHMPER WKDTWDKVKA SQRTEARQEG SRMASSSLLM
SSSLSHQRRS LGVYLQEPGA GSTLNLSLDS DTSSTSTPSS GKQGGRRSTS TLYNQFQMSE
SENRSYEGSL YKKGAFMKPW KPRWFVLDKT KHQLRYYDNR SDTECKGVID LAEVESITPG
TPTMGAPKTV EEKAFFDLKT TKRVYNFCAQ DAPLAQQWID RIQSCLSDA
//
