ID A0A3Q0HLP2_ALLSI Unreviewed; 955 AA.
AC A0A3Q0HLP2;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE SubName: Full=Rho guanine nucleotide exchange factor 10-like protein isoform X3 {ECO:0000313|RefSeq:XP_025072592.1};
GN Name=ARHGEF10L {ECO:0000313|RefSeq:XP_025072592.1};
OS Alligator sinensis (Chinese alligator).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Crocodylia; Alligatoridae; Alligatorinae;
OC Alligator.
OX NCBI_TaxID=38654 {ECO:0000313|Proteomes:UP000189705, ECO:0000313|RefSeq:XP_025072592.1};
RN [1] {ECO:0000313|RefSeq:XP_025072592.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR RefSeq; XP_025072592.1; XM_025216807.1.
DR AlphaFoldDB; A0A3Q0HLP2; -.
DR Proteomes; UP000189705; Unplaced.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 2.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR039919; ARHGEF10/ARHGEF17.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR PANTHER; PTHR12877; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR PANTHER; PTHR12877:SF16; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 10-LIKE PROTEIN; 1.
DR Pfam; PF19057; PH_19; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR Pfam; PF19056; WD40_2; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS50010; DH_2; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000189705}.
FT DOMAIN 65..147
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT REGION 1..34
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 812..842
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 162..189
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 11..30
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 822..842
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 955 AA; 104964 MW; D87F0394926E35F9 CRC64;
MWKKRHSIEN GSILARSSSS SSSVSVSGDS EEEDTGFLEV TVTDMRHPPP ELGPMPEGLS
PQQVVRRHIL GSIVQSEGSY VDSLRRILQD YRNPLMEMEP KVLSARKCQV VFFRLKEILQ
CHSMFQIALF SRVAEWDATE KIGDLFVASD MLKNTPKGHP ERLSLQLALT ELETLAEKLN
EQKRVADQVA EIQQLTKSIS DRSSLNKLLN SGQRQLLLCE TLTETVYGDR GQLIKSKERK
VFLLNDMLVC ANINFKGQLE ISSLVPLGPK YVVKWNTALP QVQVVEVGQE NSTYHKDNVV
IQNAGAKKHV PTSQSSHNKV YLGPPRLFQE LQDLQKDLAV VEQITQLIST LHGTYQNLNM
TVAQDWCLAL QRMMRVKEEE IHSANKCRLR LLLPGKPDKS GRPISFMVVF ITPNPLSKIS
WVNRLHLAKL GLRDENQPGW LCPDEDKKTK APFWCPILAC HMSAFSSKAL DLQLGAVVHN
PVQSSLLGFS AVSTSLPQGY LWVGGGQEGA GGQVEIFSLN RSVPRTVKSF PVASQVLCME
YIPEKSGEEQ EQEKTEDSRA TAEQASALHP TICLGLQDGS ITVYGSVDTG TQCLLTCKSP
GRQPVLCLKH SPDYLFAGLQ NGIVAAYART SGGLWDLEAK PTCLQVGTGP VRVLLTLDDT
LWASCANQVT VLDAASLKAQ DTFEAHPDKE ASVTHMIKAG SGVWMAFSSG SSIRLFHTET
LEHLQEINIA TRTTFVLPGQ KNVRVTSLLI CQGLLWVGTD QGIIVLLPVP RLEGIPKITG
KGMVSLNGHC GPVEFLAMAV STLAPDILKS DKEEEGGEAV CGDEEKPEGR CPEPAAQDSH
LGREMRKKGI LLQYRLRSTS HLPGELLSVR EAPAAAGAGT LEHTEEDGSI YEMADDPDVW
VRSRPCARDT HRKEISSLAI ISGGRGYRSF NANSKGPACS ETDSTLLIWQ VPLTL
//
