ID A0A3Q0HMZ4_ALLSI Unreviewed; 1420 AA.
AC A0A3Q0HMZ4;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 19.
DE SubName: Full=Bromodomain-containing protein 4 isoform X2 {ECO:0000313|RefSeq:XP_025071950.1};
GN Name=BRD4 {ECO:0000313|RefSeq:XP_025071950.1};
OS Alligator sinensis (Chinese alligator).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Crocodylia; Alligatoridae; Alligatorinae;
OC Alligator.
OX NCBI_TaxID=38654 {ECO:0000313|Proteomes:UP000189705, ECO:0000313|RefSeq:XP_025071950.1};
RN [1] {ECO:0000313|RefSeq:XP_025071950.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Chromosome {ECO:0000256|ARBA:ARBA00004286}.
CC Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR RefSeq; XP_025071950.1; XM_025216165.1.
DR Proteomes; UP000189705; Unplaced.
DR GO; GO:0005694; C:chromosome; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR CDD; cd05497; Bromo_Brdt_I_like; 1.
DR CDD; cd05498; Bromo_Brdt_II_like; 1.
DR Gene3D; 1.20.1270.220; -; 1.
DR Gene3D; 1.20.920.10; Bromodomain-like; 2.
DR InterPro; IPR031354; BRD4_CDT.
DR InterPro; IPR043508; Bromo_Brdt_I.
DR InterPro; IPR043509; Bromo_Brdt_II.
DR InterPro; IPR001487; Bromodomain.
DR InterPro; IPR036427; Bromodomain-like_sf.
DR InterPro; IPR018359; Bromodomain_CS.
DR InterPro; IPR027353; NET_dom.
DR InterPro; IPR038336; NET_sf.
DR PANTHER; PTHR22880:SF143; BROMODOMAIN-CONTAINING PROTEIN 4; 1.
DR PANTHER; PTHR22880; FALZ-RELATED BROMODOMAIN-CONTAINING PROTEINS; 1.
DR Pfam; PF17035; BET; 1.
DR Pfam; PF17105; BRD4_CDT; 1.
DR Pfam; PF00439; Bromodomain; 2.
DR PRINTS; PR00503; BROMODOMAIN.
DR SMART; SM00297; BROMO; 2.
DR SUPFAM; SSF47370; Bromodomain; 2.
DR PROSITE; PS00633; BROMODOMAIN_1; 1.
DR PROSITE; PS50014; BROMODOMAIN_2; 2.
DR PROSITE; PS51525; NET; 1.
PE 4: Predicted;
KW Bromodomain {ECO:0000256|ARBA:ARBA00023117, ECO:0000256|PROSITE-
KW ProRule:PRU00035}; Chromosome {ECO:0000256|ARBA:ARBA00022454};
KW Reference proteome {ECO:0000313|Proteomes:UP000189705};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 141..213
FT /note="Bromo"
FT /evidence="ECO:0000259|PROSITE:PS50014"
FT DOMAIN 431..503
FT /note="Bromo"
FT /evidence="ECO:0000259|PROSITE:PS50014"
FT DOMAIN 665..747
FT /note="NET"
FT /evidence="ECO:0000259|PROSITE:PS51525"
FT REGION 90..125
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 238..289
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 305..413
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 524..679
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 738..978
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 996..1397
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 90..111
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 256..289
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 305..334
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 357..379
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 380..405
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 527..545
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 566..580
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 612..636
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 637..654
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 662..679
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 759..773
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 794..810
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 820..854
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 879..893
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 946..964
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1017..1032
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1036..1079
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1121..1147
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1221..1237
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1249..1269
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1270..1334
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1335..1381
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1382..1397
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1420 AA; 159772 MW; 6561378E85224D2E CRC64;
MLPEKMFPRP QNSTCANRVG TIPAVLCSSN DMCDFSKAHL DFGEDGNFKH SFTELVPGEE
CDGINSMSVE SGPGTRLRNL PVMGDGLETT QMSTTQSQAQ PQQGSTVGVN PPPPETSNPN
KPKRQTNQLQ YLLKVVLKTL WKHQFAWPFQ QPVDAVKLNL PDYYKIIKTP MDMGTIKKRL
ENNYYWNAQE CIQDFNTMFT NCYIYNKPGD DIVLMAEALE KLFLQKISEM TQEETEIVIS
QTKGRGRGRK EAVTSKPGSS MVQNATQASS PVQTQPPQQN LQSAQATHSF SSVTPDLIVQ
TPVMTVVPPQ PPAPPPPAPP ASVPPAPAPQ PIQAHPSVIP TAAQPVKTKK GVKRKADTTT
PTTIDPIHES SSLPTETKTT KLGPRRESSR PVKPPKKDVP DSQQHVVEKS SKVSEQLKHC
SSIIKEMFAK KHAAYAWPFY KPVDVEALGL HDYCDIIKHP MDLSTIKSKL ESREYRDAQE
FAGDVRLMFS NCYKYNPADH EVVAMARKLQ DVFEMRFAKM PDEPEEPVIP ASSPVVVPPP
TKVAPPSSSD SSSDSSSDSD SSSDDSEEER AQRLAELQEQ LKAVHEQLAA LSQPQQNKPK
KKEKDKKEKK KEKHKKKEEL EESKKSKTKE PPPKKAKKSN SNSSNSSSKK EPVTVKNSKP
PPAYESEEEE KCKPMSYEEK RQLSLDINKL PGEKLGRVVH IIQSREPSLK NSNPDEIEID
FETLKPSTLR ELERYVTSCL RKKRKPQAEK VDVIAGSSKM KGFSSSESES TSESSSSDSE
DSETEMAPKM KKKGHSGREQ KKHHHHHHPQ VQQQPQQQPQ QLQPQPPPPP PPPVPQQAPP
PMKSSPPPFV PAQVPVMEHP LQGNMFDTMT HFTQPIMHLP QPEMPPHLPQ QPEHSTPPHL
NQHAVVSPPA LHNALPQQPS RPSNRAAALP PKPSRPPAVS PAISQQPMLP QPPLPQPPQV
LLEDEEPPAP HHSLSLSTSQ MQLYLQQLQK VQPQTPLLPS VKVQSQPQPP LQPPAHPSVQ
QLQHQPQQRP MHMQPMQFPP HIPQPQPPPQ QHPPPPQQPP PPQPQQQPQP PPQQPPQQPA
KPQQVIQHHP SPRHHKPDPY STGHLREAPS PLMMHSPQMP QFQGLVHQSP PQQNIQPKKQ
EMRAASVVQS QPLVVKEEKM HSPVIRNETF SPTLRQDPPK HPESIKPPAH IQQRAEMKPT
EGGRPVIRPP EQTAPPPGIQ DKDRQKQEPK TPVAPKKDLK IKNMGSWASL VQKHPTTPSS
TVKSSSDSFE QFKRAAREKE EREKALKAQA EQVEKEKERL RREQERMRSR DDEDAMEQAR
RVHEEVRRRQ EQQQQQQQHH QQQQQQQQQQ QQQQQQQVSA AASAPQAQSS QPQSSQSMLD
QQREMARKRE QERRRREAMA ATIDMNFQSD LLAIFEENLF
//
