ID   A0A3Q0IV30_DIACI        Unreviewed;      1078 AA.
AC   A0A3Q0IV30;
DT   13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT   13-FEB-2019, sequence version 1.
DT   27-MAR-2024, entry version 20.
DE   RecName: Full=Alpha-mannosidase {ECO:0000256|RuleBase:RU361199};
DE            EC=3.2.1.- {ECO:0000256|RuleBase:RU361199};
GN   Name=LOC103510204 {ECO:0000313|RefSeq:XP_026680122.1};
OS   Diaphorina citri (Asian citrus psyllid).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Paraneoptera; Hemiptera; Sternorrhyncha; Psylloidea; Psyllidae;
OC   Diaphorininae; Diaphorina.
OX   NCBI_TaxID=121845 {ECO:0000313|Proteomes:UP000079169, ECO:0000313|RefSeq:XP_026680122.1};
RN   [1] {ECO:0000313|RefSeq:XP_026680122.1}
RP   IDENTIFICATION.
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC         Evidence={ECO:0000256|RuleBase:RU361199};
CC       Note=Binds 1 zinc ion per subunit. {ECO:0000256|RuleBase:RU361199};
CC   -!- SIMILARITY: Belongs to the glycosyl hydrolase 38 family.
CC       {ECO:0000256|ARBA:ARBA00009792, ECO:0000256|RuleBase:RU361199}.
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DR   RefSeq; XP_026680122.1; XM_026824321.1.
DR   AlphaFoldDB; A0A3Q0IV30; -.
DR   STRING; 121845.A0A3Q0IV30; -.
DR   PaxDb; 121845-A0A3Q0IV30; -.
DR   KEGG; dci:103510204; -.
DR   OrthoDB; 5474711at2759; -.
DR   Proteomes; UP000079169; Unplaced.
DR   GO; GO:0004559; F:alpha-mannosidase activity; IEA:InterPro.
DR   GO; GO:0030246; F:carbohydrate binding; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0006013; P:mannose metabolic process; IEA:InterPro.
DR   Gene3D; 3.20.110.10; Glycoside hydrolase 38, N terminal domain; 2.
DR   Gene3D; 1.20.1270.50; Glycoside hydrolase family 38, central domain; 1.
DR   Gene3D; 2.60.40.1180; Golgi alpha-mannosidase II; 1.
DR   InterPro; IPR011013; Gal_mutarotase_sf_dom.
DR   InterPro; IPR011330; Glyco_hydro/deAcase_b/a-brl.
DR   InterPro; IPR011682; Glyco_hydro_38_C.
DR   InterPro; IPR015341; Glyco_hydro_38_cen.
DR   InterPro; IPR037094; Glyco_hydro_38_cen_sf.
DR   InterPro; IPR000602; Glyco_hydro_38_N.
DR   InterPro; IPR027291; Glyco_hydro_38_N_sf.
DR   InterPro; IPR028995; Glyco_hydro_57/38_cen_sf.
DR   InterPro; IPR013780; Glyco_hydro_b.
DR   PANTHER; PTHR11607; ALPHA-MANNOSIDASE; 1.
DR   PANTHER; PTHR11607:SF71; ALPHA-MANNOSIDASE; 1.
DR   Pfam; PF09261; Alpha-mann_mid; 1.
DR   Pfam; PF07748; Glyco_hydro_38C; 1.
DR   Pfam; PF01074; Glyco_hydro_38N; 2.
DR   SMART; SM00872; Alpha-mann_mid; 1.
DR   SUPFAM; SSF88688; Families 57/38 glycoside transferase middle domain; 1.
DR   SUPFAM; SSF74650; Galactose mutarotase-like; 1.
DR   SUPFAM; SSF88713; Glycoside hydrolase/deacetylase; 2.
PE   3: Inferred from homology;
KW   Glycosidase {ECO:0000256|ARBA:ARBA00023295, ECO:0000256|RuleBase:RU361199};
KW   Hydrolase {ECO:0000256|RuleBase:RU361199};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW   ECO:0000256|RuleBase:RU361199};
KW   Reference proteome {ECO:0000313|Proteomes:UP000079169};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|RuleBase:RU361199}.
FT   DOMAIN          418..506
FT                   /note="Glycoside hydrolase family 38 central"
FT                   /evidence="ECO:0000259|SMART:SM00872"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|RefSeq:XP_026680122.1"
SQ   SEQUENCE   1078 AA;  124509 MW;  3B30E7222C557602 CRC64;
     VFLVPHSHND PGWLKTFESY YHSQTRMILN NMVEKLVQHP NMTFIWSEIS FFSQWWESVH
     PTKRNIVKKL IAEGRLEMVT GGWVMTDEAT SHIFAMVDQL IEGHQWLKNN LGIQPRSGWS
     VDPFGHGATV PYLLKSSGFE GGAVIQRIHY AWKRWFAEQE MGDFKWRQTW DNDGHTDFLV
     HNMPFDIYSI KHSCGPHPQI CLSYDFRKVP GEYTEYSMRS VPIDNENVKQ KAETLLEEYG
     RTGSLFPHNT VMTLLGDDFR YDRDMEWDQQ YRNYKKLFDY INSHKHIYNA EVSFGTPSDY
     FTNTEYSMRS VPIDNENVKQ KAETLLEEYG RTGSLFPHNT VMTLLGDDFR YDRDMEWDQQ
     YRNYKKLFDY INSHKHIYNA EVSFGTPSDY FNAVRERMSS FKTLKGDFFV YSDIFAEAYW
     SGYYTTRPYW KILDRELESN LRSAEILYTV ALNKARKQCY NNTVKVLERD YEKLVRARQS
     LGLFQHHDAI TGTSKAYVMH DYALKLYEGI QDSIFVQGFS AQSLLLHSDN TPSSSNTCLL
     VPSSDRESYE KLPHKIVINF HNDEPKKVVL FNSLGQHRQD VIRLKVSKPN VRVLSPDGGP
     VIYQINPVWN SSQPETTAEQ PSETTIEMVR NQYELEFVVE LPPLSLMVYT IEVIPRKQNL
     EAHAIVYCKK CHRHSSFITK NMLTGDIQLE NHVLKLLIDG NSGLLRSITQ KKTNKVTHCG
     LEFSAYTSAQ FHSGAYLFMP EPNTRDSERE ILDDIPNHKI VITSGPVSSQ LIVLYGNLLV
     HTITIYHVSG PLSQGIYIEN IVDFDIPPKN RETELFMRFN SDLMNGEPPE FYTDLNGLSM
     QRRVKVERIN IEGNYFPITT SAFIQDPDRR LTLLVNHAQG AAAWQPGWLE VMLDRRTLYD
     DARGMGEGIV DNKRTLCKYW LLLEDISSVD PSLYQSPSLV ANQLSNGLNY PPNIFILESS
     DTSIKQDQLR SEVFLVSKPL PCDVHLMNFR TLADQTFMQF PSSSSLMLLQ RQGFACNVGS
     DYSIPKCSLN TNPKSNPSAF HSKTLFNDLH VSSIRKTSLT GLRSEEEITY LRLVSINI
//