ID   A0A3Q0IZA0_DIACI        Unreviewed;      1483 AA.
AC   A0A3Q0IZA0;
DT   13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT   13-FEB-2019, sequence version 1.
DT   27-MAR-2024, entry version 21.
DE   SubName: Full=Otoferlin {ECO:0000313|RefSeq:XP_026681577.1};
GN   Name=LOC103512257 {ECO:0000313|RefSeq:XP_026681577.1};
OS   Diaphorina citri (Asian citrus psyllid).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Paraneoptera; Hemiptera; Sternorrhyncha; Psylloidea; Psyllidae;
OC   Diaphorininae; Diaphorina.
OX   NCBI_TaxID=121845 {ECO:0000313|Proteomes:UP000079169, ECO:0000313|RefSeq:XP_026681577.1};
RN   [1] {ECO:0000313|RefSeq:XP_026681577.1}
RP   IDENTIFICATION.
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
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DR   RefSeq; XP_026681577.1; XM_026825776.1.
DR   STRING; 121845.A0A3Q0IZA0; -.
DR   PaxDb; 121845-A0A3Q0IZA0; -.
DR   KEGG; dci:103512257; -.
DR   OrthoDB; 991411at2759; -.
DR   Proteomes; UP000079169; Unplaced.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   CDD; cd04018; C2C_Ferlin; 1.
DR   CDD; cd04017; C2D_Ferlin; 1.
DR   CDD; cd08374; C2F_Ferlin; 1.
DR   Gene3D; 2.60.40.150; C2 domain; 4.
DR   InterPro; IPR000008; C2_dom.
DR   InterPro; IPR035892; C2_domain_sf.
DR   InterPro; IPR037722; C2C_Ferlin.
DR   InterPro; IPR037723; C2D_Ferlin.
DR   InterPro; IPR037725; C2F_Ferlin.
DR   InterPro; IPR012968; FerIin_dom.
DR   InterPro; IPR037721; Ferlin.
DR   InterPro; IPR032362; Ferlin_C.
DR   PANTHER; PTHR12546; FER-1-LIKE; 1.
DR   PANTHER; PTHR12546:SF60; MISFIRE, ISOFORM F; 1.
DR   Pfam; PF00168; C2; 4.
DR   Pfam; PF08151; FerI; 1.
DR   Pfam; PF16165; Ferlin_C; 2.
DR   SMART; SM00239; C2; 4.
DR   SMART; SM01202; FerI; 1.
DR   SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 5.
DR   PROSITE; PS50004; C2; 4.
PE   4: Predicted;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000079169};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        979..999
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        1452..1472
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          75..210
FT                   /note="C2"
FT                   /evidence="ECO:0000259|PROSITE:PS50004"
FT   DOMAIN          426..554
FT                   /note="C2"
FT                   /evidence="ECO:0000259|PROSITE:PS50004"
FT   DOMAIN          606..738
FT                   /note="C2"
FT                   /evidence="ECO:0000259|PROSITE:PS50004"
FT   DOMAIN          1207..1351
FT                   /note="C2"
FT                   /evidence="ECO:0000259|PROSITE:PS50004"
FT   REGION          794..824
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1014..1040
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1059..1145
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1070..1096
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|RefSeq:XP_026681577.1"
SQ   SEQUENCE   1483 AA;  169274 MW;  B06FBB96596F193C CRC64;
     VVHSKKILRT SKHVGSFKLD VSTVFAQPDH QFYHKWALLT DPDDIAGGPK GYLKCDISVI
     GKGDTVKIPQ KSEKDEDDIE ANLLLPEGVP LERQHARFII RIYRADGLPK MNSSLVANVK
     KAFTGETKDL VDPYVQVSFA GLTGKTSVKK NSYNPVWNEQ IIFSEMFPPL CSRIKIQLRD
     NDPVNNTVIG THYIDLKNIS NDGDKGFLPT FGPNFVHMYG STRDYSLLDE NYSLNTGLGE
     GVSYRARLLI AIRTEITDNI DIIPADVEVE STFPVVEHSY GKNEEFFLFG TILEATMIDK
     RLGEKPVYLE MSIGNAGNTL DGYNQPSQEH ADSDVEEPQL GKYFVFDFHM PAVMLFDKII
     TLSEHLGSMA RNLKALVTKH SFKERLKTSQ TYLLKLKDII EDKYVSMDLP PSVIHYSEKY
     ASMDLAPSVI HYSEKYSFQL RAYMYQARSL IGSDASGLSD PFARVVIGEY CKTTQVIDET
     LSPTWDETLV MDEILVYGTQ EEIQADPPVI IIEIFDQDKV GKSEFIGRAM AKPHVKLLSD
     PYTKPRFPPS LEWYPIHRGS ESAGELLATF ELFQLPPNNR SGAGDLPDLP DPKELYMVSQ
     QGPEQYIGPI LPVPEGIRPT LARYRIEVLF WGLRDLKRVH FMSVDKPRVD IECAGHILYS
     SVIQNAKKNP NFSNPVKFLE LELPEQELYR PPLTIRVVDC RSFGRFTLVG THMINSIHRY
     MYIPLTRRDK EEKTRAALTT QANNPGLQCN GFIDSSEKQK MDIHISATEK TPLLPGCNQD
     TIITMNYVNT GHGRGLSRQR SLKSNGKKRR KVSSDEMDDE DDDSRDWWSK YFASIEATIE
     GSIKVYKWPL PKDIEDHTIM GFDPQYGFFQ GVPNNDPIHV LVRVYVVKAT DLHPMDLNGK
     ADPYVVLQLG SKRLSDKENY VSKQLNPVFE EAEKNPAGQG RNEPDPLDKP NRPDASFMWF
     LNPLKSIRYI VWHNYKWRIL QTLLFCLLFF MILTFFYAVP GYTVKKLLGG GLSRQRSLKS
     NGKKRRKVSS DEMDDEDDDS RDWWSKYFAS IEATIEEGKE ARREKQLENH SSLSLSATPG
     LEDHHTTTSS GGGHLSSGRK FHSAAKLVSK LSPKSGRPTK NNGKMAKMKE CEGSPKSGRP
     TKNNGKMAKM KIYTSELENQ PEFNGFREWL LPFDLYRGKK TGDEEEDDNR VVGTFKVSQH
     LYSLGIQNPD NGYNRWRDPM KPTQILARLC KDAKMDQPQY TNGKVKIGKK TWLKGPEDCQ
     CTDIHYRSLT GEGNFNWRFV FPFDYLVAEE KIVISKKESL FSWDESESKI PARLELQVWD
     ADHFSADDFL GAITLDLNRF PRGAKSSKLC TLDMLRVEGN VPMVNIFKQK RVKGWWPFYV
     KKENEEMELT GKVEAEIHLL TQEEAEKNPA GQGRNEPDPL DKPNRPDASF MWFLNPLKSI
     RYIVWHNYKW RILQTLLFCL LFFMILTFFY AVPGYTVKKL LGA
//