ID A0A3Q0J8I5_DIACI Unreviewed; 1772 AA.
AC A0A3Q0J8I5;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 24-JAN-2024, entry version 21.
DE RecName: Full=adenylate cyclase {ECO:0000256|ARBA:ARBA00012201};
DE EC=4.6.1.1 {ECO:0000256|ARBA:ARBA00012201};
GN Name=LOC103516636 {ECO:0000313|RefSeq:XP_026684774.1};
OS Diaphorina citri (Asian citrus psyllid).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Paraneoptera; Hemiptera; Sternorrhyncha; Psylloidea; Liviidae;
OC Diaphorina.
OX NCBI_TaxID=121845 {ECO:0000313|Proteomes:UP000079169, ECO:0000313|RefSeq:XP_026684774.1};
RN [1] {ECO:0000313|RefSeq:XP_026684774.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP = 3',5'-cyclic AMP + diphosphate; Xref=Rhea:RHEA:15389,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:58165; EC=4.6.1.1;
CC Evidence={ECO:0000256|ARBA:ARBA00001593};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR RefSeq; XP_026684774.1; XM_026828973.1.
DR STRING; 121845.A0A3Q0J8I5; -.
DR PaxDb; 121845-A0A3Q0J8I5; -.
DR KEGG; dci:103516636; -.
DR OrthoDB; 3087296at2759; -.
DR Proteomes; UP000079169; Unplaced.
DR GO; GO:0005886; C:plasma membrane; IEA:InterPro.
DR GO; GO:0004016; F:adenylate cyclase activity; IEA:UniProtKB-EC.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006171; P:cAMP biosynthetic process; IEA:InterPro.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR CDD; cd07302; CHD; 1.
DR Gene3D; 3.30.70.1230; Nucleotide cyclase; 3.
DR InterPro; IPR001054; A/G_cyclase.
DR InterPro; IPR032628; AC_N.
DR InterPro; IPR009398; Adcy_conserved_dom.
DR InterPro; IPR029787; Nucleotide_cyclase.
DR PANTHER; PTHR45627; ADENYLATE CYCLASE TYPE 1; 1.
DR PANTHER; PTHR45627:SF1; ADENYLATE CYCLASE TYPE 8; 1.
DR Pfam; PF16214; AC_N; 1.
DR Pfam; PF06327; Adcy_cons_dom; 1.
DR Pfam; PF00211; Guanylate_cyc; 3.
DR SMART; SM00044; CYCc; 1.
DR SUPFAM; SSF55073; Nucleotide cyclase; 3.
DR PROSITE; PS50125; GUANYLATE_CYCLASE_2; 3.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Lyase {ECO:0000256|ARBA:ARBA00023239};
KW Magnesium {ECO:0000256|ARBA:ARBA00022842};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022840};
KW Reference proteome {ECO:0000313|Proteomes:UP000079169};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 44..65
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 77..97
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 104..122
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 134..153
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 165..187
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1243..1263
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1269..1289
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1301..1320
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 528..565
FT /note="Guanylate cyclase"
FT /evidence="ECO:0000259|PROSITE:PS50125"
FT DOMAIN 743..780
FT /note="Guanylate cyclase"
FT /evidence="ECO:0000259|PROSITE:PS50125"
FT DOMAIN 1379..1452
FT /note="Guanylate cyclase"
FT /evidence="ECO:0000259|PROSITE:PS50125"
FT REGION 1038..1124
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1567..1705
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1731..1772
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1061..1119
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1572..1614
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1631..1654
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1672..1702
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1772 AA; 202179 MW; 4BE9DD7EC0499554 CRC64;
MIPVFKKGVL YKGIYCPSLT NSFREPSLEM SYQRYSHRQR QKSLIIVNLV DMVLKAVLTV
AWISYNEVEL SQIDSTKLTW TVYTMMSNLA MCLLGWWRCF ANNYLQWAAV GTWILLNTQG
FISQGIGLNN KEYLIWYILF IVFVTYAMLP LPLKWCFIGG CTTSVLHVII TAQIKLLFIV
FVTYAMLPLP LKWCFIGGCT TSVLHVIITA QIKLHRGPLS PCSVHEMGAL CLVYIGINSA
GMYTKYLTDR GQRRAFLETH RSTETRMKTQ KENDQQEKLL LSGMIYIHCY EHVSILFADI
KGFTGEPLSS YQTPGRTIVF VSNFWVIATT VCLVFPRLSG TGKRKQIAQM ILNPDDHNLL
LCSSCNTDFT NNIEYNNTQQ ILNPDDHNLL LCSSCNTDFT NNIEYNNTQQ VLSLRHRRSI
SDGKHEDIRF LLPNNEHETM RTNDLRADAI NKHNTERNDL AKTSVAFERD IKNYKPISIS
LDDKEVSGNV ASSYARGDNS GIQQNGKSLL LRLKEKLKPN EGKLNVDLNM RIGIHSGSVL
CGVLGLRKWQ FDVWSYDVTL ANHLEAGGIP GRVHISRATL DCLQEMYEVE PGYGDTRDSY
LKEHQVETFL IKSQEPTKIR RGRFHTMISR SRLWSEDSGA QQDSRNSVSS QASSQSVINK
DSLNLLSNNQ SLGYIDEEIN HLNWTPEIPF ENVSLLNKDS LNLLSNNQSL GYIDEEINHL
NWTPEIPFEN FHRIYIHCYE HVSILFVDIK GFTEWASQCS AQELVRVLND LFAKFDRLAA
VDLTNSTRPS QIPTTKVNDI LDQCIEIDNN EKLRKENINR WTLRFKQTDM EEKLSSTGPD
HVANHFLAQD RQTEVVSFST ATLLNSTRPS QIPTTKVNDI LDQCIEIDNN EKLRKENINR
WTLRFKQTDM EEKVCLPFRM RKENINRWTL RFKQTDMEEK EMYEVEPGYG DTRDSYLKRS
KTLSGSDLVN NRIDKLFNVQ SDIDVTDCDD ASPIKTSDVV LNRFSREATC DDASPIKTSD
VVLNRFSREV KHYPRDVKVD RRRGRTRTLR HSGTNSKVTD GEDLADIKRG DEQLKENEGD
KESVSDGRNE DVREFDETNK DIDEPNENLK DIFETNDDVK ESELNEDIGE FGEPKEDIKD
IIDEVNGDIK EFGKRKESLG EIDGTNKDVK LFDKTNASGI NNKITQIGGD TIKDIVRTRR
NTDMDQKQES DQYTSGLLML ADYFNSSTRE VPKLLDKCVH PEWLVFTWVL CLVALATTLK
LYFVVKALLA VLMVTMYGLL ILVFYPDIFK QGYDKELQMP LMSPMLLLLA VFLILVAYHA
RLVEITSRLD FLYKREAERE LSEMRETRSN NRQLLRNILP DHVANHFLAQ DRQTEVMDFD
ELLSEPRFRS IEKIKTVGAC YMAASGLDPK HHSHLDELDH VCALIDFSLA IKQCLDQVNK
HSFNHFFLRV GFTRHPSQHN SLAAVVYGMV QARRRKNTIK RPSPQLLGQA STYHTGFTRH
PSQHNSLAAV VYGMVQARRR KNTIKRPSPQ LLGQASTYHT GFTRHPSQHN SLAAVVYGMV
QARRRKNTIK RPSQGGGLSR TKSQHHASTS SGNIRHPLHN DSTSSPNFQH FLSHSPDPSD
PPCPGSEPTP SGRRINFSSF RIHNRNSPGL GFRRNTTRHR TKPSGEIGNL DSIRRKSPRR
DEAKRSPEGK AMLPEARTSA EDSDRNLSIS GIDSLISKSS GDRNLTIGGI DSSLSISNNR
SAPQTPQARS GPHRSISMNF QSHSNVHLND LR
//