ID A0A3Q0KB95_SCHMA Unreviewed; 2483 AA.
AC A0A3Q0KB95;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=Filamin {ECO:0000313|WBParaSite:Smp_000100.1};
OS Schistosoma mansoni (Blood fluke).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Trematoda;
OC Digenea; Strigeidida; Schistosomatoidea; Schistosomatidae; Schistosoma.
OX NCBI_TaxID=6183 {ECO:0000313|Proteomes:UP000008854, ECO:0000313|WBParaSite:Smp_000100.1};
RN [1] {ECO:0000313|Proteomes:UP000008854}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Puerto Rican {ECO:0000313|Proteomes:UP000008854};
RX PubMed=22253936; DOI=10.1371/journal.pntd.0001455;
RA Protasio A.V., Tsai I.J., Babbage A., Nichol S., Hunt M., Aslett M.A.,
RA De Silva N., Velarde G.S., Anderson T.J., Clark R.C., Davidson C.,
RA Dillon G.P., Holroyd N.E., LoVerde P.T., Lloyd C., McQuillan J.,
RA Oliveira G., Otto T.D., Parker-Manuel S.J., Quail M.A., Wilson R.A.,
RA Zerlotini A., Dunne D.W., Berriman M.;
RT "A systematically improved high quality genome and transcriptome of the
RT human blood fluke Schistosoma mansoni.";
RL PLoS Negl. Trop. Dis. 6:E1455-E1455(2012).
RN [2] {ECO:0000313|WBParaSite:Smp_000100.1}
RP IDENTIFICATION.
RC STRAIN=Puerto Rican {ECO:0000313|WBParaSite:Smp_000100.1};
RG WormBaseParasite;
RL Submitted (DEC-2018) to UniProtKB.
CC -!- SIMILARITY: Belongs to the filamin family.
CC {ECO:0000256|ARBA:ARBA00009238}.
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DR AlphaFoldDB; A0A3Q0KB95; -.
DR STRING; 6183.A0A3Q0KB95; -.
DR EnsemblMetazoa; Smp_000100.1; Smp_000100.1; Smp_000100.
DR WBParaSite; Smp_000100.1; Smp_000100.1; Smp_000100.
DR InParanoid; A0A3Q0KB95; -.
DR Proteomes; UP000008854; Unassembled WGS sequence.
DR ExpressionAtlas; A0A3Q0KB95; baseline.
DR GO; GO:0043232; C:intracellular non-membrane-bounded organelle; IEA:UniProt.
DR GO; GO:0051015; F:actin filament binding; IEA:InterPro.
DR GO; GO:0030036; P:actin cytoskeleton organization; IEA:InterPro.
DR CDD; cd21311; CH_dFLNA-like_rpt1; 1.
DR Gene3D; 1.10.418.10; Calponin-like domain; 2.
DR Gene3D; 2.60.40.10; Immunoglobulins; 22.
DR InterPro; IPR001589; Actinin_actin-bd_CS.
DR InterPro; IPR001715; CH_dom.
DR InterPro; IPR036872; CH_dom_sf.
DR InterPro; IPR044801; Filamin.
DR InterPro; IPR017868; Filamin/ABP280_repeat-like.
DR InterPro; IPR001298; Filamin/ABP280_rpt.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR014756; Ig_E-set.
DR PANTHER; PTHR38537:SF18; FILAMIN-A; 1.
DR PANTHER; PTHR38537; JITTERBUG, ISOFORM N; 1.
DR Pfam; PF00307; CH; 2.
DR Pfam; PF00630; Filamin; 22.
DR SMART; SM00033; CH; 2.
DR SMART; SM00557; IG_FLMN; 22.
DR SUPFAM; SSF47576; Calponin-homology domain, CH-domain; 1.
DR SUPFAM; SSF81296; E set domains; 22.
DR PROSITE; PS00019; ACTININ_1; 1.
DR PROSITE; PS00020; ACTININ_2; 1.
DR PROSITE; PS50021; CH; 2.
DR PROSITE; PS50194; FILAMIN_REPEAT; 22.
PE 3: Inferred from homology;
KW Actin-binding {ECO:0000256|ARBA:ARBA00023203};
KW Reference proteome {ECO:0000313|Proteomes:UP000008854};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 33..139
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT DOMAIN 156..259
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT REPEAT 266..364
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 366..464
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 499..595
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 595..686
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 690..787
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 788..883
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 884..981
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 1007..1099
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 1104..1203
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 1204..1296
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 1297..1395
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 1396..1495
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 1496..1590
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 1627..1697
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 1697..1789
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 1789..1875
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 1878..1970
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 1988..2068
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 2071..2163
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 2186..2264
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 2264..2356
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 2388..2482
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REGION 483..509
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 914..933
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2483 AA; 268348 MW; 6DED1AE38E081BBF CRC64;
MDYPDPDAGY VDEDEEEIPM AERELAEDAE WKLIQKNTFT RWANEHLKPK NVTVDDLQFD
LADGLRLIAL VESLSGQQFK HVNRKPSFRT QKLENVTMVL RFLEENEGLR LVNIDSSDIV
DCRSKLILGL IWTLILHYSI TIPLWEGEPD FGAQGPTPKQ RLLSWLNNKL ADRPVKNFTT
DWNDGIAIGA LVDACAPGLC PDWREWEPKQ NLRNAREAMG AAEQWLDVPQ LIHPEEMTNP
RVDEKAMMTY LSQFPSAKLK DGAPLRPKSN PGLVRAYGPG LEPHGNTVGN PARFTIDTFS
AGRGAVEVIV LNPKGQREPC DVLSNNDKQQ TYSCAYVPTQ EGEYRVIIKF ATKEILNSPF
KVMVEGAQGD GSKATASGPG IEPTGNQVGR RTFFNIFTAA AGPGNADCVI LDPHGRRDSI
KPLITRQGED NYLVEYTPKD EGLHSVNVFY AGQQISNSPF GVMVGPRPPP VVQSPAPIVN
QEAPLQATQS PRKMSQPQRP ACDPKQAYAT GRGIQPQGIR VKDLADFKVH TEDAGEGPLE
VSVIAPDGRG IPCTSRKTGA YLFDCSYTPQ RPGTHQVNVR YGGDHIMLSP FTVEVAPYKE
SRIRAFGPGL VGGVVNKPAV FVVETNGETG ALGFSIEGPS EARIDCTDNG DGSATVAYWP
TAPGEYAVHI LCNDENIPKS PFMVPIEPDM GKCDPERVKA HGPGIMPTGN VAGQPTEFTV
DIRDSGGPAP LTVECRDNEG EPVALKVRDN GDGTYTCSYT PKVPKKHTVL VSYGGVNIPR
SPFRVEVAEP SNPGKVRVFG PGVENVTRGQ PTYFTVDCKQ AGHGNVGISV TDEAGRDVAM
DTQDMRDGTF KVAYTANTPG PYYTVQVFFN NQEVPRSPFK VPVKPNIDMS KIHVENLEPN
ITTGVPTEFD VITAGAGPPN NSKPKPTVTV KSPNGMRVPC TLAESVDGYT PSFTPTVVGP
HTVAVEVGGV PVKGSPFRTN AIPPAAVQEP IYPKDFGRQQ ATSAPISGPE AAALVRAYGD
GLYRATAGKQ AKFTIDSQDA PPAPLSVTIE GPAEAKINYN DNGDGTCGVD YLPTEPGPYI
VNVLYKDTHI KGSPFPVRVA PLGREHIDVS RVHAYGPGLQ PTGVFKESFA KFTVDAKAVD
PQSRGIVKAI VVSPNKQRTA CLIQNNGDGT YKCSYSPIDD GLHHVEVTYD GAPVPGSPFP
VNVAPGCDPT RVRAYGPGLE GGFTHEPQRF TVDLDGAGQG ALGLALEGPA DAQIQCQDNK
DGTCTVDYLP TRAGTYDIFV KFNDMNIPGS PFQVPIRDVV DPTRVRCYGP GLEPRGARAQ
QPAHFTVDAS QAGDAPIQVA TVDRVGRTAP AHVVPRPNQP GVYDVTYVPD TDGPCQIEVK
QAGNHVARSP FTQHVLPAFE PQRVRVTGEG VHPTRPLGLP ATQPTSFQVD TRDAGLGDLE
LSVMDPDGQP LQLEVVDVGD GTYVCHYTPM IVGRHTVRVK YGGQEIPESP FLVPVAPSGR
SNMCRIENGN DSRIPVGQEC VISVNTQQAG VGQLTCRIVT PSGATADVEI HEAPNGRVNI
YYTPPIRGDY LVEIRFGGEL IPNGRFNQKA VSPEELMNDV TDQRVQHVTV QSVQSVQSST
VTTGYHPVDF KLPVGPTFSH VEGLVRTPSG RILHPTLLDN GDGTVTAQFQ PNEPGLHELE
ITYNGQPIPG SPFRFYVEAV GSGIVTAYGP GLSCGRAGEP SNFTLITRDA GAGGLSLSVE
GPSKADIQCD DNKNGTCSVS YLPLVPGEYT ISIKFMENHI PGSPFTAHIA GESRRFNQVC
VGTTSEMPLR ITETDIYNLV ATVRSPSGHE QPSTLKRLPN GHLGISFTPH EIGEHFVNVF
RNGRHIANSP FKIYVGENEI GNASKVRIYG NGLREGMANQ NCQFTVDTRN AGYGGLNLSI
EGPSKADIEC HDNQDGTCLV TYRPTEPGTY IINVKYAEQP VPGSPFVVHI GGEPSLRMME
RITRQRELAD ATYVGSQCEL NLKIPGINIR DLTANVTSPS GVSQRCDVLA MDDVNYTIKF
VPQEMGVHTV SVRHRGSHIS GSPFQFTVGP ITEGGAHKVH ATGQGLQNGL TYSLNDFSIY
TREAGAGGLS IAIEGPSKAE INFEDRKDGS CGVSYRVTEP GEYLCSIRFN DDHIPNSPFR
VIINEAMERT FYTPETKLLN ITSIQDRGLS VGRPTAFTVN YSGMTGRMRA YVVAPSGIQS
DAFVHQVDVD QHAVRFTPHE NGAHLVHVLM DERPVPGSPF RVLVGQEETG HVTASGEGLT
HGRVGERNRF FVNTVQAGSG ALSVTVDGPS KVQLNCTERS DGYDFTYLPL SPGEYLISIK
YGDSQHIIGS PYKAIVTGDA VHETITTDTT HVVVETGGRM VNGPHSNFGP SRPDRVTCSG
PGLKQAYLNE ANTFTVNASQ AGHDVLYVGV SGPVVACEEV NIKHMGYGQY SISYTVRDRG
RHLIMIKWGD QHVPGSPFTV DVI
//
