ID   A0A3Q0KBW6_SCHMA        Unreviewed;       789 AA.
AC   A0A3Q0KBW6;
DT   13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT   13-SEP-2023, sequence version 2.
DT   27-MAR-2024, entry version 22.
DE   SubName: Full=Putative sex comb on midleg homolog {ECO:0000313|WBParaSite:Smp_006250.1};
OS   Schistosoma mansoni (Blood fluke).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Trematoda;
OC   Digenea; Strigeidida; Schistosomatoidea; Schistosomatidae; Schistosoma.
OX   NCBI_TaxID=6183 {ECO:0000313|Proteomes:UP000008854, ECO:0000313|WBParaSite:Smp_006250.1};
RN   [1] {ECO:0000313|Proteomes:UP000008854}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Puerto Rican {ECO:0000313|Proteomes:UP000008854};
RX   PubMed=22253936; DOI=10.1371/journal.pntd.0001455;
RA   Protasio A.V., Tsai I.J., Babbage A., Nichol S., Hunt M., Aslett M.A.,
RA   De Silva N., Velarde G.S., Anderson T.J., Clark R.C., Davidson C.,
RA   Dillon G.P., Holroyd N.E., LoVerde P.T., Lloyd C., McQuillan J.,
RA   Oliveira G., Otto T.D., Parker-Manuel S.J., Quail M.A., Wilson R.A.,
RA   Zerlotini A., Dunne D.W., Berriman M.;
RT   "A systematically improved high quality genome and transcriptome of the
RT   human blood fluke Schistosoma mansoni.";
RL   PLoS Negl. Trop. Dis. 6:E1455-E1455(2012).
RN   [2] {ECO:0000313|WBParaSite:Smp_006250.1}
RP   IDENTIFICATION.
RC   STRAIN=Puerto Rican {ECO:0000313|WBParaSite:Smp_006250.1};
RG   WormBaseParasite;
RL   Submitted (DEC-2018) to UniProtKB.
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DR   RefSeq; XP_018654106.1; XM_018788577.1.
DR   AlphaFoldDB; A0A3Q0KBW6; -.
DR   STRING; 6183.A0A3Q0KBW6; -.
DR   EnsemblMetazoa; Smp_006250.1; Smp_006250.1; Smp_006250.
DR   GeneID; 8352324; -.
DR   KEGG; smm:Smp_006250.1; -.
DR   WBParaSite; Smp_006250.1; Smp_006250.1; Smp_006250.
DR   InParanoid; A0A3Q0KBW6; -.
DR   Proteomes; UP000008854; Unassembled WGS sequence.
DR   ExpressionAtlas; A0A3Q0KBW6; baseline.
DR   GO; GO:0005634; C:nucleus; IEA:InterPro.
DR   GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR   CDD; cd20092; MBT_dScm-like_rpt2; 1.
DR   CDD; cd09509; SAM_Polycomb; 1.
DR   Gene3D; 2.30.30.140; -; 2.
DR   Gene3D; 1.10.150.50; Transcription Factor, Ets-1; 1.
DR   InterPro; IPR004092; Mbt.
DR   InterPro; IPR001660; SAM.
DR   InterPro; IPR013761; SAM/pointed_sf.
DR   PANTHER; PTHR12247; POLYCOMB GROUP PROTEIN; 1.
DR   PANTHER; PTHR12247:SF132; POLYCOMB PROTEIN SCM; 1.
DR   Pfam; PF02820; MBT; 2.
DR   Pfam; PF00536; SAM_1; 1.
DR   SMART; SM00561; MBT; 2.
DR   SMART; SM00454; SAM; 1.
DR   SUPFAM; SSF47769; SAM/Pointed domain; 1.
DR   SUPFAM; SSF63748; Tudor/PWWP/MBT; 3.
DR   PROSITE; PS51079; MBT; 1.
DR   PROSITE; PS50105; SAM_DOMAIN; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000008854};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT   REPEAT          165..266
FT                   /note="MBT"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00459"
FT   DOMAIN          722..787
FT                   /note="SAM"
FT                   /evidence="ECO:0000259|PROSITE:PS50105"
FT   REGION          341..380
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        355..380
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   789 AA;  88792 MW;  CB201B4F56EAD440 CRC64;
     MGCHVSADSS NSFTWDDYLK KTNGRPAKLE CFKQSLVPPP NYFEVNTILE AEDQRSAALV
     LNPYSNDLIK ARYANNSTSS NQQLLETPCR RSSLNPHSSG TVRRFRAASF SLARVIETCG
     PRLRIRLVGT DDRNDYWFLV DSDQIRPYPS GSPLQPPFGY MHNHLVWNRT LKKATEGTRF
     ADPSWFISQP PDPEDNYFQV NDKLEAVDRR NTQLICPASV GAVNGHHILI NFDGWSGAFD
     YWARFDSREL FPVGWCKSAN YPLQPPGPNV IRSPIIHSTP SFLYAHNSVS QAPSVSPKYL
     SKVLTNSCSR ISKTDKTSSC PRKKLGLSRR IKSHANLVRS NLRDETESST HFRNPRELST
     KQPLSMSPFS PALSKPNHNS VASEHMDVNK NERVDLFVEP NSLNTSQVDS SIQSLTSPPI
     VPPVLEDASD SLNTFYSSSP PEHPPRIEAS EFVRDSADGR HRRFSSPSDC VVRLQAKSSL
     MPVSNVLHPY EPELKSWKVV TKTKQKNKQH KLKRRSGNSK KKCPEIKQKF KIANDSLTNS
     VLCDYEYVDS VSPQLKGFSD MSQNYEKSIA YPEDNPNLYK NETANSTAFC KNDSSLTCTP
     VFMADRKSLF KSENDRTNGS TMGSSLVFQS HISHDIMHTN GCYFDEMNSP THDNLSVETS
     DSHLWFSGKL ESNSNKSTYP VYAHQNVDSL DSQSLTTHLP SSTVSPSSLD LGSFPFPNPT
     QWTIEEVYNY ITARDATLLE AAEKFKHHEI DGQALLLLSM ESLRNYMKIK LGPALKMVHL
     ISRLKRGLL
//