ID A0A3Q0KC77_SCHMA Unreviewed; 1724 AA.
AC A0A3Q0KC77;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE RecName: Full=receptor protein-tyrosine kinase {ECO:0000256|ARBA:ARBA00011902};
DE EC=2.7.10.1 {ECO:0000256|ARBA:ARBA00011902};
OS Schistosoma mansoni (Blood fluke).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Trematoda;
OC Digenea; Strigeidida; Schistosomatoidea; Schistosomatidae; Schistosoma.
OX NCBI_TaxID=6183 {ECO:0000313|Proteomes:UP000008854, ECO:0000313|WBParaSite:Smp_009990.1};
RN [1] {ECO:0000313|Proteomes:UP000008854}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Puerto Rican {ECO:0000313|Proteomes:UP000008854};
RX PubMed=22253936; DOI=10.1371/journal.pntd.0001455;
RA Protasio A.V., Tsai I.J., Babbage A., Nichol S., Hunt M., Aslett M.A.,
RA De Silva N., Velarde G.S., Anderson T.J., Clark R.C., Davidson C.,
RA Dillon G.P., Holroyd N.E., LoVerde P.T., Lloyd C., McQuillan J.,
RA Oliveira G., Otto T.D., Parker-Manuel S.J., Quail M.A., Wilson R.A.,
RA Zerlotini A., Dunne D.W., Berriman M.;
RT "A systematically improved high quality genome and transcriptome of the
RT human blood fluke Schistosoma mansoni.";
RL PLoS Negl. Trop. Dis. 6:E1455-E1455(2012).
RN [2] {ECO:0000313|WBParaSite:Smp_009990.1}
RP IDENTIFICATION.
RC STRAIN=Puerto Rican {ECO:0000313|WBParaSite:Smp_009990.1};
RG WormBaseParasite;
RL Submitted (DEC-2018) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-
CC [protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA-
CC COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858,
CC ChEBI:CHEBI:82620, ChEBI:CHEBI:456216; EC=2.7.10.1;
CC Evidence={ECO:0000256|ARBA:ARBA00001171};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
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DR AlphaFoldDB; A0A3Q0KC77; -.
DR STRING; 6183.A0A3Q0KC77; -.
DR EnsemblMetazoa; Smp_009990.1; Smp_009990.1; Smp_009990.
DR WBParaSite; Smp_009990.1; Smp_009990.1; Smp_009990.
DR InParanoid; A0A3Q0KC77; -.
DR Proteomes; UP000008854; Unassembled WGS sequence.
DR ExpressionAtlas; A0A3Q0KC77; baseline.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004714; F:transmembrane receptor protein tyrosine kinase activity; IEA:UniProtKB-EC.
DR CDD; cd00063; FN3; 2.
DR CDD; cd00064; FU; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 3.
DR Gene3D; 3.80.20.20; Receptor L-domain; 2.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR006211; Furin-like_Cys-rich_dom.
DR InterPro; IPR006212; Furin_repeat.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR017441; Protein_kinase_ATP_BS.
DR InterPro; IPR000494; Rcpt_L-dom.
DR InterPro; IPR036941; Rcpt_L-dom_sf.
DR InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR PANTHER; PTHR24416:SF617; RECEPTOR PROTEIN-TYROSINE KINASE; 1.
DR PANTHER; PTHR24416; TYROSINE-PROTEIN KINASE RECEPTOR; 1.
DR Pfam; PF00757; Furin-like; 1.
DR Pfam; PF07714; PK_Tyr_Ser-Thr; 2.
DR Pfam; PF01030; Recep_L_domain; 1.
DR PRINTS; PR00109; TYRKINASE.
DR SMART; SM00060; FN3; 2.
DR SMART; SM00261; FU; 1.
DR SUPFAM; SSF49265; Fibronectin type III; 2.
DR SUPFAM; SSF57184; Growth factor receptor domain; 1.
DR SUPFAM; SSF52058; L domain-like; 2.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS50853; FN3; 1.
DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU10141}; Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Kinase {ECO:0000256|ARBA:ARBA00022777};
KW Membrane {ECO:0000256|ARBA:ARBA00022989};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU10141}; Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000008854};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022989};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT SIGNAL 1..30
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 31..1724
FT /note="receptor protein-tyrosine kinase"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5018255507"
FT DOMAIN 686..782
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1165..1539
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT BINDING 1192
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10141"
SQ SEQUENCE 1724 AA; 194297 MW; 10913076F75E8483 CRC64;
MHSLIHYRIN VFTFLFYFLV QHITTYPSSS KEIVCTRADI RHPSSLTRLL RCTVIEGDLF
VVFTRIPRDA SLPFLREITG SLLVYDVEGP DDLSNLLPNL TLIRGQTLVF GYAVVIKSTS
LKNIGLFSLR VIQQGGVRID SNPQLCYVRT IDWDVILQGQ NGDVSSVKIV KNGLCPNTCS
SGCSVASQST GRLSAIGLWS PLLRDISPTD GHCWSMNECQ SICPLNCTLL NLTCTMKRPH
KCCHPECLAG CYGDGPSMCV ACKNVMHENR CVSQCPGGTF KYLNRRCVTE YQCLTQFPNL
TYADLPNMSD HHANSFSNHS FPRDIMAKID SDFTIFNGSC LSNCPVGYKK SSKTGLCYPC
GDQCELKHCR EFLIHSLKVL DTLAGCYSAK AIYLSIQEGQ PEIVALLLDR AFANLRVIHH
SLRIVRSSVL NNLNFLRHVR SIGQIGGNIS NHPIVFELFG NDNLRDLWSV TNDANNNDDG
LQILSNGLIR ITQNRQLCPE KIFELFDSNK IKLEGNNITL TQAEREMITI TNGDLAYCNW
RKFDIKLSGL SSHSVRVIWP YPSTIQFADT SMNANFSHGL NSSYVDELVL MYLFYQPAPK
DIPNIVKDRR AYDKNSWRML TASCDSNPGD NIPELPHLEL YCGLTLFKLE SATRYVVYVE
MKFPLKRTGA VSNLVYFTTL SINPSPPQYP WLEPVNKNSL RLTWMPPAKP SGIIDTYLIW
IRILEDNPSD YLTQDFCIHK PNWIHSGWDT NLPIRHTDHI NFERGYCDSC SSCPNLHEIE
QLSNIQTISS SNENYWPSSV SRWMTDDSGN LLPVNIVDEN FSLKSGTVGL IVQKNFSTYF
KDISYFQTNP QKTCIQSVNE NVKYLTGLSP FTRVLVEIQA CLEYDSISHE KPLKAKCNYP
PPWFNKKSGI IVHLDQLQHQ WAACEYELCS PRSTVINRVN PHVESDNIPV SSIYASSNGP
GSIRITWSSP IKPNGLIIHY ILRYRPRNHD SHTDNYSFSD MSVPWLTNCV SLSHWATVKP
EQKSLTSSLF TDFNKKIVSR SERGSNGDSN TTKGGILIKD LSPGSYEFQI LAISLAGRGE
WSPTEIFNIP FYTDYNGIVN QRKLANICTI TVGAFSLLCF IFGIIWYKAR RYYLKVTAWT
SNNPDYCTIY EVDDWEITKD DVDVLHWKYP IGRGSFGTVY KGVVKQLKTP AKLFYNNPRN
IPVAIKTISM HSTLFDHRDF INEACFMKQF QSYHLVRLLG LVTKTKHKHK SVTFTDRCIN
LLHQYHFGKL CLFVSRILKW TSTLPLLSSS SSSPNVKQSY LLSSSISPSL RKQMLDGEDL
NCHTLGLSKQ QFTNSDDTSL FNNIQSIGLM NKVAPESPLV IMQLMAKGDL ASYLRYLGDK
GQGSVNSSQA YLWATQIADG MAYLSAKQYV HSLTVKIGDF GLCRDVYGHN YYHKTSHAKL
PIRWMAPESL QTAYFTTQSD VWSYGVVLWE IVTMACLPYR GMSHEEVVKY VLSGKTLLSN
GSPTNCPELF RALMLHCWNF NPLKRPTFLG LCALLSPCFG DAKFRLASFF YHGEQSFVNR
DNRSKVLEAP AVSLGKLNIS CNQDPAHALA SALSTLFCGT DEDSSYDYSD RNIDPPDDFS
APSMQFGAIS RTATVNESSI GSGHFSETRL VNCSSEDVSL KQNDNGIALS EVQCLLRLCE
PDSNLAVPAF VDSESFPLIS NHIMKFDTDE CTNFELSRTR NVIA
//
