ID A0A3Q0KGA4_SCHMA Unreviewed; 3149 AA.
AC A0A3Q0KGA4;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=Histone-lysine N-methyltransferase 2C {ECO:0000313|WBParaSite:Smp_056930.1};
OS Schistosoma mansoni (Blood fluke).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Trematoda;
OC Digenea; Strigeidida; Schistosomatoidea; Schistosomatidae; Schistosoma.
OX NCBI_TaxID=6183 {ECO:0000313|Proteomes:UP000008854, ECO:0000313|WBParaSite:Smp_056930.1};
RN [1] {ECO:0000313|Proteomes:UP000008854}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Puerto Rican {ECO:0000313|Proteomes:UP000008854};
RX PubMed=22253936; DOI=10.1371/journal.pntd.0001455;
RA Protasio A.V., Tsai I.J., Babbage A., Nichol S., Hunt M., Aslett M.A.,
RA De Silva N., Velarde G.S., Anderson T.J., Clark R.C., Davidson C.,
RA Dillon G.P., Holroyd N.E., LoVerde P.T., Lloyd C., McQuillan J.,
RA Oliveira G., Otto T.D., Parker-Manuel S.J., Quail M.A., Wilson R.A.,
RA Zerlotini A., Dunne D.W., Berriman M.;
RT "A systematically improved high quality genome and transcriptome of the
RT human blood fluke Schistosoma mansoni.";
RL PLoS Negl. Trop. Dis. 6:E1455-E1455(2012).
RN [2] {ECO:0000313|WBParaSite:Smp_056930.1}
RP IDENTIFICATION.
RC STRAIN=Puerto Rican {ECO:0000313|WBParaSite:Smp_056930.1};
RG WormBaseParasite;
RL Submitted (DEC-2018) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR STRING; 6183.A0A3Q0KGA4; -.
DR EnsemblMetazoa; Smp_056930.1; Smp_056930.1; Smp_056930.
DR WBParaSite; Smp_056930.1; Smp_056930.1; Smp_056930.
DR InParanoid; A0A3Q0KGA4; -.
DR Proteomes; UP000008854; Unassembled WGS sequence.
DR ExpressionAtlas; A0A3Q0KGA4; differential.
DR GO; GO:0005654; C:nucleoplasm; IEA:UniProt.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd21997; HMG_KMT2C-like; 1.
DR CDD; cd15509; PHD1_KMT2C_like; 1.
DR CDD; cd15510; PHD2_KMT2C_like; 1.
DR CDD; cd15512; PHD4_KMT2C_like; 1.
DR CDD; cd15513; PHD5_KMT2C_like; 1.
DR CDD; cd15514; PHD6_KMT2C_like; 1.
DR Gene3D; 2.30.30.1150; -; 1.
DR Gene3D; 1.10.30.10; High mobility group box domain; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 5.
DR InterPro; IPR034732; EPHD.
DR InterPro; IPR036910; HMG_box_dom_sf.
DR InterPro; IPR011011; Znf_FYVE_PHD.
DR InterPro; IPR001965; Znf_PHD.
DR InterPro; IPR019787; Znf_PHD-finger.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR45888; HL01030P-RELATED; 1.
DR Pfam; PF00628; PHD; 4.
DR Pfam; PF13771; zf-HC5HC2H; 1.
DR SMART; SM00249; PHD; 6.
DR SMART; SM00184; RING; 5.
DR SUPFAM; SSF57903; FYVE/PHD zinc finger; 5.
DR PROSITE; PS51805; EPHD; 1.
DR PROSITE; PS50016; ZF_PHD_2; 5.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000008854};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00146}.
FT DOMAIN 183..300
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS51805"
FT DOMAIN 310..362
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS50016"
FT DOMAIN 359..409
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS50016"
FT DOMAIN 769..821
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS50016"
FT DOMAIN 818..868
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS50016"
FT DOMAIN 895..950
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS50016"
FT REGION 542..581
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 603..746
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1050..1172
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1195..1215
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1297..1347
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1585..1613
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1815..1836
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1863..1883
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1960..1988
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2347..2402
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2465..2666
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2735..2762
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2799..2888
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 542..574
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 603..637
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 645..730
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1058..1078
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1110..1164
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1198..1215
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1297..1320
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1321..1347
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1863..1881
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2465..2484
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2485..2499
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2500..2517
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2559..2666
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2735..2761
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3149 AA; 343608 MW; EE958F29A4E76C5A CRC64;
MGFEGSEYED DPLKDSTSDV QNPELLYTKV LSSFHPDESK TLQNFSDVTP PLCIFCGMNG
NLNLGQGELL RFYTKIEYSE PPTWYSDLII KVKLKQEKCT NILVTNRSTH TNRRNQHSKI
VVASFTPLTA DPEFCKVGPH TSLDGCRRSR SKNCFGYDCK MYLAGMPNAY FDCNGRPFGL
VEELNYVGWP SKPDEDTLKV SNLIVKCTPR EGEEGGWIYA HHCCASWSDG VHFNDQMVLE
GVEDAAVIAV TRKCSLCLRY GASISCRISD CDSCFHFLCA AGAGCLQDIE SLELLCPVHI
SEALASNCTS IQCGLCESPG DLTELLFCTG CGSHYHASCL EPPLQPSPTI RIGWQCAECK
TCLICNESKD ENKMLVCDVC DKGYHTYCLK PPVSSIPKNG FRCERCRVCS DCGGGRSSTL
SGLEGPVAFN NQLNPNVRWH SNYTLCDRCF HAHKRPNSCC PVCERAWRCS LPVPENFYRN
PNSTFLVWPG SRCSQCRRMV HAECDPSSNQ ATVSPLSAAS EETSGICGTN YVCPVCRARG
STTPSEAAST TASLRASPIQ GGGNSSNSGG DIMDDNFTQG GRDLLDDTVR QCIGSGSLVC
PGANGSTSAN TPSSSTSNST TPNTEPGKQQ IHLNNQDYPG SPRVHCKVTS NNKLSVTNST
SGRPAIDQPS INISSGRRRG NTQTSDLNFT KTNSGTRSNN ANTQTSFIGT TKTGALKRTN
SSATSNNINK TRRTKTRKIT SYESKVSEKD DHPSTVVFCR ADDNFMLEQD ICIACGSIGL
DTPLLACSQC GQCYHSFCAE VPKITRTMIE KGWRCLDCTV CEGCGGTSNE SLLLLCDDCN
ISFHTYCLDP PLKEVPKGGW KCTDCVICTN CGQKDPGLNG KWHANYSVCA PCASLTTCPI
CNLAYREEEL LVRCALCTRW AHANCDQLRT EDELEIATDL GYNCLLCREL GADIGTGHAQ
VLAYRQAANG NLGALENLKF GEITENLFAD KLPSSLFPYS STGVASLARS QADDDNNSSS
DTRQFFMDGV VLSECGLNTI KQALLKIQPK RHTNQKRLSD QQSQSVTDTG SCSVGDSTPV
ELTPCGPHGQ FDEDASLHSG VDGENDLSNY PDWKSPSLQS EEDGCNSMQD GTRTSLCISR
NSSAGSVSAN GKTTTNNSNR NRPLKNLGIG GFRAKPNRWL QTKKIQLAAA SDHFVGPLTS
DNKRRRQNKK KSELEDHYPN YLMKAFYGAC LLSAKRKPLR KKKRIRPISS SQELIVGPES
VSGIKQNKGG LTLSVRSSKP TKGGALMKKC DVARLGNRPK SDDYSLDGEW TESGSRDEEF
EIGTEEIDED DDIDEGDEEY EEDDDVDGDL CDFDELKDLE DEMDNEAFDI EEEDLSATLN
PAAHQLTERV SEIKMSEGST DSDILKTQKD NAENVSVDEC VSRELSAVDY NDNQAMSSRT
CPPVNSNSQD NYRLTSVSVS QLSPKSQNLV NSLDPSVDTV SAEAARVSNV VHSSNKELGP
HIDLLSAQSP QEQSTELSVT TSLVGQNANS ATQATTPAGL NEAADLMFMD DYLFGFGDLA
STDETDLNDI TPQQVSADHV TDQLQAPSPL SVGHSKNQLK QPVSSESPSH VSSIYSQNNQ
NIQSSERFVI SNKIVYQSQV SEPLRMEETT NSEGMCLKQF VAQQDLISSP FDNQSQPAHL
GSATKPHYQK SPYLGHSSTT YLQIVEDQHS RNMQRTVPLE SQQSHLVIQD QQTHKTGPQS
VHDSSEGSLN QLVDTVDVCP PNNTILNAYD MPPRDTSGHD LGSSQSVPGP HPRHCVNTLT
GNLPELSVSD IETQLGPSTG FELSEPNLAD DSPKSIIPNA VFSNELSTTP PPSEISIQRM
AQQRQNVVHP NPDSVRQSYS QRPVDHCREY QPSNQSINVQ QHQIPRSSLV TVPIPQSQVR
PMQQQHIDPQ SGRVQIRSSQ PSYFYAHVVP VPGRVLTQPQ KQHQQLQRQS SSPIVLQSPV
PQSTQQHLSV VNSHGKFISQ PLQPKSPNPM TPPPPPPYPS QVIRPGMWPQ QQQQSHSRLI
SSNQGAIMLS ATGQCLVPQG SNSAQLLMSS PQSNVPMDTQ HLIPVCCQQS TQIEYIQRPC
VSHPMHGSNG PQRTPSTQQM IVHGQGGLHN QPVHVYQTDH ITSPNSRQFT GHPNSLSPGV
LRFNSGSEEV ILRCSTELQN PNNVISPNPM RSPNMEGNTH HVVLNRPSQQ NILPCTASNN
TQLCMTNSNS NVSNSASRRI NYHKWEEDER LGGQSTIAPV LHANISHPTL RGQYPEFTVR
AKEISKLWRR LSSEERGTWV IQARNNRTTL RSNQTNIPTT MGSVGIANTM PPTQPYCQPS
TLANQTIPLQ SGSDLSYPIE SPTAYTRPQN RTPHHIQSEQ QMNTNSPQQT KEPHRSLTPE
IPNNSYVQDR ILSSHMTSSS SNSSVDSVNA HHQAINKGLT FPNAELNTSG NILPQQHQQM
IGITTPSPGS SYMVSPVNSR PPSRHQTSLP PPPPIWPPSG NMNSLSTGSV SVNSPANLKQ
PTPPPSVCSS MSPAPIRSPA SIHVPTPTSF HIPHPYPPHG TSSLTSPAQS PVPPQSPSNI
NQLMRSSNAG TATPMPSSHP SPVPQSHHTI LPSGHHLTSQ SLLPSESSVN RQQNHSFAAS
HPATPGTPNS QLCGPGNTFS APATPGAGTS PGNVGVLSYS APTNPGNVFI VGSSAMHVSR
MTSEGDISQS VYSINTLPQS SSNEHVSSSL PVAVEQGPSV GNYTGSQQQT HTQQGNYSST
ELERQRLKEI LAKQVHQRQV QHQHHQQLLQ QQQLHLAQQE QEHIMSRHSL SQSTSGQQGS
SSSGLVYTSM NQSSSNLVHQ QPNESHCQPY ANYSNTPMWQ QHASVHDPYH SVSSQNQAHQ
QQSMRHAYFS QQVSAQHPAM FYQQSQTRPD PVSPSGSRIL TSVTSGIPSM SPHAPGQFIS
TANPPTQGDY TGAQNTSVPK ATRLTYPEMS ELVHQPQMVP DSLPNSYGIN NQAMISTSRS
NQQMVHSNTM QVYRNNVSQR SDHPSSMNPY HQMDVVTPSS LTSIDTQLIS DIPRAPSVAA
GLEEVGFEPP IIVSRLAAKD KRCAPVINVS LLSGSAYQTE HTVDQQRLSF DNTDGSAVTS
VTGGGDVANF PYRTTSEDKA IHLSNKYFM
//
