ID A0A3Q0KGV0_SCHMA Unreviewed; 546 AA.
AC A0A3Q0KGV0;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 18.
DE SubName: Full=Putative tgf-beta family {ECO:0000313|WBParaSite:Smp_063190.1};
OS Schistosoma mansoni (Blood fluke).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Trematoda;
OC Digenea; Strigeidida; Schistosomatoidea; Schistosomatidae; Schistosoma.
OX NCBI_TaxID=6183 {ECO:0000313|Proteomes:UP000008854, ECO:0000313|WBParaSite:Smp_063190.1};
RN [1] {ECO:0000313|Proteomes:UP000008854}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Puerto Rican {ECO:0000313|Proteomes:UP000008854};
RX PubMed=22253936; DOI=10.1371/journal.pntd.0001455;
RA Protasio A.V., Tsai I.J., Babbage A., Nichol S., Hunt M., Aslett M.A.,
RA De Silva N., Velarde G.S., Anderson T.J., Clark R.C., Davidson C.,
RA Dillon G.P., Holroyd N.E., LoVerde P.T., Lloyd C., McQuillan J.,
RA Oliveira G., Otto T.D., Parker-Manuel S.J., Quail M.A., Wilson R.A.,
RA Zerlotini A., Dunne D.W., Berriman M.;
RT "A systematically improved high quality genome and transcriptome of the
RT human blood fluke Schistosoma mansoni.";
RL PLoS Negl. Trop. Dis. 6:E1455-E1455(2012).
RN [2] {ECO:0000313|WBParaSite:Smp_063190.1}
RP IDENTIFICATION.
RC STRAIN=Puerto Rican {ECO:0000313|WBParaSite:Smp_063190.1};
RG WormBaseParasite;
RL Submitted (DEC-2018) to UniProtKB.
CC -!- SIMILARITY: Belongs to the TGF-beta family.
CC {ECO:0000256|ARBA:ARBA00006656, ECO:0000256|RuleBase:RU000354}.
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DR AlphaFoldDB; A0A3Q0KGV0; -.
DR STRING; 6183.A0A3Q0KGV0; -.
DR EnsemblMetazoa; Smp_063190.1; Smp_063190.1; Smp_063190.
DR WBParaSite; Smp_063190.1; Smp_063190.1; Smp_063190.
DR InParanoid; A0A3Q0KGV0; -.
DR Proteomes; UP000008854; Unassembled WGS sequence.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR CDD; cd08698; TGF_beta_SF; 1.
DR Gene3D; 2.10.90.10; Cystine-knot cytokines; 1.
DR InterPro; IPR029034; Cystine-knot_cytokine.
DR InterPro; IPR001839; TGF-b_C.
DR InterPro; IPR015615; TGF-beta-rel.
DR InterPro; IPR017948; TGFb_CS.
DR PANTHER; PTHR11848:SF292; INHIBIN BETA CHAIN; 1.
DR PANTHER; PTHR11848; TGF-BETA FAMILY; 1.
DR Pfam; PF00019; TGF_beta; 1.
DR PRINTS; PR00669; INHIBINA.
DR SMART; SM00204; TGFB; 1.
DR SUPFAM; SSF57501; Cystine-knot cytokines; 1.
DR PROSITE; PS00250; TGF_BETA_1; 1.
DR PROSITE; PS51362; TGF_BETA_2; 1.
PE 3: Inferred from homology;
KW Growth factor {ECO:0000256|ARBA:ARBA00023030,
KW ECO:0000256|RuleBase:RU000354}; Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000008854};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 24..42
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 417..546
FT /note="TGF-beta family profile"
FT /evidence="ECO:0000259|PROSITE:PS51362"
SQ SEQUENCE 546 AA; 64469 MW; E0D931139F71C26B CRC64;
MIIKNSALFL LPWLQYRINL KIKFLLNQLN IKFILLLIII IIKNQLKIDL FYSINASILK
GSSSPSLSSL SSNDYYYNYY HYRPTKKDLI QSYLDKPKNW LLQKTNNPFL SNLITNKDHI
NPYNNNNNNN ENDRTQQFNH NQYINKQTLS IIEKFKKKLL IQLNLKTVPN ININNESEWN
SLPIILRNRL KNEIDITNQL INKPIKQDEE KETLILLKQY QPPVKLPNPN IFILKVAEEI
DPTHISRVTL HVETNGEIRP NSIFTCWEIY PTLFKPKFLW LNNDNDDDAD DEDNDPTAET
FSQIDINNFD EIENDPNIQS TNLFNYPYKL TMNRMFKLIK PEIDKTILPE NYLTSMVTFN
ITNRMINWLK YNRNNQPYKP FIRYIMIICN NCDHEQQNII DPKKVVMEIK YRPRLKRQRR
SLTKGDETIY NVCRSNGHHY SCCTQPLSVK FSDIGWDNWI IHPKSFEPNY CRGSCKVTST
KSLHYDVMDL LLRKNLSQFG NVQRDEVQSC CHPTQLTSMS VLYLDSNREL QMHTLHNLIV
LGCACS
//
