ID A0A3Q0KHN2_SCHMA Unreviewed; 1501 AA.
AC A0A3Q0KHN2;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 24-JAN-2024, entry version 22.
DE SubName: Full=Retinoid-x-receptor (RXR) {ECO:0000313|WBParaSite:Smp_073470.1};
OS Schistosoma mansoni (Blood fluke).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Trematoda;
OC Digenea; Strigeidida; Schistosomatoidea; Schistosomatidae; Schistosoma.
OX NCBI_TaxID=6183 {ECO:0000313|Proteomes:UP000008854, ECO:0000313|WBParaSite:Smp_073470.1};
RN [1] {ECO:0000313|Proteomes:UP000008854}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Puerto Rican {ECO:0000313|Proteomes:UP000008854};
RX PubMed=22253936; DOI=10.1371/journal.pntd.0001455;
RA Protasio A.V., Tsai I.J., Babbage A., Nichol S., Hunt M., Aslett M.A.,
RA De Silva N., Velarde G.S., Anderson T.J., Clark R.C., Davidson C.,
RA Dillon G.P., Holroyd N.E., LoVerde P.T., Lloyd C., McQuillan J.,
RA Oliveira G., Otto T.D., Parker-Manuel S.J., Quail M.A., Wilson R.A.,
RA Zerlotini A., Dunne D.W., Berriman M.;
RT "A systematically improved high quality genome and transcriptome of the
RT human blood fluke Schistosoma mansoni.";
RL PLoS Negl. Trop. Dis. 6:E1455-E1455(2012).
RN [2] {ECO:0000313|WBParaSite:Smp_073470.1}
RP IDENTIFICATION.
RC STRAIN=Puerto Rican {ECO:0000313|WBParaSite:Smp_073470.1};
RG WormBaseParasite;
RL Submitted (DEC-2018) to UniProtKB.
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DR AlphaFoldDB; A0A3Q0KHN2; -.
DR STRING; 6183.A0A3Q0KHN2; -.
DR EnsemblMetazoa; Smp_073470.1; Smp_073470.1; Smp_073470.
DR WBParaSite; Smp_073470.1; Smp_073470.1; Smp_073470.
DR InParanoid; A0A3Q0KHN2; -.
DR Proteomes; UP000008854; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR CDD; cd06956; NR_DBD_RXR; 1.
DR Gene3D; 3.30.50.10; Erythroid Transcription Factor GATA-1, subunit A; 1.
DR Gene3D; 1.10.565.10; Retinoid X Receptor; 1.
DR InterPro; IPR035500; NHR-like_dom_sf.
DR InterPro; IPR000536; Nucl_hrmn_rcpt_lig-bd.
DR InterPro; IPR001723; Nuclear_hrmn_rcpt.
DR InterPro; IPR001628; Znf_hrmn_rcpt.
DR InterPro; IPR013088; Znf_NHR/GATA.
DR PANTHER; PTHR24083; NUCLEAR HORMONE RECEPTOR; 1.
DR PANTHER; PTHR24083:SF103; PROTEIN ULTRASPIRACLE; 1.
DR Pfam; PF00104; Hormone_recep; 1.
DR Pfam; PF00105; zf-C4; 1.
DR PRINTS; PR00398; STRDHORMONER.
DR PRINTS; PR00047; STROIDFINGER.
DR SMART; SM00430; HOLI; 1.
DR SMART; SM00399; ZnF_C4; 1.
DR SUPFAM; SSF57716; Glucocorticoid receptor-like (DNA-binding domain); 1.
DR SUPFAM; SSF48508; Nuclear receptor ligand-binding domain; 1.
DR PROSITE; PS51843; NR_LBD; 1.
DR PROSITE; PS00031; NUCLEAR_REC_DBD_1; 1.
DR PROSITE; PS51030; NUCLEAR_REC_DBD_2; 1.
PE 4: Predicted;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000008854};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT DOMAIN 912..987
FT /note="Nuclear receptor"
FT /evidence="ECO:0000259|PROSITE:PS51030"
FT DOMAIN 1130..1467
FT /note="NR LBD"
FT /evidence="ECO:0000259|PROSITE:PS51843"
FT REGION 378..404
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 677..707
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 987..1007
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1240..1271
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1482..1501
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 378..398
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 989..1007
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1501 AA; 165868 MW; EECB913AF6F4FDD0 CRC64;
MIPVSIVTPQ SVSSAEQIGE HSSSLSLQNV PVQQDSVSYL NSHTTVHMND GQNEPSSIYL
TDQELRLDSS FPNSPLGITR DPHCDDNGEE QNRISSFELI SRLIDAEGLI ELGYIPSSCN
SAPAIDVASL SDLEEVTSKT LLWSSNCDDV DSFNFDDLSN KINESNTNNA DTKLRSDNKT
LEHRSALTTE YISVDFNPLN STNALVPIIS LPSDTNLQTI PSLESNEYEN FQAHYKTNTV
LENVQSLPSN TVPDDLGPLN ITSYPMGLVE ADIPSITRPS IHQSPVDHHA LHPTIKPNHI
PYSYSPLTPL SSVQIRSSIH ESSFVIDNQV CPIDNICNQQ LQTGSFVKNK YSSDYQEYSG
APECFPTVHT LELFTSHSSD LPHSSSHPSK NVGESPKHLS NDTKPIKYPE LLQKIGENCN
SNISGPNLPF ISHSTYCSRT QSSSSCSIRQ QLATAPSHPQ LHVSIPQSPQ SIYSVFSCSP
NQKVAVSSTV NLPSSDSTSA TLIFNGDFPS RPIISSTDNS FWSHPSIPSG SAVNTQMITN
WEHSVPYPAY VPNSQITGFL PENISVTDKA AIYVKDGNST AIQPVLGSGL VGSFQYLTPT
TVLSKPNYTI LNDQLTFNHP QETLIQPFLP QMSDPIKTTQ NLRIPFCQGT QYTLTPGISI
PINPEHSFGR LEMNTHRYSS ESSKTNPALT SRSSSSRPFN SPVRRNSAPF QSTYQNCMNF
SETAAHQSEC SIVVSQLSTK KLTTPVLCCI SSNSNNIPII SQQSPNNNNN NNNNNNVVFK
TDNTKQHIID QNILTKTATT TSIVQPSELC HIQPILISSP VKNNNNNTHN LGTGSYIDSN
CLSNQSNNDK SHSITPSSPL LTNCNSPSTT LQSSTVCCLL RPSGRSTSTS SGSSCGSSCS
GTGGGVSVSS GQYICSICSD RASGKHYGVF SCEGCKGFFK RTVRKELTYI CRDSQECQID
KRLRNRCQYC RYQKCLRAGM RREAVQEERQ QQQLQSEVQR SPTPPEQNCD LSVNSMIMSD
TKITNAMNHS CLAEKQEIML KTTNCTSSSS PHLLSNCSDS SINYFYSASN EKSQQPSIND
NFNLTVNDAA TYPPQELSLI GNKDSNNVTL PLADIHALKL PTTTSAAIPP PPDALEFIRT
AESTISSRRK QWLSAFNKQQ CHAEIAKCFQ DSMENLKWLE NNFEKCTTNH LPLFDLVIWS
SKLPYICQLS CGVHLDLLKS ACMQLIIVNL VYWLANDHKP RSLSTSNSTS KLPDTTPTIN
STDISNITDD PPENSISDIS KDCTIQMKKI NKSVPLDEKM DYYYSNFPEF HLLNNLTKPM
DNNNNDSISS KPTNINDNSV DDDMIRKRNT NVYKLIYNLA IKLRMLNLDP VELGCLKLIL
LLNPDSMTCL NNIRSLIELL RDQVYAGLEY YCNQVWPNAP HGRMGRLLLK LSNFQSVAAR
IEKLICSNEL NNLLNNLESI FSYLSKKKVD HSNYISTTTT TTTTMSSTTT STSNSIHLEF
S
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