ID A0A3Q0KKB1_SCHMA Unreviewed; 1038 AA.
AC A0A3Q0KKB1;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=Helicase, putative {ECO:0000313|WBParaSite:Smp_120360.1};
OS Schistosoma mansoni (Blood fluke).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Trematoda;
OC Digenea; Strigeidida; Schistosomatoidea; Schistosomatidae; Schistosoma.
OX NCBI_TaxID=6183 {ECO:0000313|Proteomes:UP000008854, ECO:0000313|WBParaSite:Smp_120360.1};
RN [1] {ECO:0000313|Proteomes:UP000008854}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Puerto Rican {ECO:0000313|Proteomes:UP000008854};
RX PubMed=22253936; DOI=10.1371/journal.pntd.0001455;
RA Protasio A.V., Tsai I.J., Babbage A., Nichol S., Hunt M., Aslett M.A.,
RA De Silva N., Velarde G.S., Anderson T.J., Clark R.C., Davidson C.,
RA Dillon G.P., Holroyd N.E., LoVerde P.T., Lloyd C., McQuillan J.,
RA Oliveira G., Otto T.D., Parker-Manuel S.J., Quail M.A., Wilson R.A.,
RA Zerlotini A., Dunne D.W., Berriman M.;
RT "A systematically improved high quality genome and transcriptome of the
RT human blood fluke Schistosoma mansoni.";
RL PLoS Negl. Trop. Dis. 6:E1455-E1455(2012).
RN [2] {ECO:0000313|WBParaSite:Smp_120360.1}
RP IDENTIFICATION.
RC STRAIN=Puerto Rican {ECO:0000313|WBParaSite:Smp_120360.1};
RG WormBaseParasite;
RL Submitted (DEC-2018) to UniProtKB.
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DR AlphaFoldDB; A0A3Q0KKB1; -.
DR STRING; 6183.A0A3Q0KKB1; -.
DR EnsemblMetazoa; Smp_120360.1; Smp_120360.1; Smp_120360.
DR WBParaSite; Smp_120360.1; Smp_120360.1; Smp_120360.
DR InParanoid; A0A3Q0KKB1; -.
DR Proteomes; UP000008854; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0003724; F:RNA helicase activity; IEA:InterPro.
DR GO; GO:0006401; P:RNA catabolic process; IEA:InterPro.
DR CDD; cd18024; DEXHc_Mtr4-like; 1.
DR CDD; cd18795; SF2_C_Ski2; 1.
DR Gene3D; 1.10.3380.30; -; 2.
DR Gene3D; 2.40.30.300; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR048392; MTR4-like_stalk.
DR InterPro; IPR025696; MTR4_beta-barrel.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR016438; SKI2-like.
DR InterPro; IPR012961; Ski2/MTR4_C.
DR PANTHER; PTHR12131; ATP-DEPENDENT RNA AND DNA HELICASE; 1.
DR PANTHER; PTHR12131:SF7; EXOSOME RNA HELICASE MTR4; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF08148; DSHCT; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF21408; MTR4-like_stalk; 1.
DR Pfam; PF13234; MTR4_beta-barrel; 1.
DR PIRSF; PIRSF005198; Antiviral_helicase_SKI2; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM01142; DSHCT; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000008854}.
FT DOMAIN 130..286
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 354..555
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT REGION 1..68
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 686..711
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 814..841
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 17..32
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 33..68
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1038 AA; 117376 MW; D11334AA1C677F50 CRC64;
MSAFGLDLDE LTSAFDPKKP SSETSADTGS TQPGDFEEKK RKAEASLKPL LKEVGEDSTD
DSPKRSKLSV TDTLEFNAPR IQIHKISSPE TCTHEVAVPP DIEYKPITKD CGFPAKTFPF
TLDAFQQQAI ICIDNNQSVL LSAHTSAGKT VVAEYAIATA LREKQRVIYT TPIKALSNQK
YREFFEAFPE VGLLTGDATI NPSASVLIMT TEILQSMLYK GASMVREVGW VIFDEIHYMR
DPERGVVWEE TIVLLPDSVR YVFLSATIPN ARQFAEWIAH LHHQPCHVVS SDCRPVPLRH
YLYPVGSEGL FLVLDEGKYL EQNFERAMRS FLSDESSNKR QKSQVDYNKR SENNVIQIVR
LVKHRSLEPI IVFSFSKKEC EIYALQLAKF DFTTDAEKKV VDEVFRNAID GLSPEDRALP
QVESVLPLLK RGIGIHHGGL LPLLKETIEI LFSENLIKCL FATETFAMGL NMPARTVLFT
SARKYDGQSY RWITSGEYIQ MSGRAGRRGK DDSGTVILMV DESMTSELAH QIMMGPPPPL
NSAFHITYNM LLNLLRVEEI NPEYMMERSF CQFQNFSSLP NMYKELNELR ATYASTVVDD
EESVESYHQI QLCFDELVGQ QWQYIRRPQY IVPFLQPGRL VKIVVQSISY GWGAVINLKK
RQRKDRSSTP ESFYILDCLL CNNPSRSDSD ESGSDVPSGN PVDNLGITNS VTPTGSDTLP
MAEIIPVRLD CVVGISAVRL VVPNDLRSKE ARQGVLNAIE KVKVRMGGSL PVLDPIADMH
ISDPRFLEIN EKVTAFQERL QHHWLHDDPR LSELSKVYRK KEQLRKRIDA LTANLNSKVS
LIQLEELSAR KRVLRRLNFV SEYDVIELKG CVACEITSAD ELLLTELLFD GVFNRLSSEH
IAALLSCFVF EERASEMPKL TKELSDALRT LQDTARRIAR ISNECRLPVD EDNYVDSFKP
HLMDLVDAWT RGASFASVCS MTDLFEGTII RTLRLLEELL RQMANAARTI GSNVLEKKFV
EAIEKIKRDI VFAASLYL
//
