ID A0A3Q0KL07_SCHMA Unreviewed; 1372 AA.
AC A0A3Q0KL07;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE SubName: Full=Alpha integrin receptor 1; Putative integrin alpha {ECO:0000313|WBParaSite:Smp_126140.1};
OS Schistosoma mansoni (Blood fluke).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Trematoda;
OC Digenea; Strigeidida; Schistosomatoidea; Schistosomatidae; Schistosoma.
OX NCBI_TaxID=6183 {ECO:0000313|Proteomes:UP000008854, ECO:0000313|WBParaSite:Smp_126140.1};
RN [1] {ECO:0000313|Proteomes:UP000008854}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Puerto Rican {ECO:0000313|Proteomes:UP000008854};
RX PubMed=22253936; DOI=10.1371/journal.pntd.0001455;
RA Protasio A.V., Tsai I.J., Babbage A., Nichol S., Hunt M., Aslett M.A.,
RA De Silva N., Velarde G.S., Anderson T.J., Clark R.C., Davidson C.,
RA Dillon G.P., Holroyd N.E., LoVerde P.T., Lloyd C., McQuillan J.,
RA Oliveira G., Otto T.D., Parker-Manuel S.J., Quail M.A., Wilson R.A.,
RA Zerlotini A., Dunne D.W., Berriman M.;
RT "A systematically improved high quality genome and transcriptome of the
RT human blood fluke Schistosoma mansoni.";
RL PLoS Negl. Trop. Dis. 6:E1455-E1455(2012).
RN [2] {ECO:0000313|WBParaSite:Smp_126140.1}
RP IDENTIFICATION.
RC STRAIN=Puerto Rican {ECO:0000313|WBParaSite:Smp_126140.1};
RG WormBaseParasite;
RL Submitted (DEC-2018) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479,
CC ECO:0000256|RuleBase:RU003762}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004479, ECO:0000256|RuleBase:RU003762}.
CC -!- SIMILARITY: Belongs to the integrin alpha chain family.
CC {ECO:0000256|ARBA:ARBA00008054, ECO:0000256|RuleBase:RU003762}.
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DR AlphaFoldDB; A0A3Q0KL07; -.
DR STRING; 6183.A0A3Q0KL07; -.
DR EnsemblMetazoa; Smp_126140.1; Smp_126140.1; Smp_126140.
DR WBParaSite; Smp_126140.1; Smp_126140.1; Smp_126140.
DR InParanoid; A0A3Q0KL07; -.
DR Proteomes; UP000008854; Unassembled WGS sequence.
DR ExpressionAtlas; A0A3Q0KL07; baseline.
DR GO; GO:0008305; C:integrin complex; IEA:InterPro.
DR GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR GO; GO:0007229; P:integrin-mediated signaling pathway; IEA:UniProtKB-KW.
DR Gene3D; 1.20.5.930; Bicelle-embedded integrin alpha(iib) transmembrane segment; 1.
DR Gene3D; 2.130.10.130; Integrin alpha, N-terminal; 1.
DR Gene3D; 2.60.40.1510; ntegrin, alpha v. Chain A, domain 3; 1.
DR Gene3D; 2.60.40.1530; ntegrin, alpha v. Chain A, domain 4; 1.
DR InterPro; IPR013517; FG-GAP.
DR InterPro; IPR013519; Int_alpha_beta-p.
DR InterPro; IPR000413; Integrin_alpha.
DR InterPro; IPR018184; Integrin_alpha_C_CS.
DR InterPro; IPR048285; Integrin_alpha_Ig-like_2.
DR InterPro; IPR048286; Integrin_alpha_Ig-like_3.
DR InterPro; IPR028994; Integrin_alpha_N.
DR InterPro; IPR032695; Integrin_dom_sf.
DR PANTHER; PTHR23220; INTEGRIN ALPHA; 1.
DR PANTHER; PTHR23220:SF122; INTEGRIN ALPHA-PS1; 1.
DR Pfam; PF01839; FG-GAP; 1.
DR Pfam; PF20805; Integrin_A_Ig_2; 1.
DR Pfam; PF20806; Integrin_A_Ig_3; 2.
DR PRINTS; PR01185; INTEGRINA.
DR SMART; SM00191; Int_alpha; 4.
DR SUPFAM; SSF69318; Integrin alpha N-terminal domain; 1.
DR SUPFAM; SSF69179; Integrin domains; 2.
DR PROSITE; PS51470; FG_GAP; 2.
DR PROSITE; PS00242; INTEGRIN_ALPHA; 1.
PE 3: Inferred from homology;
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889,
KW ECO:0000256|RuleBase:RU003762};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Integrin {ECO:0000256|ARBA:ARBA00023037, ECO:0000256|RuleBase:RU003762};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU003762};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU003762};
KW Reference proteome {ECO:0000313|Proteomes:UP000008854};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|RuleBase:RU003762};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU003762};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU003762}.
FT SIGNAL 1..27
FT /evidence="ECO:0000256|RuleBase:RU003762"
FT CHAIN 28..1372
FT /evidence="ECO:0000256|RuleBase:RU003762"
FT /id="PRO_5017850526"
FT TRANSMEM 1311..1333
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU003762"
FT REPEAT 344..404
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 447..511
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT DOMAIN 768..863
FT /note="Integrin alpha second immunoglobulin-like"
FT /evidence="ECO:0000259|Pfam:PF20805"
FT DOMAIN 1040..1084
FT /note="Integrin alpha third immunoglobulin-like"
FT /evidence="ECO:0000259|Pfam:PF20806"
FT DOMAIN 1108..1276
FT /note="Integrin alpha third immunoglobulin-like"
FT /evidence="ECO:0000259|Pfam:PF20806"
SQ SEQUENCE 1372 AA; 155108 MW; A17B34D12D636701 CRC64;
MHHLTIMLNS QLLYLLVFFT SYTLSSSYRE NKIVQDLLLY PPDSARLYTH INRGSYFGYS
VATYIGQSQP SCLVGAPKAS HGSSSISMNE STGVVYRLDM DLTFPFCSVV PIATTDELRK
EVGTPTPGVS HWLGGTVAAA NNAVDGIQLG CDFRYLLNSD LMNEIPNDLT VNSVNQYKSS
VKSKSSLGIG NCALYTGTSM QYVSVDPCNS QEEGACLAGF SADVQAGNQS GEALVALGMP
GSYLTEGNIF LGRYRGRELI NAIRLKSSSH DLKHKGFGLG YAIALAKLNN NDNKLGEQHK
HLQSDDRQHF QSNINVITSS PMWIDNDYRG IIMILNQAMD LGGITYLKDK WSHVGSYFGY
SLAVADLDGN GLVDIIVGAP YFTRRQNQEG LQDTINSKQF NHNEGSQWSN LLPDIGRVYI
FYGNHLNLSN LLSDSKQRPE IPDYFTQDPV ILQGPKSPKG RFGHALTNIG DIDGDGTEDL
AVSCPYCTDP DGRTHKGAVF IYLGKKDSIL DTEPFQTIWP SDLPKQSPVT ICGSTDFTND
YASDVPRLFK AFGWSLSGSY DLDGNHAPDL VVGDYESDQV VMLRGRNTLW FDLPNWELPT
QPTLSWRYKD TLTCDEQCYF PIQLSARING KQHLLKQIKD WKLRLSIDLD SDVEQPENKR
LTIQATRKQT IYQSTDKGII DMLVELKTDE LMEENSSRIT LFDFIVKPLI SKISTLLWKP
VRINVTLNPV HEPMSFVEHK SISSWILHPF LGNRTFISRS MQFANPACGV DNICRPDLQV
QMIDISEGPT DKSIIYFRER VSQRNITVHI GNLGENAYST QLHMIFPDQL SFSIPEGLLC
QTVTLSDMKQ TQLICNLDDP LSYTGNDHLY SFTFQINTAG AFRQLDEPVN DQPENISDHD
HSHNYNDDKK KIDYSLSRTI NKPKHEDDNE MKTDFYRHSS SVKRDNNNDY EESYVKPIYH
SYQLKRNKRD TLSIPKDLTI TAKVISGNTD DNINNNEASI TYQLKLAAKV ELSSSALDRT
IIDFRNFSVQ PYEMQRIHPE TIGPELKHIY LVTNAGPSPL ENVWVNLTIP IQTRDGEYLV
YLLDRLRYQA EDGGPPRFEN ISPDVVSAEG HVRGLCITPE WALNPLRLNA VHRNRVEESS
KSRSLSRSFR SQLSMTRYRR SVNRKIKNRE LSYLNDKHNF IDDNQPINSK DTIRNARSIL
HGVRKRQQEI IKCGEKVSDL GYPVCAVISC RVNGLSRGDA VRIVLRGWIW ADTFFRHKIS
DFAIVSEANA KLEETAFGIK IDSNLTIQPL AISQNFVFEG INVSLFREIP LWPFILGSVL
GLALLALLIF TMWRCGFFHR KQIYDNHFQQ YPHDNNNNGN SINPLFIEPR KN
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