ID A0A3Q0KLJ8_SCHMA Unreviewed; 1721 AA.
AC A0A3Q0KLJ8;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=LisH domain-containing protein {ECO:0000313|WBParaSite:Smp_130180.1};
OS Schistosoma mansoni (Blood fluke).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Trematoda;
OC Digenea; Strigeidida; Schistosomatoidea; Schistosomatidae; Schistosoma.
OX NCBI_TaxID=6183 {ECO:0000313|Proteomes:UP000008854, ECO:0000313|WBParaSite:Smp_130180.1};
RN [1] {ECO:0000313|Proteomes:UP000008854}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Puerto Rican {ECO:0000313|Proteomes:UP000008854};
RX PubMed=22253936; DOI=10.1371/journal.pntd.0001455;
RA Protasio A.V., Tsai I.J., Babbage A., Nichol S., Hunt M., Aslett M.A.,
RA De Silva N., Velarde G.S., Anderson T.J., Clark R.C., Davidson C.,
RA Dillon G.P., Holroyd N.E., LoVerde P.T., Lloyd C., McQuillan J.,
RA Oliveira G., Otto T.D., Parker-Manuel S.J., Quail M.A., Wilson R.A.,
RA Zerlotini A., Dunne D.W., Berriman M.;
RT "A systematically improved high quality genome and transcriptome of the
RT human blood fluke Schistosoma mansoni.";
RL PLoS Negl. Trop. Dis. 6:E1455-E1455(2012).
RN [2] {ECO:0000313|WBParaSite:Smp_130180.1}
RP IDENTIFICATION.
RC STRAIN=Puerto Rican {ECO:0000313|WBParaSite:Smp_130180.1};
RG WormBaseParasite;
RL Submitted (DEC-2018) to UniProtKB.
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC {ECO:0000256|ARBA:ARBA00004906}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the VPRBP/DCAF1 family.
CC {ECO:0000256|ARBA:ARBA00008845}.
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DR AlphaFoldDB; A0A3Q0KLJ8; -.
DR STRING; 6183.A0A3Q0KLJ8; -.
DR EnsemblMetazoa; Smp_130180.1; Smp_130180.1; Smp_130180.
DR WBParaSite; Smp_130180.1; Smp_130180.1; Smp_130180.
DR InParanoid; A0A3Q0KLJ8; -.
DR UniPathway; UPA00143; -.
DR Proteomes; UP000008854; Unassembled WGS sequence.
DR ExpressionAtlas; A0A3Q0KLJ8; baseline.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR006594; LisH.
DR InterPro; IPR033270; VPRBP/DCAF1.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR PANTHER; PTHR13129:SF4; DDB1- AND CUL4-ASSOCIATED FACTOR 1; 1.
DR PANTHER; PTHR13129; VPRBP PROTEIN-RELATED; 1.
DR Pfam; PF08513; LisH; 1.
DR SMART; SM00667; LisH; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS50896; LISH; 1.
PE 3: Inferred from homology;
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000008854};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786}.
FT REGION 561..591
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 606..688
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 748..820
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1075..1096
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1563..1605
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1617..1656
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1683..1721
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 614..628
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 629..669
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 770..788
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 801..820
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1575..1605
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1617..1634
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1701..1721
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1721 AA; 193221 MW; 855891BCDE6404DD CRC64;
MSEGRTAIQR CEELISRWKS ERNSPTFDPV PLLNNFSELL EEQINLFFST DPDPFDDRHP
LRTDSSCDLG QILRLLSSHD AFLERLTYVY LLGSNDPSNE LVIAASRLLC AMRLGVTLSF
SLDEEDVIIN TLYKLALSET EPTNCYALFL LGSVLDNTEL LYITRQKNIQ LIPIVLNRLL
TYTGQLKNEL SSNTQSTYEG GMTNLLGSFI LNPLKTEMKI RLSIAYLIPL AEYQDLMPFM
YNGGILDLIY TYLMPEVASR DIRLTFEALR LLANLLCHRC VYLEFVEQDG LQSVLKVPRP
SVAATAVSVV LYYTAYFEDA MERVCQLSSS LLDDLIKYSL WLVECSHPSA RCYSLFFLHL
VLCYGITFRR FEQQNGLVYL YNAICVLPLR LTEDNPTTLK DTTSWHVVRA SLCAIRRFLE
ISLLLWIDTI DPSLASLFDE SPRAVAAVGC RPITYTAEQF SRLMSLIISR IRPDTVWQPT
QQLRDCGAID VLYRIIARNV YAHNNWPCRS ECTRLAVDIF NLMSITYDLA DEIVSADVYS
FPTSLSSATF LGPTPLLSSL AAGGDSPSSE FGSTDVTVHL PSPRGNNPTH RRGLINQLLQ
IVEQVGNEGI GGGGRESSRE DRRRPGLRRS GNQSNGATSN PVLSTENPQR PNVTPTTVSN
FASESTSRSQ ERTSDGEENG AEGSSTLDER INGLHMLFSI SREDDNWDVS VHKAVLAFIC
TLVYRPVVEH EHPDQPISVT GLLSNFTSAP NSNMGNHAPS SPPPPRNSTN TTPSSNSFKT
PQRTNGARGS VNRKRRYDET VALSSPSSIS SNVCSRLNQP STPYQQTGTH LVQFSESYMP
SPFGRQKSTQ LLYRQAKLWN IVRRQHGIMV LLYHLETKQP ISEADSVRTL ACRGLVGLAR
SEEVRSMLAK LPLFTKALLQ LLMKEPVLPD RLTEHAEFCR YATMLIRLVV GTLSDGVLSG
DMSLERVRRA EIVAKTRIQW DQEELLELIY RHLQSKGLHE SATALQQEAR LKIVPAAPSQ
LPLYDDFSRP PGETPPYQPS SGVVHVSDYL NTSVDSYNSS SKRDFDTNES TSMVSNCENI
GPNSDNNTTN TCGELPPTPN LRLTKIRHNA TPSQTPKPCR DRFERPGLPN LYLKPISTQP
VSEMTLSKVV ESFLLHQHSQ CPHPVSVCPK FSLYYPHRCP EPRLNKQTNC CQRLLLREDL
CGSLRLKPST KELRHFLHRR FQPTAVIREA DDDMLTACCF SRTDDGLFLG SNSGAIAWVN
VEEDGLPIEL FHIQSSSIRR LAHTRDGERL LVCSEWNEPA TVVARLRPST NASSNSNSPW
ETVSDDFVFR VSEARHAEFS NTGHQDRLVA TYGKMAKVFD LTTRTRVADL FSAVKQSGYI
LNKATFSPSD YLVLNDGVVW DLRCTGLLST SFSSSLQYPG TSSRPIHKFD KFQDIVSGVF
HPNGLEIIIG SAVWDLRTWR LLHTIQPLDR LEVQFNASYD VIYAGIFGLD DEEYAELGSN
RLAMQNMFRT VDAIDYSLIA SVDVRHRIEQ LALDTAGQSL ALVEKIGENN SSEPITQCRI
YMIGRKRGER EPDNDDEEGR EDEEDDEDDD DDDDDDDDDD LLNGDASDEL AQILDESSDD
ISTSDSSDWS PSSNEQQRVR RRRRRRRRTE ANANITESNT VNEVANNNDI NPILNAENAL
IDSQAESNEV MDRANDGDDD SSWETLEEEE VTEGMETSSE D
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