ID A0A3Q0KNZ6_SCHMA Unreviewed; 2396 AA.
AC A0A3Q0KNZ6; A0A5K4EQH7;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2023, sequence version 2.
DT 24-JAN-2024, entry version 22.
DE SubName: Full=Putative tuberin {ECO:0000313|WBParaSite:Smp_146060.1, ECO:0000313|WBParaSite:Smp_146060.2};
OS Schistosoma mansoni (Blood fluke).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Trematoda;
OC Digenea; Strigeidida; Schistosomatoidea; Schistosomatidae; Schistosoma.
OX NCBI_TaxID=6183 {ECO:0000313|Proteomes:UP000008854, ECO:0000313|WBParaSite:Smp_146060.1};
RN [1] {ECO:0000313|Proteomes:UP000008854}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Puerto Rican {ECO:0000313|Proteomes:UP000008854};
RX PubMed=22253936; DOI=10.1371/journal.pntd.0001455;
RA Protasio A.V., Tsai I.J., Babbage A., Nichol S., Hunt M., Aslett M.A.,
RA De Silva N., Velarde G.S., Anderson T.J., Clark R.C., Davidson C.,
RA Dillon G.P., Holroyd N.E., LoVerde P.T., Lloyd C., McQuillan J.,
RA Oliveira G., Otto T.D., Parker-Manuel S.J., Quail M.A., Wilson R.A.,
RA Zerlotini A., Dunne D.W., Berriman M.;
RT "A systematically improved high quality genome and transcriptome of the
RT human blood fluke Schistosoma mansoni.";
RL PLoS Negl. Trop. Dis. 6:E1455-E1455(2012).
RN [2] {ECO:0000313|WBParaSite:Smp_146060.1}
RP IDENTIFICATION.
RC STRAIN=Puerto Rican {ECO:0000313|WBParaSite:Smp_146060.1,
RC ECO:0000313|WBParaSite:Smp_146060.2};
RG WormBaseParasite;
RL Submitted (DEC-2018) to UniProtKB.
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DR AlphaFoldDB; A0A3Q0KNZ6; -.
DR STRING; 6183.A0A3Q0KNZ6; -.
DR EnsemblMetazoa; Smp_146060.1; Smp_146060.1; Smp_146060.
DR EnsemblMetazoa; Smp_146060.2; Smp_146060.2; Smp_146060.
DR WBParaSite; Smp_146060.1; Smp_146060.1; Smp_146060.
DR WBParaSite; Smp_146060.2; Smp_146060.2; Smp_146060.
DR InParanoid; A0A3Q0KNZ6; -.
DR Proteomes; UP000008854; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:InterPro.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR GO; GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.
DR Gene3D; 3.40.50.11210; Rap/Ran-GAP; 1.
DR InterPro; IPR035974; Rap/Ran-GAP_sf.
DR InterPro; IPR000331; Rap/Ran_GAP_dom.
DR InterPro; IPR046859; RGPA/RALGAPB_N.
DR InterPro; IPR027107; Tuberin/Ral-act_asu.
DR PANTHER; PTHR10063:SF11; RHO GTPASE-ACTIVATING PROTEIN CG5521-RELATED; 1.
DR PANTHER; PTHR10063; TUBERIN; 1.
DR Pfam; PF20412; RALGAPB_N; 1.
DR Pfam; PF02145; Rap_GAP; 1.
DR SUPFAM; SSF111347; Rap/Ran-GAP; 1.
DR PROSITE; PS50085; RAPGAP; 1.
PE 4: Predicted;
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW Reference proteome {ECO:0000313|Proteomes:UP000008854}.
FT DOMAIN 1998..2204
FT /note="Rap-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50085"
FT REGION 170..197
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1788..1822
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2264..2325
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1788..1807
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2396 AA; 270856 MW; 6C6C9DA9157ABC03 CRC64;
MFRRHRPSDT SAVKSRKKFL SEKESTHKIK HLKILIDSLS DDELQPFFVE NSSLIFQVFS
DCFFSFEWDV KLKGSSNCIK ELEVVLTVFE KVLLLLPEHI HQRWQHNCII EVIEDLLYEK
NALTIRKRGI RLFLIWYQIL GLNATSVCHR IFYNLVPEFG PLIAEYQKRE NDQRKRSHPH
ARNLSTDTRG QMMQESKSSN VVAPRERVAL LTATALGEDE SFDDKSLVLL QSLLHFLVSE
SFKIEWSQLR YEQHLMQLWF LFEKLKHSYL PVIFPCLSPL YSIYSPSTSS QVNNTVPLTS
NILQDYPIHP SRLSYYQLEF ACWLATFVYT GPRESSHAIS SDGGFDSNFT IHGSVVGTTG
PSFNLAGSFP WDTHGDPNDF LLSRHFRSFI GCPGHGEFES GSYSKANSYA KLSSSPPVQV
PIYLRNGDEN FVQEPTNLAA SNLSPKLNSY SVKDTAVIPS TVQTSPLPQK FIFTEPFFNY
DEKVVSMVHE VLYGCRQNIN LVQDILHQAL LLPLECHKAL FFIVTVYGSW LENKHNRPIF
MQASDSPVKS ITPSAKSQVN ASSIEHSQML KMNGRMNDLK QIQQSQIEDF PIDETKSKDD
VGINDPEELK GCLQNTIQIM LENMANIFYA SSLNPNLSES QNTNRISTSG TDYTKYQIDL
CRLVLQIFQF ASNSNELTSE TWSKLLSILM DIMRKTMVNT SPSNVQNYKW LSNNKLTQNL
FQTLNGALLR ASLFSTISSE PWDQCLNIYS QLSHWPSLII EWKKVMRMLT CTMSKLVYGV
DLSDLPQEKK GPRIKRLAGS TNPATRTRPK SLTEAALNYH NDNITTTAST TTTTYIGTDL
ANVLSSPPVP YPSALSVLSI HQNSLDDDNL ASTTDSIELH LSSQENSQKR FAASNELKTL
RNDNNTRQCI EKWTFDTISS KNYVLDNNND NGNVVHSYIP PRVSSINGTH DESNLQMSSN
DLTEVYGNHA LHNSRSISHD LSNQNESKQF NVTVKSETSI SESRRMSSVR RATSEITLEV
VKFDLDSPQS PVRTYFDENI DVGTSNIPRL CDILSDEHST LEPNSKDILT AAPSQEVSIT
NETSKLPSNT SNDQLNTADL PRCILAGGSA LGWTHESIVI CWRRFLGILG SLHKITNPTT
MSDIFNYLNE MTSCLLKIRA YQSVPSVTET CVQPIPQFVP PVNFIAPILF NTMSLSEEFM
EAKKIAIRTL CDIVVRSHDG CPDPELIAYF YYLIHQISVT KQENYVFEVI RSCNMRLFGS
SLPSTHLLIL DFLSDVNVVL SNPNSGTEIP RSEATSIILS LLCYPYHFNH LESIDPMSMK
AKTILCIDLK SNLVHSLIQA VLSDPSGEVR CLAITGLSIY CVIELVNSFS RESKTGPSVN
FKPMDDLFLE SIIILLGMMR FKNRAISIVA VEMINTLAEY CHLLLYRDAK LPSLVLLSLA
WTLYSTWDNM DLDSMSSTDK QFFHSLIQSI IEWSMRIPYD QLMKNFENKA ELKLLPASNL
LDIIIEVLCF IISNNTNSQT SVQNSNYPQS KILSSMNFTD PLREYINRCK QLIDINLFNA
PKSDLDLSTM TAKSWIVTNA ENTMIPYHYN DDMNRTMESV RLAAQMAMSH LLNHLDQFPM
SKQCVQLNTS IQERHDQLAH SISSAQKQFT TNNHSNMDDL SELTAEIFEQ NNLQIFVLDR
SIILTFLSLP IVKLPVQLKN INDNVSPTTV SSDKDNTELQ VVEFNNSTYS YLPLSYLNSK
DVEVDSSKSS LITDKFYTRI ITRDLSGKYS WDVSYLYASL VDMKEKQENQ QLNEPTNTNL
RLVDSDDSNS HLITRDPPPC PPPRVNPPPL ITNSLAPNTI DQLDRLSGVL RDLAITSPEC
SINWCTSKLC EYENLKNISD KEKAACLNME KMTCDQITAQ YQIDENVTHR KLPDIDVLSL
YNSHISQPKT GSRNSLKYTI CSLINDRKIS VQELESMKQN TLQFYNSRHL LNQLGYLSWK
HRPTVELLQI SPALIRELKH LDNLGSRETH KLAIFYVGAG QEDKQSILSN QTASLEFENF
VAGLGWEVDL LKHKGFRGGL ECSGRAGLST PYYATSTLEV IFHVSTRMPS STQEDLKYKH
LGNDEIMIIW NENSRAFRRS ILRTQFGDVL IIISPLLNGL FKVEVRREAQ VGLFGPIVEN
AILTANVLPG LVRATAINAS RAVQAIKPGY RHPYEDRASS LRQIISKYTL STCFEEYAAS
ILLPNSKSVH HNQSNLSLNR GVVSKSGGVK FSDVPPITQE TYHSYSQNST SDLAPNDVTN
NNNNTLKHTD DVTQTPSVRQ RQQTVSVSSH RATSAHSRTS SVTRAKSMFS RHHVDNLNTK
PISVTSQPSL KTNSTTLHHH NETPDMYKAN VFNSVPSPRL FRGLRSRQHS GSNKIN
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