ID A0A3Q0KP82_SCHMA Unreviewed; 841 AA.
AC A0A3Q0KP82;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 24-JAN-2024, entry version 19.
DE SubName: Full=Putative netrin {ECO:0000313|WBParaSite:Smp_146840.1};
OS Schistosoma mansoni (Blood fluke).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Trematoda;
OC Digenea; Strigeidida; Schistosomatoidea; Schistosomatidae; Schistosoma.
OX NCBI_TaxID=6183 {ECO:0000313|Proteomes:UP000008854, ECO:0000313|WBParaSite:Smp_146840.1};
RN [1] {ECO:0000313|Proteomes:UP000008854}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Puerto Rican {ECO:0000313|Proteomes:UP000008854};
RX PubMed=22253936; DOI=10.1371/journal.pntd.0001455;
RA Protasio A.V., Tsai I.J., Babbage A., Nichol S., Hunt M., Aslett M.A.,
RA De Silva N., Velarde G.S., Anderson T.J., Clark R.C., Davidson C.,
RA Dillon G.P., Holroyd N.E., LoVerde P.T., Lloyd C., McQuillan J.,
RA Oliveira G., Otto T.D., Parker-Manuel S.J., Quail M.A., Wilson R.A.,
RA Zerlotini A., Dunne D.W., Berriman M.;
RT "A systematically improved high quality genome and transcriptome of the
RT human blood fluke Schistosoma mansoni.";
RL PLoS Negl. Trop. Dis. 6:E1455-E1455(2012).
RN [2] {ECO:0000313|WBParaSite:Smp_146840.1}
RP IDENTIFICATION.
RC STRAIN=Puerto Rican {ECO:0000313|WBParaSite:Smp_146840.1};
RG WormBaseParasite;
RL Submitted (DEC-2018) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00460}.
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DR AlphaFoldDB; A0A3Q0KP82; -.
DR STRING; 6183.A0A3Q0KP82; -.
DR EnsemblMetazoa; Smp_146840.1; Smp_146840.1; Smp_146840.
DR WBParaSite; Smp_146840.1; Smp_146840.1; Smp_146840.
DR InParanoid; A0A3Q0KP82; -.
DR Proteomes; UP000008854; Unassembled WGS sequence.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR CDD; cd00055; EGF_Lam; 3.
DR Gene3D; 2.60.120.260; Galactose-binding domain-like; 2.
DR Gene3D; 2.10.25.10; Laminin; 2.
DR InterPro; IPR008211; Laminin_N.
DR InterPro; IPR002049; LE_dom.
DR InterPro; IPR001134; Netrin_domain.
DR InterPro; IPR018933; Netrin_module_non-TIMP.
DR InterPro; IPR008993; TIMP-like_OB-fold.
DR PANTHER; PTHR10574:SF365; NETRIN-A-RELATED; 1.
DR PANTHER; PTHR10574; NETRIN/LAMININ-RELATED; 1.
DR Pfam; PF00053; Laminin_EGF; 3.
DR Pfam; PF00055; Laminin_N; 1.
DR Pfam; PF01759; NTR; 1.
DR SMART; SM00180; EGF_Lam; 3.
DR SMART; SM00136; LamNT; 1.
DR SUPFAM; SSF57196; EGF/Laminin; 3.
DR SUPFAM; SSF50242; TIMP-like; 2.
DR PROSITE; PS01248; EGF_LAM_1; 1.
DR PROSITE; PS50027; EGF_LAM_2; 1.
DR PROSITE; PS51117; LAMININ_NTER; 1.
DR PROSITE; PS50189; NTR; 1.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00460};
KW Laminin EGF-like domain {ECO:0000256|ARBA:ARBA00023292,
KW ECO:0000256|PROSITE-ProRule:PRU00460};
KW Reference proteome {ECO:0000313|Proteomes:UP000008854};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}.
FT DOMAIN 79..430
FT /note="Laminin N-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51117"
FT DOMAIN 550..600
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 618..778
FT /note="NTR"
FT /evidence="ECO:0000259|PROSITE:PS50189"
FT DISULFID 572..581
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 584..598
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
SQ SEQUENCE 841 AA; 97627 MW; 9C79616821F6F9A5 CRC64;
MELLFYLMVI IQFINVIHNN LHGEQYKFNY PLQSNRKILK KQNNLYAKRN HVDHNSERLK
RNFLVDINSH NSLCQSGSQS FQCAPPFKDI SRGVSVYSTS TCGEHQPQNL CRSNTNCQLC
SVNSTKWKFS SEYLTDRHDV ENQTCWASGY IRPGEAVNLT ISLGKRFEVY YISLQPCSIG
SIPHSIAIYK SSDFGRTWRP WHYFSTDCYR AFGLPTSNEH NSHITSANLQ EVLCVALQPR
ESYYSHQGRR VRSMNSYIFN KPNITRNFGG MGVPSDWVIA FSTTLGRPAT RPWSPALIDW
MTMTDVRISL MSFHQSNEPE YRIKRNAYRS QLSDHSKLTQ NSQTINKLPL FQSNYFYDNF
NKYQLKRTRN LRDGQTITEL PQKEMNHTNN IDSQTDLKVN IRKSVNVTID PKILSEIDFY
AFADIAIGGR CKCNGHASEC ILGSNGKLIC ACEHHTSGED CEYCKPGYMD RPWDRATTQD
ANVCKKCDCN LHSNECRFSN SLYLLSNRIS GGICENCQHN TIGRNCHQCA EGYYRDWTKP
ISHENVCLPC RCHPIGSIVR HDCDRRSGQC RCKQGVAGLT CDRCQDGYHQ TRSPLNPCTK
DFTSRAVALA HTPGDINCPP CSTNKERIKL KKFCRKDAVF EASFKSRELH ENMARFEMHI
TQIWRINKEF FKGSSSTYWP ASKSFIDFEQ HNQGEHEEEI RRKSNELVPV WVRLNELKCK
CPYIELGVSY LIVTDFESFT NKIRNELLFS TKTAILPWRS SWKRRLIRFR RRENRGACEK
FREPTKLLSV FRPKQTLEIP TIHHEWHSTI NARIPSSIHQ RPSYSLSLRP YSKYRRDYKV
S
//
