ID A0A3Q0KQ45_SCHMA Unreviewed; 1373 AA.
AC A0A3Q0KQ45;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2023, sequence version 2.
DT 27-MAR-2024, entry version 19.
DE RecName: Full=protein-tyrosine-phosphatase {ECO:0000256|ARBA:ARBA00013064};
DE EC=3.1.3.48 {ECO:0000256|ARBA:ARBA00013064};
OS Schistosoma mansoni (Blood fluke).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Trematoda;
OC Digenea; Strigeidida; Schistosomatoidea; Schistosomatidae; Schistosoma.
OX NCBI_TaxID=6183 {ECO:0000313|Proteomes:UP000008854, ECO:0000313|WBParaSite:Smp_152750.1};
RN [1] {ECO:0000313|Proteomes:UP000008854}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Puerto Rican {ECO:0000313|Proteomes:UP000008854};
RX PubMed=22253936; DOI=10.1371/journal.pntd.0001455;
RA Protasio A.V., Tsai I.J., Babbage A., Nichol S., Hunt M., Aslett M.A.,
RA De Silva N., Velarde G.S., Anderson T.J., Clark R.C., Davidson C.,
RA Dillon G.P., Holroyd N.E., LoVerde P.T., Lloyd C., McQuillan J.,
RA Oliveira G., Otto T.D., Parker-Manuel S.J., Quail M.A., Wilson R.A.,
RA Zerlotini A., Dunne D.W., Berriman M.;
RT "A systematically improved high quality genome and transcriptome of the
RT human blood fluke Schistosoma mansoni.";
RL PLoS Negl. Trop. Dis. 6:E1455-E1455(2012).
RN [2] {ECO:0000313|WBParaSite:Smp_152750.1}
RP IDENTIFICATION.
RC STRAIN=Puerto Rican {ECO:0000313|WBParaSite:Smp_152750.1};
RG WormBaseParasite;
RL Submitted (DEC-2018) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] +
CC phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136, Rhea:RHEA-
CC COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:46858,
CC ChEBI:CHEBI:82620; EC=3.1.3.48;
CC Evidence={ECO:0000256|ARBA:ARBA00001490};
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DR STRING; 6183.A0A3Q0KQ45; -.
DR EnsemblMetazoa; Smp_152750.1; Smp_152750.1; Smp_152750.
DR EnsemblMetazoa; Smp_152750.2; Smp_152750.2; Smp_152750.
DR WBParaSite; Smp_152750.1; Smp_152750.1; Smp_152750.
DR Proteomes; UP000008854; Unassembled WGS sequence.
DR ExpressionAtlas; A0A3Q0KQ45; baseline.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004725; F:protein tyrosine phosphatase activity; IEA:InterPro.
DR GO; GO:0016311; P:dephosphorylation; IEA:InterPro.
DR CDD; cd00063; FN3; 2.
DR Gene3D; 2.60.40.10; Immunoglobulins; 3.
DR Gene3D; 3.90.190.10; Protein tyrosine phosphatase superfamily; 2.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR InterPro; IPR000242; PTP_cat.
DR InterPro; IPR016130; Tyr_Pase_AS.
DR InterPro; IPR003595; Tyr_Pase_cat.
DR InterPro; IPR000387; Tyr_Pase_dom.
DR PANTHER; PTHR19134; RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE; 1.
DR PANTHER; PTHR19134:SF449; RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE GAMMA; 1.
DR Pfam; PF00041; fn3; 2.
DR Pfam; PF00102; Y_phosphatase; 2.
DR PRINTS; PR00700; PRTYPHPHTASE.
DR SMART; SM00060; FN3; 3.
DR SMART; SM00409; IG; 1.
DR SMART; SM00194; PTPc; 2.
DR SMART; SM00404; PTPc_motif; 2.
DR SUPFAM; SSF52799; (Phosphotyrosine protein) phosphatases II; 2.
DR SUPFAM; SSF49265; Fibronectin type III; 2.
DR PROSITE; PS50853; FN3; 2.
DR PROSITE; PS50835; IG_LIKE; 1.
DR PROSITE; PS00383; TYR_PHOSPHATASE_1; 1.
DR PROSITE; PS50056; TYR_PHOSPHATASE_2; 1.
DR PROSITE; PS50055; TYR_PHOSPHATASE_PTP; 2.
PE 4: Predicted;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Protein phosphatase {ECO:0000256|ARBA:ARBA00022912};
KW Reference proteome {ECO:0000313|Proteomes:UP000008854};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 573..595
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 29..94
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 116..207
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 328..431
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 658..916
FT /note="Tyrosine-protein phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS50055"
FT DOMAIN 833..907
FT /note="Tyrosine specific protein phosphatases"
FT /evidence="ECO:0000259|PROSITE:PS50056"
FT DOMAIN 973..1195
FT /note="Tyrosine-protein phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS50055"
SQ SEQUENCE 1373 AA; 156634 MW; 212D0791EF67AE52 CRC64;
MFEAANALVL FSAVIIHPNI WCIKLSTLPV PLLRTNVTRH FRVGSDITLK CGENHHLNPT
LVLWLDPLNK TTSKETISLR NASIAQSGEY YCRLFLNGDL KYHQSLLVVI QDKPFSPTSI
VIQALSESSM NVSWVFGNSQ NSPISLHTVY LHDNNSLVLQ KNVSSPLSST TLHNLKPYTC
YTLYIRALND IGWSEFSKPS HSLTLPGLPV AHPAVHIINV SSHSISLDVG IATLKDVIQD
NVKRCIDQDA RFISLLHGPL VGYIVTVATT QPYKFASKTL YNASGSYSQI VDISHLKPYT
RYNLSFAFYN GRFSGPFTSL VVSTTEGIPG KPRIKNFESS SNSLSIDWDS NADAVGKILA
YKLELHTCSK NDTQSSKRLK TVQVDSKELQ FVFGNLDHNT CYIIRVASAT KAGFGHFSEI
EVRTKFEAPS PPVAVGAFLL DTNDILINWT CSNESSSILK NPQYLICWHF HSFLSEQKCL
LTQTSSKKEL AYCYCDQQQQ FQWTVIPLSV FKEAKSGRII FTIRSSVSQT NCTDYVNCEI
QSENSNEISL NLSSSTQRYF HTTLKYHLKL DNIAIVGIVS ITLLVFFCVI IGACFANRVH
CFLIMCRETG SCYRKTDIST KYKRIAPFHL SKNTYKAISS KEFRAHVNAC HADDDAGFQA
EFESLEQNVQ TNWSTSVARS SENIAKNRYS NILAYDHSRV ILKETGSKSD YINANYVDGY
HRRAAYIAAQ GPIPSTFDDF WLMVWEQNSN VIVMISNFVE RGRRKCDKYW PSSGHQTYGN
VSVRMISEVV RAFFTIRVFS VRHIKTKRGS KDRLVYHYQY TDWRDFDVPP SPLPVLKFVE
ASVTHWTFDR GPIVVHCSAG VGRTGTYICI ESLIRQLKVE QAVSVRGFLE HIRQQRMKLV
QTEQQYAFIH DALREYILYP YHSIRPLNFS DYLRHLYELD STGTSNLMRQ FEMCMDFRCD
SAGSLHSGTL NVDQTKLPYC SSTTDSSGID SSVLHGFLNV CEYIVTRHPL GNSVTEFWKV
VWDANSSLII CLSDQNLLPF WPDEVEQTRT IGWLHINFAR MDQCSDSLVR FQFLLTSDRE
DYALACTLLH FSAWPSIDLE NPHESRIASD LLELATHLEN DNSEFSNSSA PIVLVDNTGG
YRVGIFCAIR ILISQFLNDL LLDVYFVFKM LCLQRPHLFR GYWDLEFVYT LMQYYLKNES
SPSWQSNSIG SRYATLYYML EGRDNSSKVS TGDQHTSPRR ILGNLFSGRR RLTYPKCQRP
TRNNNDSLLF NETTTISRNN SFRNHSNYNN SFLQHTSQHL CNSISNRTCI FTDPYHQEEP
LLSNHFSNNR GHAVYRLLSK HQSVEFLSFQ SINNHNNNNR KYFTGNQMEY PTL
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