ID   A0A3Q0KRG2_SCHMA        Unreviewed;       912 AA.
AC   A0A3Q0KRG2;
DT   13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT   13-SEP-2023, sequence version 2.
DT   27-MAR-2024, entry version 23.
DE   SubName: Full=Prospero-like protein {ECO:0000313|WBParaSite:Smp_162760.1};
OS   Schistosoma mansoni (Blood fluke).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Trematoda;
OC   Digenea; Strigeidida; Schistosomatoidea; Schistosomatidae; Schistosoma.
OX   NCBI_TaxID=6183 {ECO:0000313|Proteomes:UP000008854, ECO:0000313|WBParaSite:Smp_162760.1};
RN   [1] {ECO:0000313|Proteomes:UP000008854}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Puerto Rican {ECO:0000313|Proteomes:UP000008854};
RX   PubMed=22253936; DOI=10.1371/journal.pntd.0001455;
RA   Protasio A.V., Tsai I.J., Babbage A., Nichol S., Hunt M., Aslett M.A.,
RA   De Silva N., Velarde G.S., Anderson T.J., Clark R.C., Davidson C.,
RA   Dillon G.P., Holroyd N.E., LoVerde P.T., Lloyd C., McQuillan J.,
RA   Oliveira G., Otto T.D., Parker-Manuel S.J., Quail M.A., Wilson R.A.,
RA   Zerlotini A., Dunne D.W., Berriman M.;
RT   "A systematically improved high quality genome and transcriptome of the
RT   human blood fluke Schistosoma mansoni.";
RL   PLoS Negl. Trop. Dis. 6:E1455-E1455(2012).
RN   [2] {ECO:0000313|WBParaSite:Smp_162760.1}
RP   IDENTIFICATION.
RC   STRAIN=Puerto Rican {ECO:0000313|WBParaSite:Smp_162760.1};
RG   WormBaseParasite;
RL   Submitted (DEC-2018) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR   AlphaFoldDB; A0A3Q0KRG2; -.
DR   EnsemblMetazoa; Smp_162760.1; Smp_162760.1; Smp_162760.
DR   WBParaSite; Smp_162760.1; Smp_162760.1; Smp_162760.
DR   InParanoid; A0A3Q0KRG2; -.
DR   Proteomes; UP000008854; Unassembled WGS sequence.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0048468; P:cell development; IEA:UniProt.
DR   GO; GO:0007399; P:nervous system development; IEA:UniProt.
DR   GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR   Gene3D; 1.10.10.500; Homeo-prospero domain; 1.
DR   InterPro; IPR023082; Homeo_prospero_dom.
DR   InterPro; IPR037131; Homeo_prospero_dom_sf.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR039350; Prospero_homeodomain.
DR   PANTHER; PTHR12198:SF0; HOMEOBOX PROTEIN PROSPERO; 1.
DR   PANTHER; PTHR12198; HOMEOBOX PROTEIN PROSPERO/PROX-1/CEH-26; 1.
DR   Pfam; PF05044; HPD; 1.
DR   SUPFAM; SSF46689; Homeodomain-like; 1.
DR   PROSITE; PS51818; HOMEO_PROSPERO; 1.
PE   4: Predicted;
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW   Homeobox {ECO:0000256|ARBA:ARBA00023155};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008854};
KW   Transcription {ECO:0000256|ARBA:ARBA00023163};
KW   Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT   DOMAIN          752..910
FT                   /note="Prospero"
FT                   /evidence="ECO:0000259|PROSITE:PS51818"
FT   REGION          184..209
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          342..361
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          561..586
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          601..622
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        184..199
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   912 AA;  102326 MW;  6293A41027804BF4 CRC64;
     MLTNTTTSTS SSCNPVTAAA AAAALANVLG FPIPYGWSPK ILTDVQDAYG LISNPYYHWP
     WKLLNSPYAP KYSDQNTLLQ SGSLVNNTIN IIERLNKVNP ESTLDSCLKS KFPLNDENKQ
     NNIMMFNDAT SLSTQATSSD EQVEAIPLIV RHDRKVNKSG PVINSNGTIY NSCSSNLTTS
     TNVTTAPITN ESNSFHGPTI SRRRRTKVTD TRLTHSRVSR CPNNAFSNFM MTNSVMQQNN
     RHHHNQPISQ QQSFLQSNSE SIDLGQALNL VTSTSTSFGL SGNQLLADDK ESLLTSQSLL
     PGINPAKYRN SVVSTSTTTG SNINNTSNVK LDDFYSAKYR SENQVHSSGS NNSSPSPISL
     RLSGYSKELT DNTSENRKGH CHENVDISEL DKNNDYQLNG ADEKLHCLNI LQEYKSFEKM
     FTKTLKNYPL SAKSNLLDNI GTLPAVMNIV SSSTPSTYSP SVFKDINTSL EVTTSTSLSI
     SSIFPTSSST TSLPVTSPCS SACSDINQRT LLSRFNQICL LNSRLPNSLP SIPPIFFNPT
     EDTINNNFNH ISNNNTNNTN KFSTGNFYDH TSIQSNGQER QQQSLSHSFE AKNNLSFSHP
     HNLSLSSSLP RKSPSPYSQS LQSSIFSPSQ SLASVIGSID YNTVITTAAN NSIDHNNNNN
     NNNITTISSL QNKHQRLQQN LPNLNSKRHH NHMSYINKLY DKFNANENLR NIKLDKSLLL
     NDNFSGESTS GMTISESYQN QLINYSHELR MTTTLTPVHL RKAKLMFFYT RYPNSTLIKM
     YFPDVKFYKN NTAQLVKWFS NFREFYYIQM EKYARVAISE GIRIADEIHV TIESEIYRAL
     NLHYNRNQQL EVPDHFRIVV EATLREFFNA LYTGKDSEQS WKKPIYKVIA RMDQPVPEFF
     KSPNWMDQLA DG
//