ID A0A3Q0KRM4_SCHMA Unreviewed; 894 AA.
AC A0A3Q0KRM4;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2023, sequence version 2.
DT 27-MAR-2024, entry version 25.
DE RecName: Full=MAGUK p55 subfamily member 5 {ECO:0000256|ARBA:ARBA00032294};
OS Schistosoma mansoni (Blood fluke).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Trematoda;
OC Digenea; Strigeidida; Schistosomatoidea; Schistosomatidae; Schistosoma.
OX NCBI_TaxID=6183 {ECO:0000313|Proteomes:UP000008854, ECO:0000313|WBParaSite:Smp_162790.1};
RN [1] {ECO:0000313|Proteomes:UP000008854}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Puerto Rican {ECO:0000313|Proteomes:UP000008854};
RX PubMed=22253936; DOI=10.1371/journal.pntd.0001455;
RA Protasio A.V., Tsai I.J., Babbage A., Nichol S., Hunt M., Aslett M.A.,
RA De Silva N., Velarde G.S., Anderson T.J., Clark R.C., Davidson C.,
RA Dillon G.P., Holroyd N.E., LoVerde P.T., Lloyd C., McQuillan J.,
RA Oliveira G., Otto T.D., Parker-Manuel S.J., Quail M.A., Wilson R.A.,
RA Zerlotini A., Dunne D.W., Berriman M.;
RT "A systematically improved high quality genome and transcriptome of the
RT human blood fluke Schistosoma mansoni.";
RL PLoS Negl. Trop. Dis. 6:E1455-E1455(2012).
RN [2] {ECO:0000313|WBParaSite:Smp_162790.1}
RP IDENTIFICATION.
RC STRAIN=Puerto Rican {ECO:0000313|WBParaSite:Smp_162790.1};
RG WormBaseParasite;
RL Submitted (DEC-2018) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell projection, axon
CC {ECO:0000256|ARBA:ARBA00004489}. Membrane
CC {ECO:0000256|ARBA:ARBA00004170}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004170}.
CC -!- SIMILARITY: Belongs to the MAGUK family.
CC {ECO:0000256|ARBA:ARBA00007014}.
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DR AlphaFoldDB; A0A3Q0KRM4; -.
DR STRING; 6183.A0A3Q0KRM4; -.
DR EnsemblMetazoa; Smp_162790.1; Smp_162790.1; Smp_162790.
DR WBParaSite; Smp_162790.1; Smp_162790.1; Smp_162790.
DR InParanoid; A0A3Q0KRM4; -.
DR Proteomes; UP000008854; Unassembled WGS sequence.
DR GO; GO:0030424; C:axon; IEA:UniProtKB-SubCell.
DR CDD; cd00992; PDZ_signaling; 1.
DR Gene3D; 2.30.42.10; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR008145; GK/Ca_channel_bsu.
DR InterPro; IPR008144; Guanylate_kin-like_dom.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR23122; MEMBRANE-ASSOCIATED GUANYLATE KINASE MAGUK; 1.
DR PANTHER; PTHR23122:SF14; PROTEIN PALS1; 1.
DR Pfam; PF00625; Guanylate_kin; 1.
DR Pfam; PF00595; PDZ; 1.
DR Pfam; PF07653; SH3_2; 1.
DR SMART; SM00072; GuKc; 1.
DR SMART; SM00228; PDZ; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50156; PDZ domain-like; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS50052; GUANYLATE_KINASE_2; 1.
DR PROSITE; PS50106; PDZ; 1.
DR PROSITE; PS50002; SH3; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000008854};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 286..366
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 375..452
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 694..877
FT /note="Guanylate kinase-like"
FT /evidence="ECO:0000259|PROSITE:PS50052"
FT REGION 469..491
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 509..550
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 509..540
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 894 AA; 102004 MW; E7698FBB73619BD8 CRC64;
MENQKDRNLE FYAEEVRKRQ DLEKEKEGEK EFLRTSLRAS SRLQAIEKYR RIIKKDEYKR
SEVNQAFEDD SKAESSPELT ELLCYLRTKM PVPREEKENK FQSSDVTLPT NETTLDLETE
QWEWLLNVLS DPNLSKAFLM HDKVAKAYET CKSVMHPKPR YRWPVLAGLA YDTMEAVKER
LLTALKNPGQ FDAFTLNCIS AILNLCSSPL FQNLLIAMDG LANTWLFDAD DDFVASESLK
LSDDIDRNSI SSSYIQKSSV PGCYATLAYD DQGRDSYSEH GVRLKYVILQ KTGNEFLGAT
VRLERNSVLI ARIVNGGLAC KTNLLHEGDE LLSVNGIELL GKDLNTVCDI MASLQGRIVL
LVAPALDPYS SVSTKGIIHL RALFTYEPSD DRYIACKELG LGFTKGDIIH VTGRKDPNWW
QAYRSDEERG LSGAIGTLAG LIPSPIYQRN RAILRLKYWL TSGTEDIEFE EDSTDSDSTG
STVIKTEKPT NKSKEKKFLG IKFPTLKNTH FSSRSTSPSG RDTNQTDSKS ELTSVDTSEG
DLTDGVVYTP EDDSRCVMNS TVLSSAYGDR MSGLTKPTDL SSANAINEWS AAGPVWGQHG
YNLRTLCARR KRNRRKLSST NRSSLCLEGL KSWKKDKKHG EYCPFLVPVP DNELQSSDDP
VAWLDKEVAR GYMIHYSLWT YEPVAQYIPQ PLRRRPLVFV GPAHVGRQQI LQHLIQREPD
RFYQAAIYTT NSNLKTDTKF SYICITEEEF RLKRKQKEFI EWGLFNRDYY GTSKLTVRQL
VNEGKICCIS LRPDSLRKIR SSGLDPYVIF ISPPERVDDL QRLRKNLNLA GNCSNDELKA
CIETSRKMEL RFGHWFDRVI IPETLDTTVT ELIRLAIKLE REPTWVPRYW LDLE
//
