ID A0A3Q0KSC9_SCHMA Unreviewed; 585 AA.
AC A0A3Q0KSC9;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=Activating signal cointegrator 1 {ECO:0000313|WBParaSite:Smp_167590.1};
OS Schistosoma mansoni (Blood fluke).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Trematoda;
OC Digenea; Strigeidida; Schistosomatoidea; Schistosomatidae; Schistosoma.
OX NCBI_TaxID=6183 {ECO:0000313|Proteomes:UP000008854, ECO:0000313|WBParaSite:Smp_167590.1};
RN [1] {ECO:0000313|Proteomes:UP000008854}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Puerto Rican {ECO:0000313|Proteomes:UP000008854};
RX PubMed=22253936; DOI=10.1371/journal.pntd.0001455;
RA Protasio A.V., Tsai I.J., Babbage A., Nichol S., Hunt M., Aslett M.A.,
RA De Silva N., Velarde G.S., Anderson T.J., Clark R.C., Davidson C.,
RA Dillon G.P., Holroyd N.E., LoVerde P.T., Lloyd C., McQuillan J.,
RA Oliveira G., Otto T.D., Parker-Manuel S.J., Quail M.A., Wilson R.A.,
RA Zerlotini A., Dunne D.W., Berriman M.;
RT "A systematically improved high quality genome and transcriptome of the
RT human blood fluke Schistosoma mansoni.";
RL PLoS Negl. Trop. Dis. 6:E1455-E1455(2012).
RN [2] {ECO:0000313|WBParaSite:Smp_167590.1}
RP IDENTIFICATION.
RC STRAIN=Puerto Rican {ECO:0000313|WBParaSite:Smp_167590.1};
RG WormBaseParasite;
RL Submitted (DEC-2018) to UniProtKB.
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DR AlphaFoldDB; A0A3Q0KSC9; -.
DR STRING; 6183.A0A3Q0KSC9; -.
DR EnsemblMetazoa; Smp_167590.1; Smp_167590.1; Smp_167590.
DR WBParaSite; Smp_167590.1; Smp_167590.1; Smp_167590.
DR InParanoid; A0A3Q0KSC9; -.
DR OMA; EMHEMKH; -.
DR Proteomes; UP000008854; Unassembled WGS sequence.
DR ExpressionAtlas; A0A3Q0KSC9; baseline.
DR GO; GO:0005634; C:nucleus; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd06554; ASCH_ASC-1_like; 1.
DR Gene3D; 2.30.130.30; Hypothetical protein; 1.
DR InterPro; IPR007374; ASCH_domain.
DR InterPro; IPR015947; PUA-like_sf.
DR InterPro; IPR039128; TRIP4-like.
DR InterPro; IPR009349; Znf_C2HC5.
DR PANTHER; PTHR12963:SF0; EXPRESSED PROTEIN; 1.
DR PANTHER; PTHR12963; THYROID RECEPTOR INTERACTING PROTEIN RELATED; 1.
DR Pfam; PF04266; ASCH; 1.
DR Pfam; PF06221; zf-C2HC5; 1.
DR SUPFAM; SSF88697; PUA domain-like; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000008854}.
FT DOMAIN 136..182
FT /note="Zinc finger C2HC5-type"
FT /evidence="ECO:0000259|Pfam:PF06221"
FT DOMAIN 449..537
FT /note="ASCH"
FT /evidence="ECO:0000259|Pfam:PF04266"
FT REGION 217..244
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 222..238
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 585 AA; 66215 MW; BCDE6685E474F7BC CRC64;
MEKVKSILTK TLGEKAAMDF IKACMEVDDT QIIKRRVSTL LDTRKMENRQ VYEILIREKI
RRSGFSGEGY RKSNCIAGVL NNTLTPPDKI SDSEKVDVEQ LSSQTAKKGR QKTKFYPLFC
EGAQGDQLVS LLPGRHPCQC LATKHQLVNN CLNCGRIVCA QEGSGPCYYC GNLVCTIDEE
YQLSQGIAKH SQKLRNKLSQ AAWAPGTETP YYRRIRRAQK SKQESSGGII SVDSNSNDGL
ESDTDDNDLI KTSAQGAQIR LEQGLINALC KRDKLLEFDT TCARRTRVID DELDYFATEG
GVGSAAWLSP EVRERIARRV IELRAQRHTH RFQSARMCID LDKCDVIKED TRDEAAVKLY
NPSQEEMDEL RESPTISNVN QSFRDSQKTV NSNISEITLP TFIPQSMDSK NYTANNDQNP
VVMALNQSTS LLRIQDDESR QLVDEGYCLS LHQPWASLLV RGIKLEEGRT WYTPYRGCLW
IASTAHKTDP EEITEIENKY LKAGVPKSDM PTSYPTSCLL GRVNIVDVIT QEEYREKQPD
GLSQSSYVFI CADPRETLIK FPIRGKHKIY KLEKHMHIAA KKNLT
//
