ID A0A3Q0KSK2_SCHMA Unreviewed; 608 AA.
AC A0A3Q0KSK2;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE RecName: Full=Protein Wnt {ECO:0000256|RuleBase:RU003500};
OS Schistosoma mansoni (Blood fluke).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Trematoda;
OC Digenea; Strigeidida; Schistosomatoidea; Schistosomatidae; Schistosoma.
OX NCBI_TaxID=6183 {ECO:0000313|Proteomes:UP000008854, ECO:0000313|WBParaSite:Smp_167140.1};
RN [1] {ECO:0000313|Proteomes:UP000008854}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Puerto Rican {ECO:0000313|Proteomes:UP000008854};
RX PubMed=22253936; DOI=10.1371/journal.pntd.0001455;
RA Protasio A.V., Tsai I.J., Babbage A., Nichol S., Hunt M., Aslett M.A.,
RA De Silva N., Velarde G.S., Anderson T.J., Clark R.C., Davidson C.,
RA Dillon G.P., Holroyd N.E., LoVerde P.T., Lloyd C., McQuillan J.,
RA Oliveira G., Otto T.D., Parker-Manuel S.J., Quail M.A., Wilson R.A.,
RA Zerlotini A., Dunne D.W., Berriman M.;
RT "A systematically improved high quality genome and transcriptome of the
RT human blood fluke Schistosoma mansoni.";
RL PLoS Negl. Trop. Dis. 6:E1455-E1455(2012).
RN [2] {ECO:0000313|WBParaSite:Smp_167140.1}
RP IDENTIFICATION.
RC STRAIN=Puerto Rican {ECO:0000313|WBParaSite:Smp_167140.1};
RG WormBaseParasite;
RL Submitted (DEC-2018) to UniProtKB.
CC -!- FUNCTION: Ligand for members of the frizzled family of seven
CC transmembrane receptors. {ECO:0000256|RuleBase:RU003500}.
CC -!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular
CC matrix {ECO:0000256|ARBA:ARBA00004498, ECO:0000256|RuleBase:RU003500}.
CC -!- SIMILARITY: Belongs to the Wnt family. {ECO:0000256|ARBA:ARBA00005683,
CC ECO:0000256|RuleBase:RU003500}.
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DR AlphaFoldDB; A0A3Q0KSK2; -.
DR STRING; 6183.A0A3Q0KSK2; -.
DR EnsemblMetazoa; Smp_167140.1; Smp_167140.1; Smp_167140.
DR WBParaSite; Smp_167140.1; Smp_167140.1; Smp_167140.
DR InParanoid; A0A3Q0KSK2; -.
DR Proteomes; UP000008854; Unassembled WGS sequence.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR GO; GO:0005102; F:signaling receptor binding; IEA:InterPro.
DR GO; GO:0016055; P:Wnt signaling pathway; IEA:UniProtKB-KW.
DR CDD; cd13113; Wnt; 1.
DR Gene3D; 3.30.2460.20; -; 1.
DR InterPro; IPR005817; Wnt.
DR InterPro; IPR043158; Wnt_C.
DR InterPro; IPR018161; Wnt_CS.
DR PANTHER; PTHR12027:SF37; PROTEIN WNT; 1.
DR PANTHER; PTHR12027; WNT RELATED; 1.
DR Pfam; PF00110; wnt; 2.
DR PRINTS; PR01349; WNTPROTEIN.
DR SMART; SM00097; WNT1; 1.
DR PROSITE; PS00246; WNT1; 1.
PE 3: Inferred from homology;
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473,
KW ECO:0000256|RuleBase:RU003500};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Extracellular matrix {ECO:0000256|ARBA:ARBA00022530};
KW Reference proteome {ECO:0000313|Proteomes:UP000008854};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Wnt signaling pathway {ECO:0000256|ARBA:ARBA00022687,
KW ECO:0000256|RuleBase:RU003500}.
SQ SEQUENCE 608 AA; 70202 MW; 9D98C9D3BA85A5A9 CRC64;
MIHSILIYIG LNLIYPFSIK ISICSMNSGN WVFDLLMLSH LKKLNSPLYM PVKHINHITN
PFEHHHLMNP SNVLNSSGRK LIRASTSSES QDHLLSNQNE LNQLDNHSQV PIQSFPSNDI
DLSNHEISIC HTLSGLTNRQ RYICLQHTGL IWAMLEGTHL GMHECVHQFK HEQWNCSAVN
LLYRTHIKSS SLSLTHGLEG ILQRGSRETA FLSSSWSAGV VQAITRACSR GQMGTCDCDP
HRREGQGRDA EGIFTWGGCS DPIRFGMRLA RLFLDANDEE HRNAAVQREQ ELHEQRIQLL
SSMRLSSQDK RNPREPQRMY RFPRSFNNST SDQHFKPNGI ENVKNIVKPV NKTKPILSAR
ELQRETLQII QTKARTLMNL HNKKAGRRLI WKNRITKCKC HGVSGACSMR TCWQRVNEFR
LIGMMLKAAY DSAIHVTYEP RIDQLKRISN RINSNQNNNY MTRRNLPVVS PNRNHDSRNW
LVLIKSHSNN SSKDDWNDYS NNGRLQRRWP RTVMTKSKEI PKNQLVYLEE SPNYCFFDET
IGHLGIAGRQ CNATSKDAIN SCSRLCCDSG YDTLELEREQ KCECKFFWCC EVRCNICRDK
TTLHHCKH
//
