ID A0A3Q0KTH2_SCHMA Unreviewed; 621 AA.
AC A0A3Q0KTH2;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=Homeobox protein aristaless-related {ECO:0000313|WBParaSite:Smp_175710.1};
OS Schistosoma mansoni (Blood fluke).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Trematoda;
OC Digenea; Strigeidida; Schistosomatoidea; Schistosomatidae; Schistosoma.
OX NCBI_TaxID=6183 {ECO:0000313|Proteomes:UP000008854, ECO:0000313|WBParaSite:Smp_175710.1};
RN [1] {ECO:0000313|Proteomes:UP000008854}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Puerto Rican {ECO:0000313|Proteomes:UP000008854};
RX PubMed=22253936; DOI=10.1371/journal.pntd.0001455;
RA Protasio A.V., Tsai I.J., Babbage A., Nichol S., Hunt M., Aslett M.A.,
RA De Silva N., Velarde G.S., Anderson T.J., Clark R.C., Davidson C.,
RA Dillon G.P., Holroyd N.E., LoVerde P.T., Lloyd C., McQuillan J.,
RA Oliveira G., Otto T.D., Parker-Manuel S.J., Quail M.A., Wilson R.A.,
RA Zerlotini A., Dunne D.W., Berriman M.;
RT "A systematically improved high quality genome and transcriptome of the
RT human blood fluke Schistosoma mansoni.";
RL PLoS Negl. Trop. Dis. 6:E1455-E1455(2012).
RN [2] {ECO:0000313|WBParaSite:Smp_175710.1}
RP IDENTIFICATION.
RC STRAIN=Puerto Rican {ECO:0000313|WBParaSite:Smp_175710.1};
RG WormBaseParasite;
RL Submitted (DEC-2018) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|PROSITE-ProRule:PRU00108,
CC ECO:0000256|RuleBase:RU000682}.
CC -!- SIMILARITY: Belongs to the paired homeobox family. Unc-4 subfamily.
CC {ECO:0000256|ARBA:ARBA00038351}.
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DR AlphaFoldDB; A0A3Q0KTH2; -.
DR STRING; 6183.A0A3Q0KTH2; -.
DR EnsemblMetazoa; Smp_175710.1; Smp_175710.1; Smp_175710.
DR WBParaSite; Smp_175710.1; Smp_175710.1; Smp_175710.
DR InParanoid; A0A3Q0KTH2; -.
DR Proteomes; UP000008854; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR CDD; cd00086; homeodomain; 1.
DR Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR000047; HTH_motif.
DR PANTHER; PTHR46799; HOMEOBOX PROTEIN UNC-4 HOMOLOG; 1.
DR PANTHER; PTHR46799:SF1; HOMEOBOX PROTEIN UNC-4 HOMOLOG; 1.
DR Pfam; PF00046; Homeodomain; 1.
DR PRINTS; PR00031; HTHREPRESSR.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; Homeodomain-like; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 3: Inferred from homology;
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW Differentiation {ECO:0000256|ARBA:ARBA00022782};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW ProRule:PRU00108};
KW Homeobox {ECO:0000256|ARBA:ARBA00023155, ECO:0000256|PROSITE-
KW ProRule:PRU00108};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE-
KW ProRule:PRU00108}; Reference proteome {ECO:0000313|Proteomes:UP000008854};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 320..380
FT /note="Homeobox"
FT /evidence="ECO:0000259|PROSITE:PS50071"
FT DNA_BIND 322..381
FT /note="Homeobox"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00108"
FT REGION 195..221
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 274..327
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 429..462
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 287..313
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 435..462
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 621 AA; 71862 MW; 042588657801F032 CRC64;
MNNTFSENNV LNSDSMTICL NTYLDNNNYQ KLITSEQLNK FTLLNHSSLE NNSIINRHIF
DKAYEQKTSD SIDLKNVMKT FQEQYFNQFT NNNNWILSVI NEMKNNSVNH KLETCQNILN
HISLEQVQTD KQGNICLSDH LKLNSQKSLT NICNNTKDLS TNFVTNLCTK LNSRSIKHKN
KTKDVLYKFN KMTSDKRVKQ KEEEEEEEGG EEEAEKQSCQ TSLLNNELQH SEHYNYQVNN
SNNNIESNGY VEGNNIVSDQ LCNEKTNVSI SGTKSNAGIY VNDTDDSDNQ YDNDDEMEDT
DDDDEEEEDE NDSNENDNNK RRRRTRTNFS GQQLTELELV FRVSHYPSMI VREELAQRLG
LPESRIQVWF QNRRAKWRKR EHTRKGPGRP AHNAQLLTCS GEPIDPNELL KREASRLEAR
RRKMVEKRIQ SLKKKQTVIR QNHTSKLVSS RTTQKNPKSL NFQHNDCENS VLNDKLPLNL
TPSTKHIEEF RQNLLFPNIT TSENSLNLST EFQSLCKQSN IRFNNSIAVH PHSIWSNVQS
NQSTDVNLWN SQLHTDNSIT NHCVNFSRQS FSQQNVDKVH KTQNNTLKSC FNNNNNINLS
KSTDSPFSIE CILSSTSSLS H
//
