ID   A0A3Q0KU90_SCHMA        Unreviewed;      1258 AA.
AC   A0A3Q0KU90;
DT   13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT   13-FEB-2019, sequence version 1.
DT   27-MAR-2024, entry version 20.
DE   SubName: Full=Putative histone deacetylase 4, 5 {ECO:0000313|WBParaSite:Smp_191310.1};
OS   Schistosoma mansoni (Blood fluke).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Trematoda;
OC   Digenea; Strigeidida; Schistosomatoidea; Schistosomatidae; Schistosoma.
OX   NCBI_TaxID=6183 {ECO:0000313|Proteomes:UP000008854, ECO:0000313|WBParaSite:Smp_191310.1};
RN   [1] {ECO:0000313|Proteomes:UP000008854}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Puerto Rican {ECO:0000313|Proteomes:UP000008854};
RX   PubMed=22253936; DOI=10.1371/journal.pntd.0001455;
RA   Protasio A.V., Tsai I.J., Babbage A., Nichol S., Hunt M., Aslett M.A.,
RA   De Silva N., Velarde G.S., Anderson T.J., Clark R.C., Davidson C.,
RA   Dillon G.P., Holroyd N.E., LoVerde P.T., Lloyd C., McQuillan J.,
RA   Oliveira G., Otto T.D., Parker-Manuel S.J., Quail M.A., Wilson R.A.,
RA   Zerlotini A., Dunne D.W., Berriman M.;
RT   "A systematically improved high quality genome and transcriptome of the
RT   human blood fluke Schistosoma mansoni.";
RL   PLoS Negl. Trop. Dis. 6:E1455-E1455(2012).
RN   [2] {ECO:0000313|WBParaSite:Smp_191310.1}
RP   IDENTIFICATION.
RC   STRAIN=Puerto Rican {ECO:0000313|WBParaSite:Smp_191310.1};
RG   WormBaseParasite;
RL   Submitted (DEC-2018) to UniProtKB.
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DR   AlphaFoldDB; A0A3Q0KU90; -.
DR   STRING; 6183.A0A3Q0KU90; -.
DR   EnsemblMetazoa; Smp_191310.1; Smp_191310.1; Smp_191310.
DR   WBParaSite; Smp_191310.1; Smp_191310.1; Smp_191310.
DR   InParanoid; A0A3Q0KU90; -.
DR   Proteomes; UP000008854; Unassembled WGS sequence.
DR   GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR   CDD; cd11681; HDAC_classIIa; 1.
DR   Gene3D; 3.40.800.20; Histone deacetylase domain; 1.
DR   InterPro; IPR000286; His_deacetylse.
DR   InterPro; IPR023801; His_deacetylse_dom.
DR   InterPro; IPR037138; His_deacetylse_dom_sf.
DR   InterPro; IPR023696; Ureohydrolase_dom_sf.
DR   PANTHER; PTHR10625:SF15; HISTONE DEACETYLASE; 1.
DR   PANTHER; PTHR10625; HISTONE DEACETYLASE HDAC1-RELATED; 1.
DR   Pfam; PF00850; Hist_deacetyl; 2.
DR   PRINTS; PR01270; HDASUPER.
DR   SUPFAM; SSF52768; Arginase/deacetylase; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000008854}.
FT   DOMAIN          706..855
FT                   /note="Histone deacetylase"
FT                   /evidence="ECO:0000259|Pfam:PF00850"
FT   DOMAIN          894..1054
FT                   /note="Histone deacetylase"
FT                   /evidence="ECO:0000259|Pfam:PF00850"
FT   REGION          53..73
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          91..118
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          630..650
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1201..1226
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1258 AA;  138559 MW;  652AABB61D9D9F70 CRC64;
     MYTDINISNQ SNNTNLTSLL VRERLKNCVL NKRKSKEQSI HINNTTVLNM GITPQQQQQQ
     QQQQQQQQAN HVTDKDLTQI NQEQSISNSS LINNKLNGGK SIPLSNQNGN NNSSTNDGNC
     ITPLMIDVEN LSSQHHHQTN PITSLSNNTK KSNTLHQIQH SLSNHETDIH YMDFQNVHTS
     DIETSIYGNH LIEHNHSSHH HHHYHQQQQQ NKCIDENLRK TVSEPSLKMR SGSGGVQKSR
     YKPDRRHYNQ HHHHHFGMNT ATAAAAVAAA AITVSNDPLA IVGLWPQLSS AFQHANLIQK
     TINKKPLQQL QDMNNNNNNN NMSSIDSDER LSKSEVKSLT QSMTPLSKTF QDVILTELMK
     RNQLIETINT CCSGSQPMDS SISFGDPNIN QSIFNSTING FCASLPNLTA QYHRTAASTS
     SSSSTSQTNH NININRTTST TMHTNTSTPT IHHVTESSFD SNEFNQPDAT MSDLINITNN
     PNESNTEFNQ TKQISKPFHL FPYRRHQSIG LISRTRSAPL SLATGYSTNY RHIQLQNLNN
     VHNLSNSMNT PTSVTSAANI LAMEAATTNF GNQQQTNGLN SNQSMIENDQ LGVQSNNLQS
     SVDNELSSRS KVVLQLRKKI LERSEFLTSD RSGVNNLDGS NSPNSRINQT TGRINPLLER
     TASSPVVNMA PTIRSETVPE ATFTTVLAYD LGMLAHHCTC QTDANHPENP QRLISIWQRL
     QQTGLAAKCH HQPGRRASLI ELQLVHKDVY TVLFGSNPAS RCRIDPTLLA TVRLCRLACG
     GVGVDSDTAW HTAGHTAHAA RLAAGCVVDL ACRVMLGQCP NGFALVRPPG HHAEPGQAMG
     FCYFNSVAIA AKRAQFLGST TLGTGQSSVI SSSATTLFDQ STFLPYTIES ALKPRILIVD
     WDIHHGNGTQ TVFYTDPTVL YISLHRHDEG GFFPGTGSPE EIGSGPGEGY TINIAWPSGI
     VMSDAEYLAA FRLIILPVAC EFQPSIVLIS AGFDAAPGHS ANLGGYSVSP AAFGWMTRLL
     SIDRIANSKV VLSLEGGYDM NSLCDCTEAC VRALLRSAAE INERNSIPIS VPDLIPLKQS
     ELDRVPHPSA IQTLLKVAHL HSVYWTSFSN EIDTQYASMP ASSWLPTIFD NSSIEIKDLS
     STTEHISVVS TNVTPLSANK RFLKSLIKQT PLTTDLNVLT SGNVTENNRY YNFVMRQASS
     MDETNETEMK PNSIRRRSTT GITPSNMDSI TSINDTNETI TRIALTRLAE LHVTSQPE
//